ST6GALNAC6

ST6GALNAC6
Identifiers
Aliases	ST6GALNAC6 , SIAT7-F, SIAT7F, ST6GALNACVI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
External IDs	OMIM: 610135; MGI: 1355316; HomoloGene: 8390; GeneCards: ST6GALNAC6; OMA:ST6GALNAC6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.11 Start 127,885,321 bp [1] End 127,905,408 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 B Start 32,489,721 bp [2] End 32,510,818 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amygdala nucleus accumbens putamen caudate nucleus anterior cingulate cortex right frontal lobe hippocampus proper rectum right coronary artery dorsolateral prefrontal cortex Top expressed in left colon superior frontal gyrus neural layer of retina dentate gyrus of hippocampal formation granule cell primary visual cortex cerebellar cortex muscle of thigh right ventricle olfactory tubercle ciliary body More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glycosyltransferase activity sialyltransferase activity alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Cellular component integral component of membrane Golgi apparatus membrane plasma membrane Golgi membrane cytoplasm Biological process cell-cell recognition glycoprotein metabolic process glycosphingolipid metabolic process protein glycosylation glycosylceramide metabolic process oligosaccharide metabolic process sialylation protein N-linked glycosylation via asparagine ganglioside biosynthetic process oligosaccharide biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30815 50935 Ensembl ENSG00000160408 ENSMUSG00000026811 UniProt Q969X2 Q9JM95 RefSeq (mRNA) NM_001286999 NM_001287000 NM_001287001 NM_001287002 NM_001287003 NM_013443 NM_001388489 NM_001025310 NM_001025311 NM_001289547 NM_001289548 NM_001289549 NM_016973 RefSeq (protein) NP_001273928 NP_001273929 NP_001273930 NP_001273931 NP_001273932 NP_038471 NP_001020481 NP_001020482 NP_001276476 NP_001276477 NP_001276478 NP_058669 Location (UCSC) Chr 9: 127.89 – 127.91 Mb Chr 2: 32.49 – 32.51 Mb PubMed search [3] [4]
Wikidata
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Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000160408 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026811 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi: 10.1074/jbc.M211034200 . PMID   12668675.
6. "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".

Further reading

• Senda M, Ito A, Tsuchida A, et al. (2007). "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers". Biochem. J. 402 (3): 459–70. doi:10.1042/BJ20061118. PMC   1863573 . PMID   17123352.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID   16713569. S2CID   13709685.
• Harduin-Lepers A, Mollicone R, Delannoy P, Oriol R (2005). "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach". Glycobiology. 15 (8): 805–17. doi: 10.1093/glycob/cwi063 . PMID   15843597.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Okajima T, Chen HH, Ito H, et al. (2000). "Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene". J. Biol. Chem. 275 (10): 6717–23. doi: 10.1074/jbc.275.10.6717 . PMID   10702226.