RPP14

RPP14
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IR3
Identifiers
Aliases	RPP14 , P14, HsHTD2, ribonuclease P/MRP subunit p14
External IDs	OMIM: 606112 MGI: 1914303 HomoloGene: 5113 GeneCards: RPP14
Gene location (Human)
Chr.	Chromosome 3 (human)
End	58,324,695 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	14,389,406 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; Achilles tendon; ; stromal cell of endometrium; ; smooth muscle tissue; ; left ventricle; ; rectum; ; islet of Langerhans; ; ganglionic eminence; ; right lobe of liver; ; monocyte;
	Top expressed in
	seminal vesicula; ; sternocleidomastoid muscle; ; morula; ; temporal muscle; ; triceps brachii muscle; ; facial motor nucleus; ; digastric muscle; ; saccule; ; otic placode; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ribonuclease activity ; hydrolase activity ; RNA binding ; ribonuclease P activity ; lyase activity ; 3-hydroxyacyl-CoA dehydratase activity ;
Cellular component	nucleus ; nucleoplasm ; multimeric ribonuclease P complex ; nucleolus ; mitochondrion ; mitochondrial matrix ;
Biological process	RNA phosphodiester bond hydrolysis ; RNA phosphodiester bond hydrolysis, endonucleolytic ; tRNA processing ; tRNA 5'-leader removal ; fatty acid metabolic process ; lipid metabolism ; fatty-acyl-CoA biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	11102
	67053
	ENSG00000163684
	ENSMUSG00000023156
	O95059 ; P86397
	Q9CQH8
	NM_001098783 ; NM_007042
	NM_025938
NP_001092253 ; NP_008973 ; NP_001335641 ; NP_001335642 ; NP_001335643 ;
	NP_001335644
	NP_080214
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 19, 2023

Ribonuclease P protein subunit p14 is an enzyme that in humans is encoded by the RPP14 gene.^[5]^[6]^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163684 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023156 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jarrous N, Eder PS, Wesolowski D, Altman S (Mar 1999). "Rpp14 and Rpp29, two protein subunits of human ribonuclease P". RNA. 5 (2): 153–157. doi:10.1017/S135583829800185X. PMC 1369747 . PMID 10024167.
↑ Jiang T, Altman S (Apr 2002). "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity". Proc Natl Acad Sci U S A. 99 (8): 5295–5300. doi: 10.1073/pnas.072083699 . PMC 122763 . PMID 11929972.
↑ "Entrez Gene: RPP14 ribonuclease P 14kDa subunit".

Jiang T, Altman S (2001). "Protein-protein interactions with subunits of human nuclear RNase P". Proc. Natl. Acad. Sci. U.S.A. 98 (3): 920–925. doi: 10.1073/pnas.021561498 . PMC 14685 . PMID 11158571.
Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome". Science. 291 (5507): 1304–1351. Bibcode:2001Sci...291.1304V. doi:10.1126/science.1058040. PMID 11181995.
Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P". RNA. 7 (7): 937–941. doi:10.1017/S1355838201010299. PMC 1370153 . PMID 11455963.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID 14702039.
Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–2146. doi:10.1093/nar/gkh539. PMC 407822 . PMID 15096576.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316 . PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163684 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023156 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10024167-5] Jarrous N, Eder PS, Wesolowski D, Altman S (Mar 1999). "Rpp14 and Rpp29, two protein subunits of human ribonuclease P". RNA. 5 (2): 153–157. doi:10.1017/S135583829800185X. PMC 1369747 . PMID 10024167.

[pmid11929972-6] Jiang T, Altman S (Apr 2002). "A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3'-->5' exoribonuclease activity". Proc Natl Acad Sci U S A. 99 (8): 5295–5300. doi: 10.1073/pnas.072083699 . PMC 122763 . PMID 11929972.

[entrez-7] "Entrez Gene: RPP14 ribonuclease P 14kDa subunit".

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RPP14

Related Research Articles

References

Further reading