Ravi Bhushan

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Ravi Bhushan
Ravi Bhushan (2022).jpg
Ravi Bhushan
Born(1953-04-12)12 April 1953
EducationBSc at University of Jodhpur
MSc at University of Jodhpur
PhD at University of Jodhpur
Alma materUniversity of Jodhpur
Known for
Scientific career
Institutions Indian Institute of Technology Roorkee
Thesis  (1978)
Doctoral advisor Ramesh Chandra Kapoor

Ravi Bhushan (born 12 April 1953, in Muzaffarnagar, India) was a Professor of Chemistry at Indian Institute of Technology Roorkee who worked in the areas of natural products chemistry, protein chemistry, and chiral analysis by liquid chromatography.

Contents

Education and academic career

Bhushan began his education in his native India, completing his undergraduate degree and his master's from the University of Jodhpur. He received his Ph.D. in chemistry (working on structure elucidation of natural products isolated from certain desert plants) in 1978 at the University of Jodhpur. Bhushan joined as lecturer at the University of Roorkee (now Indian Institute of Technology Roorkee, India) in 1979 and was later selected for the position of full professor of chemistry in 1996 and served there till retirement in 2018.[ citation needed ]

Research

He started his research in the chemistry of natural products. At Washington State University he established early steps in metabolism of d-neomethyl-α-D-glucoside in pipermint (Mentha piperita) rhizomes via in vivo studies. Bhushan developed a de novo method for direct resolution of certain racemates by liquid chromatography. Later, the approach was applied for direct enantioseparation of several active pharmaceutical ingredients (APIs). It is now an established approach in literature. 1994 onwards, the method was extended to such resolutions by ligand exchange principle. [1] The method is of significant importance to pharmaceutical industry and analytical laboratories associated with regulatory agencies for determination and control of enantiomeric purity (and isolation of native enantiomers) of a variety of APIs since many of them are marketed and administered as racemic mixture while only one enantiomer is therapeutically useful. [2]

Bhushan supervised the Ph.D. theses of > 30 scholars and has published more than 270 research papers.

Editorial work

Bhushan is a member of editorial board of

Honours and awards

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References

  1. Ravi Bhushan, Jürgen Martens. Amino Acids: Chromatographic Separation and Enantioresolution, HNB Publishing, New York, 2010, S. 322, ISBN 978-0-9728061-3-8.
  2. Everhardus Jacobus Ariëns (1984). "Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology". Eur. J. Clin. Pharmacol. 26 (6): 663–668. doi:10.1007/BF00541922. PMID   6092093. S2CID   30916093.