RPA4

RPA4
Identifiers
Aliases	RPA4 , HSU24186, replication protein A4
External IDs	OMIM: 300767 HomoloGene: 88820 GeneCards: RPA4
Gene location (Human)
Chr.	X chromosome (human)
End	96,885,467 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; visceral pleura; ; parietal pleura; ; bone marrow; ; Achilles tendon; ; monocyte; ; placenta; ; Stromal cell of endometrium; ; right coronary artery; ; liver;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	single-stranded DNA binding ; DNA binding ; damaged DNA binding ; double-stranded DNA binding ; protein binding ; sequence-specific DNA binding ; G-rich strand telomeric DNA binding ;
Cellular component	DNA replication factor A complex ; nucleus ; nucleoplasm ; chromosome, telomeric region ; chromatin ; condensed nuclear chromosome ; site of double-strand break ;
Biological process	nucleotide-excision repair ; DNA damage checkpoint signaling ; DNA replication ; DNA recombination ; DNA replication initiation ; nuclear DNA replication ; DNA repair ; cellular response to DNA damage stimulus ; G1/S transition of mitotic cell cycle ; telomere maintenance via recombination ; double-strand break repair via homologous recombination ; DNA topological change ; DNA unwinding involved in DNA replication ; base-excision repair ; DNA mismatch repair ; mitotic recombination ; telomere maintenance via telomerase ; reciprocal meiotic recombination ; heteroduplex formation ; positive regulation of helicase activity ; regulation of DNA damage checkpoint ;
	Sources:Amigo / QuickGO
Orthologs
	29935
	n/a
	ENSG00000204086
	n/a
	Q13156
	n/a
	NM_013347
	n/a
	NP_037479
	n/a
	Wikidata
View/Edit Human

Last updated September 05, 2022

Replication protein A 30 kDa subunit is a protein that in humans is encoded by the RPA4 gene.^[3]^[4]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000204086 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Keshav KF, Chen C, Dutta A (Jun 1995). "Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex". Mol Cell Biol. 15 (6): 3119–28. doi:10.1128/mcb.15.6.3119. PMC 230543 . PMID 7760808.
↑ "Entrez Gene: RPA4 replication protein A4, 34kDa".

Wu X, Yang Z, Liu Y, Zou Y (2006). "Preferential localization of hyperphosphorylated replication protein A to double-strand break repair and checkpoint complexes upon DNA damage". Biochem. J. 391 (Pt 3): 473–80. doi:10.1042/BJ20050379. PMC 1276948 . PMID 15929725.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286 . PMID 15772651.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Parker A, Gu Y, Mahoney W, et al. (2001). "Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair". J. Biol. Chem. 276 (8): 5547–55. doi: 10.1074/jbc.M008463200 . PMID 11092888.
Amacker M, Hottiger M, Mossi R, Hübscher U (1997). "HIV-1 nucleocapsid protein and replication protein A influence the strand displacement DNA synthesis of lentiviral reverse transcriptase". AIDS. 11 (4): 534–6. PMID 9084803.
Li L, Lu X, Peterson CA, Legerski RJ (1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair". Mol. Cell. Biol. 15 (10): 5396–402. doi:10.1128/mcb.15.10.5396. PMC 230789 . PMID 7565690.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000204086 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7760808-3] Keshav KF, Chen C, Dutta A (Jun 1995). "Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex". Mol Cell Biol. 15 (6): 3119–28. doi:10.1128/mcb.15.6.3119. PMC 230543 . PMID 7760808.

[entrez-4] "Entrez Gene: RPA4 replication protein A4, 34kDa".

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RPA4

Related Research Articles

References

Further reading