ST8SIA1

ST8SIA1
Identifiers
Aliases	ST8SIA1 , GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
External IDs	OMIM: 601123 MGI: 106011 HomoloGene: 2282 GeneCards: ST8SIA1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	22,437,041 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	142,910,178 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; prefrontal cortex; ; cingulate gyrus; ; hypothalamus; ; amygdala; ; dorsolateral prefrontal cortex; ; lymph node; ; Brodmann area 9; ; canal of the cervix;
	Top expressed in
	molar; ; facial motor nucleus; ; medial vestibular nucleus; ; anterior horn of spinal cord; ; pontine nuclei; ; dorsal tegmental nucleus; ; substantia nigra; ; proximal tubule; ; habenula; ; lateral geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; sialyltransferase activity ; glycosyltransferase activity ; alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity ;
Cellular component	integral component of membrane ; Golgi membrane ; Golgi apparatus ; membrane ;
Biological process	glycosphingolipid biosynthetic process ; sialylation ; protein glycosylation ; cellular response to heat ; positive regulation of cell population proliferation ; sphingolipid metabolic process ; lipid metabolism ; carbohydrate metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	6489
	20449
	ENSG00000111728
	ENSMUSG00000030283
	Q92185
	Q64687
	NM_001304450 ; NM_003034
	NM_011374
	NP_001291379 ; NP_003025
	NP_035504
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2024

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.^[5]^[6]

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by ST8SIA1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.^[6]

In melanocytic cells, ST8SIA1 gene expression may be regulated by MITF.^[7]

Related Research Articles

A ganglioside is a molecule composed of a glycosphingolipid with one or more sialic acids linked on the sugar chain. NeuNAc, an acetylated derivative of the carbohydrate sialic acid, makes the head groups of gangliosides anionic at pH 7, which distinguishes them from globosides.

<span class="mw-page-title-main">Sialyltransferase</span> Class of enzymes

Sialyltransferases are enzymes that transfer sialic acid to nascent oligosaccharide. Each sialyltransferase is specific for a particular sugar substrate. Sialyltransferases add sialic acid to the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.

GM2 ganglioside activator also known as GM2A is a protein which in humans is encoded by the GM2A gene.

Beta-galactoside alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GAL1 gene.

In enzymology, an alpha-N-acetylneuraminate alpha-2,8-sialyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, a lactosylceramide alpha-2,3-sialyltransferase is an enzyme that catalyzes the chemical reaction

Sialic acid-binding Ig-like lectin 7 is a protein that in humans is encoded by the SIGLEC7 gene. SIGLEC7 has also been designated as CD328.

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA4 gene.

Lactosylceramide alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL5 gene.

Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene.

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.

Alpha-2,8-sialyltransferase 8B is an enzyme that in humans is encoded by the ST8SIA2 gene.

ST3 beta-galactoside alpha-2,3-sialyltransferase 3, also known as ST3GAL3, is a protein which in humans is encoded by the ST3GAL3 gene.

Beta-1,4 N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the B4GALNT1 gene.

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4, also known as sialyltransferase 3C (SIAT3-C) or sialyltransferase 7D (SIAT7-D) is a sialyltransferase enzyme that in humans is encoded by the ST6GALNAC4 gene.

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.

Sialic acid synthase is an enzyme that in humans is encoded by the NANS gene.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.

(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase is an enzyme with systematic name UDP-N-acetyl-D-galactosamine:1-O-(O- - -O-beta-D-galactopyranosyl- -beta-D-glucopyranosyl)-ceramide 4-beta-N-acetyl-D-galactosaminyltransferase. This enzyme catalyses the following chemical reaction:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111728 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030283 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sasaki K, Watanabe E, Kawashima K, Sekine S, Dohi T, Oshima M, Hanai N, Nishi T, Hasegawa M (Dec 1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection". J Biol Chem. 268 (30): 22782–7. doi: 10.1016/S0021-9258(18)41595-5 . PMID 7901202.
1 2 "Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1".
↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID 19067971. S2CID 24698373.

Haraguchi M, Yamashiro S, Yamamoto A, et al. (1994). "Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10455–9. Bibcode:1994PNAS...9110455H. doi: 10.1073/pnas.91.22.10455 . PMC 45039 . PMID 7937974.
Nara K, Watanabe Y, Maruyama K, et al. (1994). "Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells". Proc. Natl. Acad. Sci. U.S.A. 91 (17): 7952–6. Bibcode:1994PNAS...91.7952N. doi: 10.1073/pnas.91.17.7952 . PMC 44522 . PMID 8058740.
Sasaki K, Kurata K, Kojima N, et al. (1994). "Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase)". J. Biol. Chem. 269 (22): 15950–6. doi: 10.1016/S0021-9258(17)40773-3 . PMID 8195250.
Nakayama J, Fukuda MN, Hirabayashi Y, et al. (1996). "Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme". J. Biol. Chem. 271 (7): 3684–91. doi: 10.1074/jbc.271.7.3684 . PMID 8631981.
Matsuda Y, Nara K, Watanabe Y, et al. (1996). "Chromosome mapping of the GD3 synthase gene (SIAT8) in human and mouse". Genomics. 32 (1): 137–9. doi:10.1006/geno.1996.0090. PMID 8786103.
De Maria R, Lenti L, Malisan F, et al. (1997). "Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis". Science. 277 (5332): 1652–5. doi:10.1126/science.277.5332.1652. hdl:11566/37451. PMID 9287216.
Angata K, Suzuki M, McAuliffe J, et al. (2000). "Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III". J. Biol. Chem. 275 (24): 18594–601. doi: 10.1074/jbc.M910204199 . PMID 10766765.
Zeng G, Gao L, Suetake K, et al. (2002). "Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed". Cancer Lett. 178 (1): 91–8. doi:10.1016/S0304-3835(01)00817-5. PMID 11849746.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Furukawa K, Horie M, Okutomi K, et al. (2003). "Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene". Biochim. Biophys. Acta. 1627 (2–3): 71–8. doi:10.1016/s0167-4781(03)00076-9. PMID 12818424.
Moon SK, Kim HM, Lee YC, Kim CH (2004). "Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression". J. Biol. Chem. 279 (32): 33063–70. doi: 10.1074/jbc.M313462200 . PMID 15175338.
Ha KT, Lee YC, Kim CH (2004). "Overexpression of GD3 synthase induces apoptosis of vascular endothelial ECV304 cells through downregulation of Bcl-2". FEBS Lett. 568 (1–3): 183–7. doi: 10.1016/j.febslet.2004.05.020 . PMID 15196944. S2CID 34782656.
Tomassini B, Malisan F, Franchi L, et al. (2005). "Calnexin suppresses GD3 synthase-induced apoptosis". FASEB J. 18 (13): 1553–5. doi: 10.1096/fj.04-1675fje . PMID 15319364. S2CID 44936219.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Teintenier-Lelièvre M, Julien S, Juliant S, et al. (2006). "Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins". Biochem. J. 392 (Pt 3): 665–74. doi:10.1042/BJ20051120. PMC 1316308 . PMID 16120058.
Kang NY, Kang Y, Kang SK, et al. (2006). "Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-kappaB in regulated expression". Glycobiology. 16 (5): 375–89. doi:10.1093/glycob/cwj087. PMID 16481330.
Ko K, Furukawa K, Takahashi T, et al. (2006). "Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers". Oncogene. 25 (52): 6924–35. doi:10.1038/sj.onc.1209683. PMID 16862187. S2CID 30102036.
Szabo R, Skropeta D, et al. (2017). "Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities". Med. Res. Rev. 37 (2): 210–270. doi:10.1002/med.21407. PMID 27678392. S2CID 26280291.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111728 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030283 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7901202-5] Sasaki K, Watanabe E, Kawashima K, Sekine S, Dohi T, Oshima M, Hanai N, Nishi T, Hasegawa M (Dec 1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection". J Biol Chem. 268 (30): 22782–7. doi: 10.1016/S0021-9258(18)41595-5 . PMID 7901202.

[entrez-6] 1 2 "Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi: 10.1111/j.1755-148X.2008.00505.x . PMID 19067971. S2CID 24698373.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

ST8SIA1

Related Research Articles

References

Further reading