The Institute takes its name from MajorWalter Reed, MD (1851–1902), the Army physician who, in 1901, led the team that confirmed the theory that yellow fever is transmitted by a particular mosquito species, rather than by direct contact. Today, the WRAIR fosters and performs biomedical research for the DoD and the US Army. It has recently developed two modern "Centers of Excellence" in the fields of military psychiatry/neuroscience and infectious disease research. The Centers focus, respectively, on soldier fitness, brain injury, and sleep management and in the development of vaccines and drugs for prevention and treatment of such diseases as malaria, HIV/AIDS, dengue fever, wound infections, leishmaniasis, enteric diseases.
Official mandate
Basic and applied medical research supporting U.S. military operations is the focus of WRAIR leaders and scientists. Despite the focus on the military, however, the institute has historically also addressed and solved a variety of non-military medical problems prevalent in the United States and the wider world.[citation needed]
Divisions and Subordinate Units of the WRAIR
Divisions at the Daniel K. Inouye Building
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The Walter Reed Army Institute of Research hosts two Centers of Excellence for Military Psychiatry and Neuroscience and for Infectious Disease Research which are headquartered in Silver Spring, Maryland.
Office of Science Education and Strategic Communications:
Research Marketing
Gains in Education of Mathematics & Science (GEMS)
Students in 7th to 12th grade get an opportunity to participate in an internship for one to four weeks in an Army laboratory and learn technical skills. Advanced courses in subsequent years build upon prior experience.
Science & Engineering Apprentice Program (SEAP)
A cooperative education (work/study) program for high school students looking at a possible career in science and engineering. The program offers hands-on experience and mentoring in Army research and development activities in an actual Army laboratory.
Paid internships for undergraduates seeking experience in Army research.
The WRAIR supports and collaborates on all other Army Educational Research Programs including the Mobile Discovery Center, the Junior Solar Spring, eCybermission, Uninitiates Introduction to Engineering (UNITE), Research & Engineering Apprentice Program (REAP), International Science & Engineering Fair (INTEL-ISEF), Internships Science & Engineering Program (ISEP), Junior Science & Humanities Symposium (JSHS), Women in Science Project (WISP), Career Related Experience in Science & Technology (CREST), Consortium Research Fellows Program (CRFP), and Science, Mathematics and Research for Transformation Defense Scholarshop for Service Program (SMART).
Research Support:
Preventive Medicine and Pathology
Pilot Bioproduction Facility
Clinical Trials Center
Veterinary Medicine
Division of Human Subjects Protection
DMAVS, Library and Statistical Services
Information Management
Logistics
Office of Quality Activities
Operations and Security
Personnel
Resource Management
Safety
WRAIR Pilot Bioproduction Facility
The Pilot Bioproduction Facility (PBF) was established in 1958 as the Department of Biologics Research and is now located at the Walter Reed Army Institute of Research. The PBF mission is research, development, production, and testing of vaccines for human use.[2] The PBF at the Forest Glen Annex is a multi-use facility designed and operated for production of vaccines in compliance with the current Good Manufacturing (cGMP) regulations. Compliance with cGMP ensures that products prepared in the facility will be safe, potent, and reproducible.
Since inception, the PBF has specialized in developing vaccines for Department of Defense mission-related disease threats. The PBF follows all federal regulations that apply to biological products and has expertise in the development and production of vaccines for the prevention of a variety of infectious diseases. Projects for public and private partners are accomplished through inter-agency and cooperative agreements.
Vaccines are produced that will protect Soldiers against diseases that they might encounter in areas of deployment. These include vaccines to prevent dengue fever, malaria, meningitis, cholera, shigellosis, hepatitis A, and HIV. The PBF places compliance, cleanliness, and safety as top priorities in the production process of a vaccine. Once the vaccine is tested for safety, potency, and identity, the vaccine is released for use in approved human clinical studies. Several of the PBF's experimental vaccines have progressed on to advanced clinical testing.[citation needed]
Global Platforms
United States Army Medical Research Directorate - West (USAMRD-W)
The Walter Reed Army Medical Center (WRAMC), officially known as Walter Reed General Hospital (WRGH) until 1951, was the U.S. Army's flagship medical center from 1909 to 2011. Located on 113 acres (46 ha) in Washington, D.C., it served more than 150,000 active and retired personnel from all branches of the United States Armed Forces. The center was named after Walter Reed, a U.S. Army physician and sergeant who led the team that confirmed that yellow fever is transmitted by mosquitoes rather than direct physical contact.
Tropical medicine is an interdisciplinary branch of medicine that deals with health issues that occur uniquely, are more widespread, or are more difficult to control in tropical and subtropical regions.
Joseph Edward Smadel (1907–1963) was a U.S. medical doctor and virologist. He introduced chloramphenicol as treatment for rickettsial diseases. In 1962, he became the first recipient of the Albert Lasker Award for Clinical Medical Research.
Uniformed Services University of the Health Sciences (USU) is a health science university of the U.S. federal government. The primary mission of the school is to prepare graduates for service to the U.S. at home and abroad as uniformed health professionals, scientists and leaders; by conducting cutting-edge, military-relevant research; by leading the Military Health System in key functional and intellectual areas; and by providing operational support to units around the world.
Psychiatric and mental health nurses in the U.S. Army Nurse Corps employing groundbreaking protocols and treatments in psychiatric issues to address the unique challenges that our service men and women face, more commonly post-traumatic stress disorder and traumatic brain injuries. Most people understand that trauma exposure is a popular occupational hazard for military members. Psychiatric screenings, before and during their enlistment, and treatments after being exposed to warfare, death, destruction, and torture have been extremely beneficial for military personnel and their dependents.
Abram Salmon Benenson was an authority in public health, preventive medicine, military medicine, and "shoe-leather" epidemiology. He was best known as the editor-in-chief for the Control of Communicable Diseases Manual of the American Public Health Association. His tenure as editor was so lengthy that the manual was often known as the "Benenson Book".
The term military medicine has a number of potential connotations. It may mean:
The United States Army Medical Research and Development Command (USAMRDC) is the United States Army's medical materiel developer, with responsibility for medical research, development, and acquisition.
The Forest Glen Annex is a 136-acre (0.55 km2) U.S. Army installation in the Forest Glen Park neighborhood of Silver Spring, Maryland, United States. It is situated between Brookville Road and Linden Lane. Since 1999, the Annex has been the site of the Walter Reed Army Institute of Research (WRAIR) and the Naval Medical Research Center (NMRC), along with smaller units.
Gregory J. Martin is an American medical doctor and captain in the United States Navy. Martin is a recognized expert in the fields of infectious diseases and bioterrorism.
The Pilot Bioproduction Facility of the Walter Reed Army Institute of Research (WRAIR) is a Contract Manufacturing Organization (CMO) facility whose mission is to perform vaccine production on a pilot scale. The facility produces pre-license Phase I vaccine candidates under cGMP conditions using both bacterial and viral based technology. It is located at the Forest Glen Annex of the Walter Reed Army Institute of Research in Silver Spring, Maryland. Its business methodology is to work with government agencies through interagency agreements and with private companies through CRADAs in order to produce vaccine candidates. Its manufacturing capabilities include bacterial and viral seed banking, fermentation, purification, and aseptic filling. The facility can perform whole campaigns from beginning to end or any individual function listed above under GMP conditions. The facility also has the capability to perform different viral titer assays on a contracted basis. The Facility has a Type V Facility Master File on file with the U.S. Food and Drug Administration.
The United States Military HIV Research Program was initiated by the United States Congress in 1986, in reaction to the threat of lost effectiveness of U.S./Allied troops due to HIV infection. The mission of MHRP is to develop an HIV-1 vaccine, provide prevention, care, and treatment, and conduct meaningful HIV/AIDS research for the global community through the President's Emergency Plan for AIDS Relief (PEPFAR). It is centered at the Walter Reed Army Institute of Research (WRAIR), and has established five international research sites in Africa and Asia. MHRP also partners with the Armed Forces Research Institute of Medical Sciences (AFRIMS) in Thailand. MHRP works closely with The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF), most notably in the development of the RV144 HIV vaccine in Thailand. MHRP is the largest research program supported by the HJF.
The Walter Reed Tropical Medicine Course at Walter Reed Army Institute of Research (WRAIR) is one of the many Tropical Medicine Training Courses available in the US and worldwide. It is an intensive 5-day course and a 3-day short course, created to familiarize students with tropical diseases they may encounter overseas. The course is open to Physicians, Physician Assistants, Nurse Practitioners, ESO, 18D, or other medical personnel. The course is run by the military and designed for personnel of the US Military and several other US government agencies.
Naval Medical Research Unit SOUTH, formerly known as Naval Medical Research Unit Six, is a biomedical research laboratory of the U.S. Navy located in Lima, Peru. It is the only U.S. military command located in South America. Its mission is to identify infectious disease threats of military and public health importance and to develop and evaluate interventions and products to mitigate those threats.
Makerere University Walter Reed Project (MUWRP) was established in 2002 for the primary purpose of HIV vaccine development and building of vaccine testing capability in Uganda. It is one of the 5 international research sites established by the Department of Defense (DoD) United States HIV Research Program (MHRP), a program centered at the Walter Reed Army Institute of Research (WRAIR) in Silver Spring, Maryland. MUWRP's main facility is centrally located in Kampala, near the Makerere University College of Health Sciences where the MUWRP laboratory is located. The main facility includes the clinic, administrative, and data offices.
The Naval Medical Research Command (NMRC) is an agency that performs basic and applied biomedical research to meet the needs of the United States Navy and United States Marine Corps. Its areas of focus include study of infectious diseases, biodefense, military medicine, battlefield medicine, and bone marrow research. NMRC is under the United States Department of the Navy's Bureau of Medicine and Surgery.
David McKenzie Rioch was a psychiatric research scientist and neuroanatomist, known as a pioneer in brain research and for leading the interdisciplinary neuropsychiatry division at the Walter Reed Army Institute of Research (1951–1970), a program that contributed to the formation of the then-nascent field of neuroscience.
The Armed Forces Research Institute of Medical Sciences (AFRIMS) is a United States Army project that started as a collaboration with the Government of Thailand to fight a cholera outbreak in Bangkok in 1958 and 1959. It subsequently expanded to conduct military medical research, primarily involving infectious diseases, across much of Southeast Asia and the Indian Subcontinent.
Nelson L. Michael is an American infectious disease researcher. He has served for nearly 30 years in the United States Army and been directly involved with significant advancements in understanding the pathology of and vaccine development for diseases like HIV, Zika, Ebola and more. Much of his career has been spent at the Walter Reed Army Institute of Research.
John R. Mascola is an American physician-scientist, immunologist and infectious disease specialist. He was the director of the Vaccine Research Center (VRC), part of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). He also served as a principal advisor to Anthony Fauci, director of NIAID, on vaccines and biomedical research affairs. Mascola is the current Chief Scientific Officer for ModeX Therapeutics.
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