Richard Passingham | |
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Born | Richard Edward Passingham 6 August 1943 |
Nationality | British |
Other names | Dick Passingham |
Education | Shrewsbury School |
Alma mater |
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Scientific career | |
Fields | Neuroscience |
Institutions | University of Oxford Wellcome Trust Centre for Neuroimaging, UCL |
Notable students | John Aggleton Matthew Rushworth |
Richard Edward Passingham FRS (born 16 August 1943) is a British neuroscientist. He is an international authority on the frontal lobe mechanisms for decision making and executive control. He is amongst the most highly cited neuroscientists. [1]
He was educated at Shrewsbury School and Balliol College, Oxford. Passingham studied for an undergraduate degree in Psychology and Philosophy in 1966 followed in 1967 by a MSc in Abnormal Psychology at the Maudsley Hospital, London. In 1970, he undertook his examination for promotion to Doctor of Philosophy at the University of London.
Passingham is currently Emeritus Professor of Cognitive Neuroscience at the Department of Experimental Psychology, University of Oxford, [2] and is also an Emeritus Fellow of Wadham College, Oxford. [3] In addition, he is Emeritus Honorary Principal Investigator at the Wellcome Centre for Human Neuroimaging at University College London. [4] His career has been spent at these two institutions, and from 1991 to 1995 also at the MRC Cyclotron Unit at the Hammersmith Hospital London. He has published over 200 research papers [5] and eight books (listed below).
Passingham has transformed our view of the frontal lobes by his work on the monkey and human brain. He carried out early classical studies on the prefrontal cortex in primates, and pioneered our understanding of the premotor and supplementary motor cortex. Together with his later work using brain imaging in humans, he has changed our view of the fundamental role of the prefrontal cortex. He was at the forefront of extending the use of brain imaging from anatomical 'mapping' into physiology. He demonstrated general principles by which the system works as a whole, for example, that the contribution of an area to a task is not static, and that the same area can interact dynamically with one subsystem in one context and with another subsystem in another context.
The workings of the system depend on its anatomical connections. Therefore, Passingham's work is firmly based on these connections. He demonstrated that each cortical area has a unique set of inputs and outputs, and has argued that it is these that mainly determine the functions of the area. However, his work also shows that there are 'families' of areas that show similarities in their inputs and outputs, and these form systems. The anatomical connections that he charted in the macaque brain formed the basis for the anatomical models that he has tested in imaging studies of the human brain, devoted to understanding how one area influences another, for example using structural equation modelling.
Passingham started by investigating each area of the frontal lobes in macaques, and his earlier findings were summarised in his seminal book 'The Frontal Lobes and Voluntary Action' (1993). When brain imaging became available for studies of the human brain, Passingham was amongst the first to use it. He carried out PET studies from 1988 at the Hammersmith Hospital and fMRI studies from 1995 at the Wellcome Trust Centre for Neuroimaging (UCL), [4] where he was among the founding Principal Investigators of the Centre. Thus, for much of his career he had a research group working in Oxford with macaques and rTMS in humans, and a group working with brain imaging of humans in London.
He was elected a Fellow of the Royal Society in 2009 in recognition of his achievements.
Evolution of the brain and especially the human brainu
Prefrontal Cortex
Brain Imaging
Cognitive Neuroscience
Computational Neuroscience
Prefontal Cortex
(OUP, 2021)
Cognitive neuroscience is the scientific field that is concerned with the study of the biological processes and aspects that underlie cognition, with a specific focus on the neural connections in the brain which are involved in mental processes. It addresses the questions of how cognitive activities are affected or controlled by neural circuits in the brain. Cognitive neuroscience is a branch of both neuroscience and psychology, overlapping with disciplines such as behavioral neuroscience, cognitive psychology, physiological psychology and affective neuroscience. Cognitive neuroscience relies upon theories in cognitive science coupled with evidence from neurobiology, and computational modeling.
Cognitive neuropsychology is a branch of cognitive psychology that aims to understand how the structure and function of the brain relates to specific psychological processes. Cognitive psychology is the science that looks at how mental processes are responsible for the cognitive abilities to store and produce new memories, produce language, recognize people and objects, as well as our ability to reason and problem solve. Cognitive neuropsychology places a particular emphasis on studying the cognitive effects of brain injury or neurological illness with a view to inferring models of normal cognitive functioning. Evidence is based on case studies of individual brain damaged patients who show deficits in brain areas and from patients who exhibit double dissociations. Double dissociations involve two patients and two tasks. One patient is impaired at one task but normal on the other, while the other patient is normal on the first task and impaired on the other. For example, patient A would be poor at reading printed words while still being normal at understanding spoken words, while the patient B would be normal at understanding written words and be poor at understanding spoken words. Scientists can interpret this information to explain how there is a single cognitive module for word comprehension. From studies like these, researchers infer that different areas of the brain are highly specialised. Cognitive neuropsychology can be distinguished from cognitive neuroscience, which is also interested in brain-damaged patients, but is particularly focused on uncovering the neural mechanisms underlying cognitive processes.
The frontal lobe is the largest of the four major lobes of the brain in mammals, and is located at the front of each cerebral hemisphere. It is parted from the parietal lobe by a groove between tissues called the central sulcus and from the temporal lobe by a deeper groove called the lateral sulcus. The most anterior rounded part of the frontal lobe is known as the frontal pole, one of the three poles of the cerebrum.
Brodmann area 10 is the anterior-most portion of the prefrontal cortex in the human brain. BA10 was originally defined broadly in terms of its cytoarchitectonic traits as they were observed in the brains of cadavers, but because modern functional imaging cannot precisely identify these boundaries, the terms anterior prefrontal cortex, rostral prefrontal cortex and frontopolar prefrontal cortex are used to refer to the area in the most anterior part of the frontal cortex that approximately covers BA10—simply to emphasize the fact that BA10 does not include all parts of the prefrontal cortex.
Brodmann area 46, or BA46, is part of the frontal cortex in the human brain. It is between BA10 and BA45.
In philosophy of mind, neuroscience, and cognitive science, a mental image is an experience that, on most occasions, significantly resembles the experience of "perceiving" some object, event, or scene, but occurs when the relevant object, event, or scene is not actually present to the senses. There are sometimes episodes, particularly on falling asleep and waking up, when the mental imagery may be dynamic, phantasmagoric and involuntary in character, repeatedly presenting identifiable objects or actions, spilling over from waking events, or defying perception, presenting a kaleidoscopic field, in which no distinct object can be discerned. Mental imagery can sometimes produce the same effects as would be produced by the behavior or experience imagined.
In mammalian brain anatomy, the prefrontal cortex (PFC) covers the front part of the frontal lobe of the cerebral cortex. The PFC contains the Brodmann areas BA8, BA9, BA10, BA11, BA12, BA13, BA14, BA24, BA25, BA32, BA44, BA45, BA46, and BA47.
Edmund T. Rolls is a neuroscientist and Professor at the University of Warwick.
In cognitive science and neuropsychology, executive functions are a set of cognitive processes that are necessary for the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of chosen goals. Executive functions include basic cognitive processes such as attentional control, cognitive inhibition, inhibitory control, working memory, and cognitive flexibility. Higher-order executive functions require the simultaneous use of multiple basic executive functions and include planning and fluid intelligence.
The orbitofrontal cortex (OFC) is a prefrontal cortex region in the frontal lobes of the brain which is involved in the cognitive process of decision-making. In non-human primates it consists of the association cortex areas Brodmann area 11, 12 and 13; in humans it consists of Brodmann area 10, 11 and 47.
Frontal lobe disorder, also frontal lobe syndrome, is an impairment of the frontal lobe of the brain due to disease or frontal lobe injury. The frontal lobe plays a key role in executive functions such as motivation, planning, social behaviour, and speech production. Frontal lobe syndrome can be caused by a range of conditions including head trauma, tumours, neurodegenerative diseases, neurodevelopmental disorders, neurosurgery and cerebrovascular disease. Frontal lobe impairment can be detected by recognition of typical signs and symptoms, use of simple screening tests, and specialist neurological testing.
Developmental cognitive neuroscience is an interdisciplinary scientific field devoted to understanding psychological processes and their neurological bases in the developing organism. It examines how the mind changes as children grow up, interrelations between that and how the brain is changing, and environmental and biological influences on the developing mind and brain.
The dorsolateral prefrontal cortex is an area in the prefrontal cortex of the primate brain. It is one of the most recently derived parts of the human brain. It undergoes a prolonged period of maturation which lasts into adulthood. The DLPFC is not an anatomical structure, but rather a functional one. It lies in the middle frontal gyrus of humans. In macaque monkeys, it is around the principal sulcus. Other sources consider that DLPFC is attributed anatomically to BA 9 and 46 and BA 8, 9 and 10.
Patricia Goldman-Rakic was an American professor of neuroscience, neurology, psychiatry and psychology at Yale University School of Medicine. She pioneered multidisciplinary research of the prefrontal cortex and working memory.
In human neuroanatomy, brain asymmetry can refer to at least two quite distinct findings:
Anna Christina Nobre FBA, MAE, fNASc is a Brazilian and British cognitive neuroscientist working at the University of Oxford in England.
In neuroscience, functional specialization is a theory which suggests that different areas in the brain are specialized for different functions.
Social cognitive neuroscience is the scientific study of the biological processes underpinning social cognition. Specifically, it uses the tools of neuroscience to study "the mental mechanisms that create, frame, regulate, and respond to our experience of the social world". Social cognitive neuroscience uses the epistemological foundations of cognitive neuroscience, and is closely related to social neuroscience. Social cognitive neuroscience employs human neuroimaging, typically using functional magnetic resonance imaging (fMRI). Human brain stimulation techniques such as transcranial magnetic stimulation and transcranial direct-current stimulation are also used. In nonhuman animals, direct electrophysiological recordings and electrical stimulation of single cells and neuronal populations are utilized for investigating lower-level social cognitive processes.
Matthew F. S. Rushworth is Watts Professor of Experimental Psychology at the University of Oxford where his laboratory is funded by the Wellcome Trust and Medical Research Council.
Antoine Bechara is an American neuroscientist, academic and researcher. He is currently a professor of Psychology and Neuroscience at the University of Southern California.
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