SARDH

SARDH
Identifiers
Aliases	SARDH , BPR-2, DMGDHL1, SAR, SARD, SDH, sarcosine dehydrogenase
External IDs	OMIM: 604455; MGI: 2183102; HomoloGene: 5149; GeneCards: SARDH; OMA:SARDH - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.2 Start 133,663,560 bp [1] End 133,739,955 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A3 Start 27,078,405 bp [2] End 27,138,349 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver buccal mucosa cell body of pancreas corpus epididymis human kidney testicle granulocyte ventricular zone sural nerve ganglionic eminence Top expressed in left lobe of liver right kidney proximal tubule human kidney yolk sac external carotid artery major salivary gland parotid gland lip internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function oxidoreductase activity sarcosine dehydrogenase activity Cellular component mitochondrion mitochondrial matrix cytoplasm Biological process choline catabolic process sarcosine catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1757 192166 Ensembl ENSG00000123453 ENSMUSG00000009614 UniProt Q9UL12 Q99LB7 RefSeq (mRNA) NM_001134707 NM_007101 NM_138665 RefSeq (protein) NP_001128179 NP_009032 NP_619606 Location (UCSC) Chr 9: 133.66 – 133.74 Mb Chr 2: 27.08 – 27.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sarcosine dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the SARDH gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000123453 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009614 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Eschenbrenner M, Jorns MS (Nov 1999). "Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia". Genomics. 59 (3): 300–8. doi:10.1006/geno.1999.5886. PMID   10444331.
6. "Entrez Gene: SARDH sarcosine dehydrogenase".

Further reading

• Porter DH, Cook RJ, Wagner C (1986). "Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver". Arch. Biochem. Biophys. 243 (2): 396–407. doi:10.1016/0003-9861(85)90516-8. PMID   2417560.
• London RE, Gabel SA, Funk A (1988). "Metabolism of excess methionine in the liver of intact rat: an in vivo 2H NMR study". Biochemistry. 26 (22): 7166–72. doi:10.1021/bi00396a044. PMID   2447942.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Bergeron F, Otto A, Blache P, et al. (1998). "Molecular cloning and tissue distribution of rat sarcosine dehydrogenase". Eur. J. Biochem. 257 (3): 556–61. doi: 10.1046/j.1432-1327.1998.2570556.x . PMID   9839943.
• Gilbert JR, Kumar A, Newey S, et al. (2000). "Physical and cDNA mapping in the DBH region of human chromosome 9q34". Hum. Hered. 50 (3): 151–7. doi:10.1159/000022905. PMID   10686491. S2CID   43238824.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.