RPP30

RPP30
Identifiers
Aliases	RPP30 , TSG15, ribonuclease P/MRP subunit p30
External IDs	OMIM: 606115 MGI: 1859683 HomoloGene: 38180 GeneCards: RPP30
Gene location (Human)
Chr.	Chromosome 10 (human)
End	90,908,553 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	36,082,177 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; islet of Langerhans; ; gastric mucosa; ; gastrocnemius muscle; ; tibial nerve; ; thoracic diaphragm; ; rectum; ; monocyte; ; left coronary artery;
	Top expressed in
	spermatocyte; ; spermatid; ; medial ganglionic eminence; ; morula; ; otic placode; ; primitive streak; ; facial motor nucleus; ; yolk sac; ; somite; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ribonuclease activity ; protein binding ; catalytic activity ; hydrolase activity ; RNA binding ; ribonuclease P activity ;
Cellular component	nucleolus ; nucleus ; nucleolar ribonuclease P complex ; nucleoplasm ; ribonuclease MRP complex ; multimeric ribonuclease P complex ;
Biological process	rRNA processing ; tRNA processing ; RNA phosphodiester bond hydrolysis, endonucleolytic ; tRNA 5'-leader removal ; RNA phosphodiester bond hydrolysis ;
	Sources:Amigo / QuickGO
Orthologs
	10556
	54364
	ENSG00000148688
	ENSMUSG00000024800
	P78346
	O88796
	NM_001104546 ; NM_006413
	NM_019428
	NP_001098016 ; NP_006404
	NP_062301
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Ribonuclease P protein subunit p30 is an enzyme that in humans is encoded by the RPP30 gene.^[5]^[6]^[7]

Related Research Articles

Ribonuclease P is a type of ribonuclease which cleaves RNA. RNase P is unique from other RNases in that it is a ribozyme – a ribonucleic acid that acts as a catalyst in the same way that a protein-based enzyme would. Its function is to cleave off an extra, or precursor, sequence of RNA on tRNA molecules. Further, RNase P is one of two known multiple turnover ribozymes in nature, the discovery of which earned Sidney Altman and Thomas Cech the Nobel Prize in Chemistry in 1989: in the 1970s, Altman discovered the existence of precursor tRNA with flanking sequences and was the first to characterize RNase P and its activity in processing of the 5' leader sequence of precursor tRNA. Recent findings also reveal that RNase P has a new function. It has been shown that human nuclear RNase P is required for the normal and efficient transcription of various small noncoding RNAs, such as tRNA, 5S rRNA, SRP RNA and U6 snRNA genes, which are transcribed by RNA polymerase III, one of three major nuclear RNA polymerases in human cells.

Eosinophil-derived neurotoxin is an enzyme that in humans is encoded by the RNASE2 gene.

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.

Ribonuclease P protein subunit p20 is an enzyme that in humans is encoded by the POP7 gene.

Ribonuclease P protein subunit p40 is an enzyme that in humans is encoded by the RPP40 gene.

Ribonucleases P/MRP protein subunit POP1 is a protein that in humans is encoded by the POP1 gene.

Exosome component 8, also known as EXOSC8, is a human gene, the protein product of which is part of the exosome complex.

Ribonuclease P/MRP protein subunit POP5 is an enzyme that in humans is encoded by the POP5 gene.

Ribonuclease P protein subunit p38 is an enzyme that in humans is encoded by the RPP38 gene.

Ribonuclease P protein subunit p14 is an enzyme that in humans is encoded by the RPP14 gene.

28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.

28S ribosomal protein S7, mitochondrial is a protein that in humans is encoded by the MRPS7 gene.

39S ribosomal protein L11, mitochondrial is a protein that in humans is encoded by the MRPL11 gene.

39S ribosomal protein L19, mitochondrial is a protein that in humans is encoded by the MRPL19 gene.

39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene.

39S ribosomal protein L24, mitochondrial is a protein that in humans is encoded by the MRPL24 gene.

Ribonuclease P protein subunit p29 is an enzyme that in humans is encoded by the POP4 gene.

39S ribosomal protein L17, mitochondrial is a protein that in humans is encoded by the MRPL17 gene.

Ribonuclease H1 also known as RNase H1 is an enzyme that in humans is encoded by the RNASEH1 gene. The RNase H1 is a non-specific endonuclease and catalyzes the cleavage of RNA via a hydrolytic mechanism.

Ribonuclease H2 subunit A, also known as RNase H2 subunit A, is an enzyme that in humans is encoded by the RNASEH2A gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000148688 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024800 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Eder PS, Kekuda R, Stolc V, Altman S (Mar 1997). "Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P". Proc Natl Acad Sci U S A. 94 (4): 1101–6. Bibcode:1997PNAS...94.1101E. doi: 10.1073/pnas.94.4.1101 . PMC 19751 . PMID 9037013.
↑ Stolc V, Altman S (Oct 1997). "Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae". Genes Dev. 11 (18): 2414–25. doi:10.1101/gad.11.18.2414. PMC 316520 . PMID 9308968.
↑ "Entrez Gene: RPP30 ribonuclease P/MRP 30kDa subunit".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Jarrous N, Eder PS, Guerrier-Takada C, et al. (1998). "Autoantigenic properties of some protein subunits of catalytically active complexes of human ribonuclease P". RNA. 4 (4): 407–17. PMC 1369627 . PMID 9630247.
Jiang T, Guerrier-Takada C, Altman S (2001). "Protein-RNA interactions in the subunits of human nuclear RNase P". RNA. 7 (7): 937–41. doi:10.1017/S1355838201010299. PMC 1370153 . PMID 11455963.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC 407822 . PMID 15096576.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Wimplinger I, Morleo M, Rosenberger G, et al. (2006). "Mutations of the Mitochondrial Holocytochrome c–Type Synthase in X-Linked Dominant Microphthalmia with Linear Skin Defects Syndrome". Am. J. Hum. Genet. 79 (5): 878–89. doi:10.1086/508474. PMC 1698567 . PMID 17033964.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000148688 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024800 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9037013-5] Eder PS, Kekuda R, Stolc V, Altman S (Mar 1997). "Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P". Proc Natl Acad Sci U S A. 94 (4): 1101–6. Bibcode:1997PNAS...94.1101E. doi: 10.1073/pnas.94.4.1101 . PMC 19751 . PMID 9037013.

[pmid9308968-6] Stolc V, Altman S (Oct 1997). "Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae". Genes Dev. 11 (18): 2414–25. doi:10.1101/gad.11.18.2414. PMC 316520 . PMID 9308968.

[entrez-7] "Entrez Gene: RPP30 ribonuclease P/MRP 30kDa subunit".

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RPP30

Related Research Articles

References

Further reading