RNF25

RNF25
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DAY, 2DMF, 5D1M, 5D1L, 5D1K
Identifiers
Aliases	RNF25 , AO7, ring finger protein 25
External IDs	OMIM: 616014; MGI: 1890215; HomoloGene: 11193; GeneCards: RNF25; OMA:RNF25 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q35 Start 218,663,892 bp [1] End 218,672,002 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C4 Start 74,632,907 bp [2] End 74,640,556 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary granulocyte popliteal artery tibial arteries prefrontal cortex Descending thoracic aorta left testis right testis stromal cell of endometrium right frontal lobe Top expressed in neural layer of retina granulocyte spermatid superior frontal gyrus yolk sac seminiferous tubule cerebellar cortex dentate gyrus of hippocampal formation granule cell ventricular zone primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding ubiquitin protein ligase activity NF-kappaB binding ubiquitin-protein transferase activity transferase activity protein binding Cellular component cytosol nucleus Biological process positive regulation of NF-kappaB transcription factor activity protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64320 57751 Ensembl ENSG00000163481 ENSMUSG00000026171 UniProt Q96BH1 Q9QZR0 RefSeq (mRNA) NM_022453 NM_021313 NM_001305230 RefSeq (protein) NP_071898 NP_001292159 NP_067288 Location (UCSC) Chr 2: 218.66 – 218.67 Mb Chr 1: 74.63 – 74.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RNF25 is an enzyme that in humans is encoded by the RNF25 gene. ^{[5] [6]}

Function

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NF-κB), and modulate NF-κB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. ^[6]

Interactions

RNF25 has been shown to interact with RELA. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000163481 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026171 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (Jul 2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J. Biol. Chem. 278 (29): 26879–87. doi: 10.1074/jbc.M211831200 . PMID   12748188.
6. "Entrez Gene: RNF25 ring finger protein 25".

Further reading

• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. Bibcode:1999PNAS...9611364L. doi: 10.1073/pnas.96.20.11364 . PMC   18039 . PMID   10500182.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.