ST6GALNAC6

ST6GALNAC6
Identifiers
Aliases	ST6GALNAC6 , SIAT7-F, SIAT7F, ST6GALNACVI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
External IDs	OMIM: 610135 MGI: 1355316 HomoloGene: 8390 GeneCards: ST6GALNAC6
Gene location (Human)
Chr.	Chromosome 9 (human)
End	127,905,408 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,510,818 bp
RNA expression pattern
	Top expressed in
	amygdala; ; nucleus accumbens; ; putamen; ; caudate nucleus; ; hippocampus proper; ; rectum; ; right coronary artery; ; dorsolateral prefrontal cortex; ; popliteal artery; ; prefrontal cortex;
	Top expressed in
	left colon; ; superior frontal gyrus; ; cerebellar cortex; ; right ventricle; ; olfactory tubercle; ; ciliary body; ; piriform cortex; ; lateral hypothalamus; ; prefrontal cortex; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; glycosyltransferase activity ; sialyltransferase activity ; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ;
Cellular component	integral component of membrane ; Golgi apparatus ; membrane ; plasma membrane ; Golgi membrane ; cytoplasm ;
Biological process	cell-cell recognition ; glycoprotein metabolic process ; glycosphingolipid metabolic process ; protein glycosylation ; glycosylceramide metabolic process ; oligosaccharide metabolic process ; sialylation ; protein N-linked glycosylation via asparagine ; ganglioside biosynthetic process ; oligosaccharide biosynthetic process ;
	Sources:Amigo / QuickGO
Orthologs
	30815
	50935
	ENSG00000160408
	ENSMUSG00000026811
	Q969X2
	Q9JM95
NM_001286999 ; NM_001287000 ; NM_001287001 ; NM_001287002 ; NM_001287003 ;
	NM_013443 ; NM_001388489
NM_001025310 ; NM_001025311 ; NM_001289547 ; NM_001289548 ; NM_001289549 ;
	NM_016973
NP_001273928 ; NP_001273929 ; NP_001273930 ; NP_001273931 ; NP_001273932 ;
	NP_038471
NP_001020481 ; NP_001020482 ; NP_001276476 ; NP_001276477 ; NP_001276478 ;
	NP_058669
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.^[5]^[6]

Related Research Articles

<span class="mw-page-title-main">Sialyltransferase</span>

Sialyltransferases are enzymes that transfer sialic acid to nascent oligosaccharide. Each sialyltransferase is specific for a particular sugar substrate. Sialyltransferases add sialic acid to the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.

Beta-galactoside alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GAL1 gene.

Beta-1,4-galactosyltransferase 1 is an enzyme that in humans is encoded by the B4GALT1 gene.

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the GCNT1 gene.

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA4 gene.

Lactosylceramide alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL5 gene.

Polypeptide N-acetylgalactosaminyltransferase 2 is an enzyme that in humans is encoded by the GALNT2 gene.

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.

UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B3GALNT1 gene.

ST3 beta-galactoside alpha-2,3-sialyltransferase 3, also known as ST3GAL3, is a protein which in humans is encoded by the ST3GAL3 gene.

Beta-1,4-galactosyltransferase 7 also known as galactosyltransferase I is an enzyme that in humans is encoded by the B4GALT7 gene. Galactosyltransferase I catalyzes the synthesis of the glycosaminoglycan-protein linkage in proteoglycans. Proteoglycans in turn are structural components of the extracellular matrix that is found between cells in connective tissues.

Beta-1,4 N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B4GALNT1 gene.

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, also known as sialyltransferase 3C (SIAT3-C) or sialyltransferase 7D (SIAT7-D) is a sialyltransferase enzyme that in humans is encoded by the ST6GALNAC4 gene.

Beta-1,4-galactosyltransferase 2 is an enzyme that in humans is encoded by the B4GALT2 gene.

Beta-1,4-galactosyltransferase 5 is an enzyme that in humans is encoded by the B4GALT5 gene.

Polypeptide N-acetylgalactosaminyltransferase 6 is an enzyme that in humans is encoded by the GALNT6 gene.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene. This enzyme adds a N-Acetylneuraminic acid to an O-linked N-Acetylgalactosamine (GalNAc) on a peptide/proteins with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers Thr over Ser containing GalNAc residues.

Beta-1,4-galactosyltransferase 4 is an enzyme that in humans is encoded by the B4GALT4 gene.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 is an enzyme that in humans is encoded by the ST6GALNAC2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160408 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026811 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi: 10.1074/jbc.M211034200 . PMID 12668675.
↑ "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".

Senda M, Ito A, Tsuchida A, et al. (2007). "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers". Biochem. J. 402 (3): 459–70. doi:10.1042/BJ20061118. PMC 1863573 . PMID 17123352.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi: 10.1016/j.cell.2006.03.032 . PMID 16713569. S2CID 13709685.
Harduin-Lepers A, Mollicone R, Delannoy P, Oriol R (2005). "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach". Glycobiology. 15 (8): 805–17. doi: 10.1093/glycob/cwi063 . PMID 15843597.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Okajima T, Chen HH, Ito H, et al. (2000). "Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene". J. Biol. Chem. 275 (10): 6717–23. doi: 10.1074/jbc.275.10.6717 . PMID 10702226.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160408 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026811 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12668675-5] Tsuchida A, Okajima T, Furukawa K, Ando T, Ishida H, Yoshida A, Nakamura Y, Kannagi R, Kiso M, Furukawa K (Jun 2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides". J Biol Chem. 278 (25): 22787–94. doi: 10.1074/jbc.M211034200 . PMID 12668675.

[entrez-6] "Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6".

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ST6GALNAC6

Related Research Articles

References

Further reading