Richard T. Johnson was a physician and scientist at the Johns Hopkins University School of Medicine. Johnson was a faculty member in the Department of Neurology since its inception in 1969 and was the former head of the department. His research into the effects of viruses on the central nervous system has been published in over 300 scientific articles, and Johnson was both a journal and book editor and the author of an influential textbook, Viral Infections of the Nervous System. [1]
Johnson, who was raised in Colorado, received his undergraduate degree cum laude from the University of Colorado in Boulder in 1953. He remained in Colorado to earn his medical degree in 1956 at the University of Colorado School of Medicine in Aurora, Colorado. He interned in internal medicine at Stanford University.
From 1957 to 1959, Johnson conducted research at the Walter Reed Army Institute of Research, Department of Virus Diseases, in Washington, DC. Johnson completed his residency in neurology at Harvard Medical School and Massachusetts General Hospital. He conducted research at the Institute of Advanced Studies at the Australian National University from 1962 to 1964. [2]
Johnson's first faculty appointment was as an assistant, then associate, professor of neurology at Case Western Reserve University.
In 1969, Johnson moved to the Johns Hopkins School of Medicine, accepting the Dwight D. Eisenhower Professorship of Neurology and founding a new Department of Neurology with Guy McKhann. Johnson was director of the department from 1988 until 1997 and remains a faculty member. He is also a professor of microbiology in the Department of Molecular Biology and Genetics and holds a joint appointment in the Department of Immunology and Infectious Diseases at the Johns Hopkins Bloomberg School of Public Health. Johnson has been a visiting professor at universities in Peru, Thailand, Iran, and Germany.
Johnson was on the staff of the Johns Hopkins Hospital and until 1997 was Neurologist-in Chief at the Johns Hopkins Hospital. He was certified by the American Board of Psychiatry and Neurology in 1966.
In 1997, Johnson became the founding director of the National Neuroscience Institute of Singapore, which he directed until 2000. He also assumed editorship of the Annals of Neurology.
Johnson's monograph Viral Infections of the Nervous System was published in 1982. A second edition followed in 1998.
During his career, Johnson had supervised the post-doctoral training of many notable scientists, including Janice E. Clements, Diane Griffin, and Opendra "Bill" Narayan.
Johnson died of [3] pneumonia November 22, 2015, at Johns Hopkins Hospital.
Throughout his career, Johnson had contributed to understanding of infections of the central nervous system.
Johnson met D. Carleton Gajdusek, 1976 Nobel Prize winner for his work on transmissible spongiform encephalopathies (TSEs, or prion diseases), while working at Walter Reed in the 1950s. In 1964, Johnson himself observed a case of Kuru, a prion disease, in Papua New Guinea. When Johnson became a professor at Johns Hopkins, his lab held joint lab meetings with Gajdusek's lab. Johnson helped to examine the first chimpanzee to show signs of Kuru after Gajdusek experimentally inoculated it with brain matter from a human victim. Johnson later chaired a US Institute of Medicine committee on TSEs. The committee released a report in 2004, stressing the need for further and expanded research into prion diseases [4] [5]
Johnson's honors and awards include:
Stanley Ben Prusiner is an American neurologist and biochemist. He is the director of the Institute for Neurodegenerative Diseases at University of California, San Francisco (UCSF). Prusiner discovered prions, a class of infectious self-reproducing pathogens primarily or solely composed of protein, considered by many as a heretical idea when first proposed. He received the Albert Lasker Award for Basic Medical Research in 1994 and the Nobel Prize in Physiology or Medicine in 1997 for prion research developed by him and his team of experts beginning in the early 1970s.
Transmissible spongiform encephalopathies (TSEs) also known as prion diseases, are a group of progressive, incurable, and fatal conditions that are associated with prions and affect the brain and nervous system of many animals, including humans, cattle, and sheep. According to the most widespread hypothesis, they are transmitted by prions, though some other data suggest an involvement of a Spiroplasma infection. Mental and physical abilities deteriorate and many tiny holes appear in the cortex causing it to appear like a sponge when brain tissue obtained at autopsy is examined under a microscope. The disorders cause impairment of brain function, including memory changes, personality changes and problems with movement that worsen chronically.
Daniel Carleton Gajdusek was an American physician and medical researcher who was the co-recipient of the Nobel Prize in Physiology or Medicine in 1976 for work on the transmissibility of kuru, implying the existence of an infectious agent, which he named an 'unconventional virus'.
Jaap Goudsmit is Dutch scientist, known for his research in the field of AIDS and influenza. He shifted his research interest to aging and neurodegenerative diseases, like Alzheimer's Disease. He is also a prolific writer of non-fiction books: Viral Sex, the Nature of AIDS (1997); Viral Fitness, the Next SARS and West Nile in the Making (2004); Serendipity Manual (2012); The Vaccine Bug, a personal history of the World of Immunity (2013); Immorbidity Alphabet, Spelling-out a life free of dis-ease (2015); The Time of your Life, Staying healthy to the End (2016) and The Art of Facing Mortality, a scientist's view (2016).
Endocannibalism is a practice of cannibalism in one's own locality or community. In most cases this refers to the consumption of the remains of the deceased in a mortuary context.
Kuru is a rare, incurable, and fatal neurodegenerative disorder that was formerly common among the Fore people of Papua New Guinea. Kuru is a form of transmissible spongiform encephalopathy (TSE) caused by the transmission of abnormally folded proteins (prions), which leads to symptoms such as tremors and loss of coordination from neurodegeneration.
A neurotropic virus is a virus that is capable of infecting nerve tissue.
Janice Ellen Clements is vice dean for faculty at the Johns Hopkins School of Medicine and the Mary Wallace Stanton Professor of Faculty Affairs. She is a professor in the departments of Molecular and Comparative Pathobiology, Neurology, and Pathology, and has a joint appointment in molecular biology and genetics. Her molecular biology and virology research examines lentiviruses and how they cause neurological diseases.
Diane Edmund Griffin is the university distinguished professor and a professor in the Department of Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health, where she was the department chair from 1994-2015. She is also the current vice-president of the National Academy of Sciences. She holds joint appointments in the departments of Neurology and Medicine. In 2004, Griffin was elected to the United States National Academy of Sciences (NAS) in the discipline of microbial biology.
Opendra "Bill" Narayan was an HIV/AIDS researcher at the Johns Hopkins School of Medicine and the University of Kansas Medical Center. A veterinarian, Narayan researched animal models of HIV. His focus on finding a vaccine for retroviral infection had some success against a monkey retrovirus, SIV, and he is best known for engineering a type of HIV that could cause AIDS-like disease in monkeys.
Neurovirology is an interdisciplinary field which represents a melding of clinical neuroscience, virology, immunology, and molecular biology. The main focus of the field is to study viruses capable of infecting the nervous system. In addition to this, the field studies the use of viruses to trace neuroanatomical pathways, for gene therapy, and to eliminate detrimental populations of neural cells.
Avindra "Avi" Nath, is a physician-scientist who specializes in neuroimmunology. Nath is a senior investigator, and intramural clinical director of the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH) in the United States. At NINDS, Nath also leads the Section of Infections of the Nervous System and plans to institute a translational research center. He previously served in several research and administrative positions at the Johns Hopkins Hospital and the Johns Hopkins University School of Medicine.
Joseph R. Berger is an American internist and neurologist who is known for his research interests in progressive multifocal leukoencephalopathy (PML), the neurological complications of HIV/AIDS, multiple sclerosis, and other inflammatory disorders of the brain. Particularly, he contributed research on why PML occurs more frequently in AIDS than in other immunosuppressive conditions.
The International Society for NeuroVirology (ISNV) was founded to promote research into disease-causing viruses that infect the human brain and nervous system. The ISNV membership includes scientists and clinicians from around the world who work in the fields of basic, translational, and clinical neurovirology.
Thomas Solomon is Professor of Neurology at the University of Liverpool, director of The Pandemic Institute and director of the National Institute for Health and Care Research (NIHR) Health Protection Research Unit in Emerging and Zoonotic Infections. He is also Vice President (International) of the Academy of Medical Sciences.
The Liverpool Neurological Infectious Diseases Course is an annual two-day course aimed at medical professionals and students with an interest in neurological infectious diseases. The course is organised by the Liverpool Brain Infections Group, a division of the Institute of Infection and Global Health at the University of Liverpool, in collaboration with the Walton Centre NHS Foundation Trust, Alder Hey Children’s NHS Trust, Royal Liverpool University Hospital, and Liverpool School of Tropical Medicine, and is chaired by the neurologist Tom Solomon. It takes place during May at the historic Liverpool Medical Institution, in Liverpool, UK. A variety of both national and international speakers contribute to a programme which covers clinical aspects of common central nervous system infections such as meningitis and encephalitis, as well as rarer neurological infections and talks on recent advances in related research. The course is accredited by the UK Royal College of Physicians, and attracts delegates from many countries worldwide.
Rajiv Ratan is an Indian American academic, professor, administrator and scientist based in New York. He is the Burke Professor of Neurology and Neuroscience at Weill Cornell Medicine. Since 2003, he has served as the executive director of Burke Neurological Institute and as a member of the Council of Affiliated Deans of Weill Cornell Medicine.
Igor Koralnik is an American physician, neurologist and scientist. He is one of the first physicians to study the neurologic complications caused by the human immunodeficiency virus (HIV) and is a leading researcher in the investigation of the polyomavirus JC, which causes progressive multifocal leukoencephalopathy (PML), a disease of the central nervous system that occurs in immunosuppressed individuals.
Amanda Brown is an American immunologist and microbiologist as well as an associate professor of neurology and neuroscience at Johns Hopkins University School of Medicine in Baltimore, Maryland. Brown is notable for cloning one of the first recombinant HIV viruses and developing a novel method to visualize HIV infected cells using GFP fluorescence.
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