SACM1L

SACM1L
Identifiers
Aliases	SACM1L , SAC1, SAC1 suppressor of actin mutations 1-like (yeast), SAC1 suppressor of actin mutations 1 like (yeast), SAC1 like phosphatidylinositide phosphatase
External IDs	OMIM: 606569; MGI: 1933169; HomoloGene: 6320; GeneCards: SACM1L; OMA:SACM1L - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 45,689,056 bp [1] End 45,745,409 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 F4|9 74.08 cM Start 123,358,824 bp [2] End 123,421,665 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Brodmann area 23 lateral nuclear group of thalamus pars reticulata endothelial cell pars compacta Epithelium of choroid plexus visceral pleura lower lobe of lung renal medulla Top expressed in deep cerebellar nuclei medial vestibular nucleus facial motor nucleus substantia nigra dorsal tegmental nucleus pontine nuclei lateral geniculate nucleus mammillary body Epithelium of choroid plexus Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatase activity phosphoric ester hydrolase activity phosphatidylinositol bisphosphate phosphatase activity protein binding hydrolase activity phosphatidylinositol-4-phosphate phosphatase activity phosphatidylinositol-3-phosphatase activity phosphatidylinositol phosphate 4-phosphatase activity Cellular component integral component of membrane Golgi membrane integral component of endoplasmic reticulum membrane Golgi apparatus AMPA glutamate receptor complex endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process phosphatidylinositol biosynthetic process phosphatidylinositol dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22908 83493 Ensembl ENSG00000211456 ENSMUSG00000025240 UniProt Q9NTJ5 Q9EP69 RefSeq (mRNA) NM_014016 NM_001319072 NM_001319073 NM_001319071 NM_030692 NM_001357485 RefSeq (protein) NP_001306001 NP_001306002 NP_054735 NP_001306000 NP_109617 NP_001344414 Location (UCSC) Chr 3: 45.69 – 45.75 Mb Chr 9: 123.36 – 123.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphatidylinositide phosphatase SAC1 is an enzyme that in humans is encoded by the SACM1L gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000211456 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025240 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
6. Kiss H, Kedra D, Kiss C, Kost-Alimova M, Yang Y, Klein G, Imreh S, Dumanski JP (May 2001). "The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3". Genomics. 73 (1): 10–9. doi:10.1006/geno.2000.6498. PMID   11352561.
7. "Entrez Gene: SACM1L SAC1 suppressor of actin mutations 1-like (yeast)".

Further reading

• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rohde HM, Cheong FY, Konrad G, et al. (2004). "The human phosphatidylinositol phosphatase SAC1 interacts with the coatomer I complex". J. Biol. Chem. 278 (52): 52689–99. doi: 10.1074/jbc.M307983200 . PMID   14527956.
• Zhong R, Ye ZH (2003). "The SAC domain-containing protein gene family in Arabidopsis". Plant Physiol. 132 (2): 544–55. doi:10.1104/pp.103.021444. PMC   166996 . PMID   12805586.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID   11214970.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Nemoto Y, Kearns BG, Wenk MR, et al. (2000). "Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity". J. Biol. Chem. 275 (44): 34293–305. doi: 10.1074/jbc.M003923200 . PMID   10887188.