SFRS16

CLASRP
Identifiers
Aliases	CLASRP , CLASP, SFRS16, SWAP2, CLK4 associating serine/arginine rich protein
External IDs	OMIM: 618532 GeneCards: CLASRP
Gene location (Human)
Chr.	Chromosome 19 (human)
End	45,070,956 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; sural nerve; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right lobe of liver; ; body of stomach; ; canal of the cervix; ; skin of abdomen; ; left uterine tube; ; spleen;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	nucleus ; nucleoplasm ;
Biological process	RNA splicing ; mRNA processing ;
	Sources:Amigo / QuickGO
Orthologs
	11129
	n/a
	ENSG00000104859
	n/a
	Q8N2M8
	n/a
	NM_001278439 ; NM_007056
	n/a
	NP_001265368 ; NP_008987 ; NP_008987.2
	n/a
	Wikidata
View/Edit Human

Last updated September 30, 2022

Splicing factor, arginine/serine-rich 16 is a protein that in humans is encoded by the SFRS16 gene.^[3]^[4]

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Splicing factor, arginine/serine-rich 4 is a protein that in humans is encoded by the SFRS4 gene.

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Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.

Putative splicing factor, arginine/serine-rich 14 is a protein that in humans is encoded by the SFRS14 gene.

Splicing factor, arginine/serine-rich 18 is a protein that in humans is encoded by the SFRS18 gene.

Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a protein that in humans is encoded by the SRSF1 gene. ASF/SF2 is an essential sequence specific splicing factor involved in pre-mRNA splicing. SRSF1 is the gene that codes for ASF/SF2 and is found on chromosome 17. The resulting splicing factor is a protein of approximately 33 kDa. ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing. In addition to being involved in the splicing process, ASF/SF2 also mediates post-splicing activities, such as mRNA nuclear export and translation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000104859 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Katsu R, Onogi H, Wada K, Kawaguchi Y, Hagiwara M (Nov 2002). "Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk". J Biol Chem. 277 (46): 44220–8. doi: 10.1074/jbc.M206504200 . PMID 12169693.
↑ "Entrez Gene: SFRS16 splicing factor, arginine/serine-rich 16".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
de Graaf K, Hekerman P, Spelten O, et al. (2004). "Characterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factors". J. Biol. Chem. 279 (6): 4612–24. doi: 10.1074/jbc.M310794200 . PMID 14623875.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000104859 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12169693-3] Katsu R, Onogi H, Wada K, Kawaguchi Y, Hagiwara M (Nov 2002). "Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk". J Biol Chem. 277 (46): 44220–8. doi: 10.1074/jbc.M206504200 . PMID 12169693.

[entrez-4] "Entrez Gene: SFRS16 splicing factor, arginine/serine-rich 16".

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[2]

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[4]

SFRS16

Related Research Articles

References

Further reading