SEMG2

SEMG2
Identifiers
Aliases	SEMG2 , SGII, semenogelin II, semenogelin 2
External IDs	OMIM: 182141 HomoloGene: 129832 GeneCards: SEMG2
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 45,221,373 bp [1] End 45,224,458 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula sperm prostate metanephros kidney human musculoskeletal system muscular system muscle muscle female reproductive system n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protease binding protein binding metal ion binding zinc ion binding Cellular component extracellular region extracellular exosome nucleus extracellular space Biological process antibacterial humoral response positive regulation of serine-type endopeptidase activity protein heterooligomerization negative regulation of flagellated sperm motility coagulation sperm capacitation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6407 n/a Ensembl ENSG00000124157 n/a UniProt Q02383 n/a RefSeq (mRNA) NM_003008 n/a RefSeq (protein) NP_002999 n/a Location (UCSC) Chr 20: 45.22 – 45.22 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene. ^{[3] [4] [5]}

The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. ^[5]

See also

• Semenogelin

References

1. GRCh38: Ensembl release 89: ENSG00000124157 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Ulvsback M, Lazure C, Lilja H, Spurr NK, Rao VV, Loffler C, Hansmann I, Lundwall A (Oct 1992). "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20". J Biol Chem. 267 (25): 18080–4. doi: 10.1016/S0021-9258(19)37155-8 . PMID   1517240.
4. Peter A, Lilja H, Lundwall A, Malm J (Apr 1998). "Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase". Eur J Biochem. 252 (2): 216–21. doi: 10.1046/j.1432-1327.1998.2520216.x . PMID   9523691.
5. "Entrez Gene: SEMG2 semenogelin II".

Further reading

• Lilja H, Lundwall A (1992). "Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein". Proc. Natl. Acad. Sci. U.S.A. 89 (10): 4559–63. Bibcode:1992PNAS...89.4559L. doi: 10.1073/pnas.89.10.4559 . PMC   49122 . PMID   1584792.
• Schneider K, Kausler W, Tripier D, et al. (1989). "[Isolation and structure determination of two peptides occurring in human seminal plasma]". Biol. Chem. Hoppe-Seyler. 370 (4): 353–6. doi:10.1515/bchm3.1989.370.1.353. PMID   2757795.
• Lundwall A (1996). "The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA". Eur. J. Biochem. 235 (3): 466–70. doi: 10.1111/j.1432-1033.1996.00466.x . PMID   8654389.
• Malm J, Hellman J, Magnusson H, et al. (1996). "Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II". Eur. J. Biochem. 238 (1): 48–53. doi: 10.1111/j.1432-1033.1996.0048q.x . PMID   8665951.
• Kise H, Nishioka J, Kawamura J, Suzuki K (1996). "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor". Eur. J. Biochem. 238 (1): 88–96. doi: 10.1111/j.1432-1033.1996.0088q.x . PMID   8665956.
• Bjartell A, Malm J, Moller C, et al. (1997). "Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry". J. Androl. 17 (1): 17–26. doi:10.1002/j.1939-4640.1996.tb00582.x. PMID   8833737. S2CID   20337870.
• Ulvsbäck M, Lundwall A (1997). "Cloning of the semenogelin II gene of the rhesus monkey. Duplications of 360 bp extend the coding region in man, rhesus monkey and baboon". Eur. J. Biochem. 245 (1): 25–31. doi:10.1111/j.1432-1033.1997.00025.x. PMID   9128720.
• Lövgren J, Airas K, Lilja H (1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors". Eur. J. Biochem. 262 (3): 781–9. doi: 10.1046/j.1432-1327.1999.00433.x . PMID   10411640.
• Malm J, Hellman J, Hogg P, Lilja H (2000). "Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor". Prostate. 45 (2): 132–9. doi:10.1002/1097-0045(20001001)45:2<132::AID-PROS7>3.0.CO;2-3. PMID   11027412. S2CID   35309283.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Brillard-Bourdet M, Réhault S, Juliano L, et al. (2002). "Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates". Eur. J. Biochem. 269 (1): 390–5. doi: 10.1046/j.0014-2956.2001.02667.x . PMID   11784334.
• Lundwall A, Bjartell A, Olsson AY, Malm J (2003). "Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues". Mol. Hum. Reprod. 8 (9): 805–10. doi:10.1093/molehr/8.9.805. PMID   12200457.
• Ek P, Malm J, Lilja H, et al. (2003). "Exogenous protein kinases A and C, but not endogenous prostasome-associated protein kinase, phosphorylate semenogelins I and II from human semen". J. Androl. 23 (6): 806–14. doi:10.1002/j.1939-4640.2002.tb02337.x. PMID   12399526.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yoshida K, Yamasaki T, Yoshiike M, et al. (2004). "Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma". J. Androl. 24 (6): 878–84. doi: 10.1002/j.1939-4640.2003.tb03139.x . PMID   14581514.
• Jensen-Seaman MI, Li WH (2004). "Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen". J. Mol. Evol. 57 (3): 261–70. CiteSeerX   10.1.1.328.9582 . doi:10.1007/s00239-003-2474-x. PMID   14629036. S2CID   9728983.
• Dorus S, Evans PD, Wyckoff GJ, et al. (2005). "Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity". Nat. Genet. 36 (12): 1326–9. doi:10.1038/ng1471. PMID   15531881. S2CID   9122060.
• Jonsson M, Linse S, Frohm B, et al. (2005). "Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen". Biochem. J. 387 (Pt 2): 447–53. doi:10.1042/BJ20041424. PMC   1134973 . PMID   15563730.