SRGAP3

SRGAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AM4, 1GRN, 1OW3, 1RGP, 1TX4, 2NGR
Identifiers
Aliases	SRGAP3 , ARHGAP14, MEGAP, SRGAP2, WRP, SLIT-ROBO Rho GTPase activating protein 3
External IDs	OMIM: 606525; MGI: 2152938; HomoloGene: 56686; GeneCards: SRGAP3; OMA:SRGAP3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p25.3 Start 8,980,591 bp [1] End 9,363,053 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 E3 Start 112,694,932 bp [2] End 112,924,227 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 paraflocculus of cerebellum Brodmann area 10 frontal pole right uterine tube endothelial cell Region I of hippocampus proper Brodmann area 46 postcentral gyrus Top expressed in subiculum pontine nuclei superior colliculus cingulate gyrus piriform cortex dentate gyrus cerebellar vermis lateral septal nucleus hippocampus proper anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytoplasm cytosol Biological process negative regulation of cell migration regulation of small GTPase mediated signal transduction signal transduction positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9901 259302 Ensembl ENSG00000196220 ENSMUSG00000030257 UniProt O43295 Q812A2 RefSeq (mRNA) NM_001033116 NM_001033117 NM_014850 NM_080448 NM_153070 RefSeq (protein) NP_001028289 NP_055665 NP_536696 Location (UCSC) Chr 3: 8.98 – 9.36 Mb Chr 6: 112.69 – 112.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000196220 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030257 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, Maher ER, Tariverdian G, Kirsch S, Karch D, Rappold GA (Sep 2002). "The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation". Proc Natl Acad Sci U S A. 99 (18): 11754–9. Bibcode:2002PNAS...9911754E. doi: 10.1073/pnas.162241099 . PMC   129341 . PMID   12195014.
6. "Entrez Gene: SRGAP3 SLIT-ROBO Rho GTPase activating protein 3".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307 . PMID   9455477.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID   10574461.
• Wong K, Ren XR, Huang YZ, et al. (2001). "Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway". Cell. 107 (2): 209–21. doi: 10.1016/S0092-8674(01)00530-X . PMID   11672528. S2CID   2458943.
• Olave I, Wang W, Xue Y, et al. (2002). "Identification of a polymorphic, neuron-specific chromatin remodeling complex". Genes Dev. 16 (19): 2509–17. doi:10.1101/gad.992102. PMC   187451 . PMID   12368262.
• Soderling SH, Binns KL, Wayman GA, et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID   12447388. S2CID   1423222.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID   12736724.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Yang Y, Marcello M, Endris V, et al. (2006). "MEGAP impedes cell migration via regulating actin and microtubule dynamics and focal complex formation". Exp. Cell Res. 312 (12): 2379–93. doi:10.1016/j.yexcr.2006.04.001. PMID   16730001.