Robert L. McNeil Jr. | |
---|---|
With AIC Gold Medal, 2005 | |
Born | |
Died | May 20, 2010 94) | (aged
Nationality | American |
Alma mater | Yale University, Philadelphia College of Pharmacy and Science |
Spouse | Nancy McKinney Jones |
Awards | American Institute of Chemists Gold Medal |
Scientific career | |
Fields | Chemist |
Robert Lincoln McNeil Jr. (July 13, 1915 – May 20, 2010) was an American chemist and pharmaceutical industry executive. He was responsible for, among other things, the commercial development, naming, and introduction of the pain reliever Tylenol. [1] [2]
McNeil was born in Bethel, Connecticut, on July 13, 1915, and was raised in the Germantown neighborhood of Philadelphia. He earned two undergraduate degrees, the first in 1936 from Yale University, where he majored in physiological chemistry and bacteriology, after which he started working part-time at the family's pharmaceutical business, McNeil Laboratories, Inc., which was run by his father, R. Lincoln McNeil. He earned a second bachelor's degree in 1938, this from the Philadelphia College of Pharmacy and Science. [1]
After completing college in 1938, he joined McNeil Laboratories full-time, coming on board to what had been the family business for three generations having been founded in 1879. [1] The company had been founded as a corner drug store and had grown into selling medicines on a commercial basis. [3] He began the process of transforming the company, adding a research and development group to develop new prescription medications and restructuring the array of products being offered for sale. [1]
To compete with the aspirin products sold by his company's competitors and having heard of work being done on the chemical by researchers, McNeil started in 1951 pursuing the development of what he named "acetaminophen", a chemical that had been discovered decades earlier but was little tested at the time as a pain reliever. [1] The chemical's name N-acetyl-p-aminophenol was the source for the generic name "acetaminophen" (N-acetyl-p-aminophenol) coined by McNeil, as well as of the brand name "Tylenol" (N-acetyl-p-aminophenol), which was coined by a colleague. [3] McNeil recognized that high production costs would mean that the product would have to sell at a higher price than the commonly available aspirin, but that it would have the benefit of not causing stomach irritation. [1] [4] Tylenol was initially approved by the United States Food and Drug Administration in 1955 for sale on a prescription basis, and became available for sale to consumers over the counter in 1960. Elixir Tylenol, a liquid medicine advertised "for little hotheads" went on sale as the first product bearing the Tylenol brand name. McNeil was named chairman of McNeil in 1956 and he remained as chairman of the company after it was purchased in 1960 by Johnson & Johnson for $30 million in stock and was operated as a subsidiary of that firm. [1] [3] [5]
On September 11, 2001, McNeil donated an original copy of the first public print of the Constitution, published in the Pennsylvania Packet on September 19, 1787, to the National Constitution Center. [6]
In 2006, the Philadelphia Museum of Art exhibited 50 pieces of presidential china that McNeil donated to the museum, part of a collection of 450 pieces that ranged from the presidencies of George Washington through Ronald Reagan. The collection includes a large number of pieces of the rare Lincoln china service. [7] The collection was described by The New York Times as being "considered one of the most important outside the White House". [8]
McNeil also created the Barra Foundation, dedicating to helping non-profits to improve life in the greater Philadelphia area. [9] [10]
McNeil died of heart failure at age 94 on May 20, 2010, at his Wyndmoor, Pennsylvania, home. He was survived by his wife, the former Nancy McKinney Jones, as well as by two daughters, two sons and 11 grandchildren. [1]
Paracetamol is a non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely used over the counter medication. Common brand names include Tylenol and Panadol.
Tylenol is a brand of medication, advertised for reducing pain, reducing fever, and relieving the symptoms of allergies, cold, cough, headache, and influenza. The active ingredient of its original flagship product is paracetamol, an analgesic and antipyretic. Like the words paracetamol and acetaminophen, the brand name Tylenol is derived from a chemical name for the compound, N-acetyl-para-aminophenol (APAP). The brand name is owned by McNeil Consumer Healthcare, a subsidiary of Kenvue.
Wyndmoor is a census-designated place (CDP) in Springfield Township, Montgomery County, Pennsylvania, United States. The population was 5,498 at the 2010 census. Wyndmoor has the same ZIP code, 19038, as the towns of Glenside, North Hills, and Erdenheim.
A patent medicine is a non-prescription medicine or medicinal preparation that is typically protected and advertised by a trademark and trade name, and claimed to be effective against minor disorders and symptoms, as opposed to a prescription drug that could be obtained only through a pharmacist, usually with a doctor's prescription, and whose composition was openly disclosed. Many over-the-counter medicines were once ethical drugs obtainable only by prescription, and thus are not patent medicines.
Arnold Orville Beckman was an American chemist, inventor, investor, and philanthropist. While a professor at California Institute of Technology, he founded Beckman Instruments based on his 1934 invention of the pH meter, a device for measuring acidity, later considered to have "revolutionized the study of chemistry and biology". He also developed the DU spectrophotometer, "probably the most important instrument ever developed towards the advancement of bioscience". Beckman funded the Shockley Semiconductor Laboratory, the first silicon transistor company in California, thus giving rise to Silicon Valley. After retirement, he and his wife Mabel (1900–1989) were numbered among the top philanthropists in the United States.
The Chicago Tylenol murders were a series of poisoning deaths resulting from drug tampering in the Chicago metropolitan area in 1982. The victims consumed Tylenol-branded acetaminophen capsules that had been laced with potassium cyanide. Seven people died in the original poisonings, and there were several more deaths in subsequent copycat crimes.
Phenacetin is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s.
Acetanilide is an odourless solid chemical of leaf or flake-like appearance. It is also known as N-phenylacetamide, acetanil, or acetanilid, and was formerly known by the trade name Antifebrin.
Ernest Henry Volwiler was an American chemist. He spent his career at Abbott Laboratories working his way from staff chemist to CEO. He was a pioneer in the field of anesthetic pharmacology, assisting in the development of two breakthrough drugs, Nembutal and Pentothal. Volwiler also helped Abbott Laboratories to achieve commercial success for its pharmaceutical products including the commercialization of penicillin and sulfa drugs during World War II.
McNeil Consumer Healthcare is an American medicals products company belonging to Kenvue consumer health group. It primarily sells fast-moving consumer goods such as over-the-counter drugs.
Codeine is an opiate and prodrug of morphine mainly used to treat pain, coughing, and diarrhea. It is also commonly used as a recreational drug. It is found naturally in the sap of the opium poppy, Papaver somniferum. It is typically used to treat mild to moderate degrees of pain. Greater benefit may occur when combined with paracetamol (acetaminophen) or a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin or ibuprofen. Evidence does not support its use for acute cough suppression in children or adults. In Europe, it is not recommended as a cough medicine in those under 12 years of age. It is generally taken by mouth. It typically starts working after half an hour, with maximum effect at two hours. Its effects last for about four to six hours. Codeine exhibits abuse potential similar to other opioid medications, including a risk of habituation and overdose.
George Oliver Curme Jr. was an American industrial chemist, working with the synthesis of various chemicals — including acetylene and ethylene glycol — from petroleum byproducts.
Aspirin, an organic compound that does not occur in nature, was first synthesised in 1899.
Sir William Jackson Pope was an English chemist.
The Science History Institute is an institution that preserves and promotes understanding of the history of science. Located in Philadelphia, Pennsylvania, it includes a library, museum, archive, research center and conference center.
Kathryn "Kitty" Hach-Darrow was an American businesswoman and philanthropist who co-founded the Hach Chemical Company in 1947 with her first husband Clifford C. Hach. She was essential to the company's expansion, flying her own plane to small airfields across the country to sell water purification kits. She became president, chief operating officer, and CEO of the Hach company.
The Chemical Industry Medal is an annual American award given to an industrial chemist by the Society of Chemical Industry America. The medal has been awarded since 1933, when it replaced the Grasselli Medal. It was initially given to "a person making a valuable application of chemical research to industry. Primary consideration shall be given to applications in the public interest." As of 1945, the criterion became "a person who ... has rendered conspicuous service to applied chemistry." More recently it has been awarded "for contributions toward the growth of the chemical industry."
Arnold Thackray is an emeritus professor at the University of Pennsylvania. Initially an English chemist, he became an entrepreneurial American. Thackray founded or extended a series of institutions, initially in Philadelphia, then on a wider scale within the History of Science Society (HSS) and through Science History Consultants, and the Life Sciences Foundation.
Charles C. Price was an American chemist and president of the American Chemical Society (1965). He taught at the University of Illinois at Chicago, the University of Notre Dame, and the University of Pennsylvania.