STK39

STK39
Identifiers
Aliases	STK39 , DCHT, PASK, SPAK, serine/threonine kinase 39
External IDs	OMIM: 607648 MGI: 1858416 HomoloGene: 22739 GeneCards: STK39
Gene location (Human)
Chr.	Chromosome 2 (human)
End	168,247,595 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	68,302,612 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; pons; ; parotid gland; ; palpebral conjunctiva; ; inferior ganglion of vagus nerve; ; tibia; ; subthalamic nucleus; ; superior vestibular nucleus; ; corpus callosum; ; Brodmann area 23;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; salivary gland; ; submandibular gland; ; lacrimal gland; ; parotid gland; ; atrium; ; facial motor nucleus; ; anterior horn of spinal cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein kinase activity ; protein binding ; ATP binding ; protein serine/threonine kinase activity ; kinase activity ; protein kinase binding ;
Cellular component	membrane ; basolateral plasma membrane ; apical plasma membrane ; cytoskeleton ; nucleoplasm ; extrinsic component of membrane ; intracellular membrane-bounded organelle ; nucleus ; cytoplasm ; cytosol ;
Biological process	negative regulation of protein phosphorylation ; intracellular signal transduction ; signal transduction ; phosphorylation ; positive regulation of potassium ion transport ; cellular hypotonic response ; regulation of blood pressure ; negative regulation of potassium ion transmembrane transporter activity ; regulation of inflammatory response ; negative regulation of potassium ion transmembrane transport ; negative regulation of pancreatic juice secretion ; peptidyl-threonine phosphorylation ; positive regulation of ion transmembrane transporter activity ; maintenance of lens transparency ; negative regulation of creatine transmembrane transporter activity ; negative regulation of sodium ion transmembrane transporter activity ; regulation of mitotic cell cycle ; stress-activated protein kinase signaling cascade ; activation of protein kinase activity ; regulation of apoptotic process ; protein phosphorylation ; peptidyl-serine phosphorylation ; protein autophosphorylation ; ion homeostasis ; positive regulation of T cell chemotaxis ; chemokine (C-X-C motif) ligand 12 signaling pathway ; cellular response to chemokine ;
	Sources:Amigo / QuickGO
Orthologs
	27347
	53416
	ENSG00000198648
	ENSMUSG00000027030
	Q9UEW8
	Q9Z1W9
	NM_013233
	NM_016866
	NP_037365
	NP_058562
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.^[5]^[6]

This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.^[6] Some studies suggest that this gene might be linked to high blood pressure.^[7]

Related Research Articles

The sodium-chloride symporter (also known as Na⁺-Cl⁻ cotransporter, NCC or NCCT, or as the thiazide-sensitive Na⁺-Cl⁻ cotransporter or TSC) is a cotransporter in the kidney which has the function of reabsorbing sodium and chloride ions from the tubular fluid into the cells of the distal convoluted tubule of the nephron. It is a member of the SLC12 cotransporter family of electroneutral cation-coupled chloride cotransporters. In humans, it is encoded by the SLC12A3 gene (solute carrier family 12 member 3) located in 16q13.

Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene.

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

Serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the STK4 gene.

Serine/threonine-protein kinase N1 is an enzyme that in humans is encoded by the PKN1 gene.

5'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene. This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.

Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene.

WNK , also known as WNK1, is an enzyme that is encoded by the WNK1 gene. WNK1 is serine-threonine protein kinase and part of the "with no lysine/K" kinase WNK family. The predominant role of WNK1 is the regulation of cation-Cl⁻ cotransporters (CCCs) such as the sodium chloride cotransporter (NCC), basolateral Na-K-Cl symporter (NKCC1), and potassium chloride cotransporter (KCC1) located within the kidney. CCCs mediate ion homeostasis and modulate blood pressure by transporting ions in and out of the cell. WNK1 mutations as a result have been implicated in blood pressure disorders/diseases; a prime example being familial hyperkalemic hypertension (FHHt).

Ribosomal protein S6 kinase beta-2 is an enzyme that in humans is encoded by the RPS6KB2 gene.

Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the OXSR1 gene.

Serine/threonine-protein kinase TAO1 is an enzyme that in humans is encoded by the TAOK1 gene.

Serine/threonine protein kinase WNK4 also known as WNK lysine deficient protein kinase 4 or WNK4, is an enzyme that in humans is encoded by the WNK4 gene. Missense mutations cause a genetic form of pseudohypoaldosteronism type 2, also called Gordon syndrome.

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.

Potassium-chloride transporter member 5 is a neuron-specific chloride potassium symporter responsible for establishing the chloride ion gradient in neurons through the maintenance of low intracellular chloride concentrations. It is a critical mediator of synaptic inhibition, cellular protection against excitotoxicity and may also act as a modulator of neuroplasticity. Potassium-chloride transporter member 5 is also known by the names: KCC2 for its ionic substrates, and SLC12A5 for its genetic origin from the SLC12A5 gene in humans.

MAP kinase-activated protein kinase 5 is an enzyme that in humans is encoded by the MAPKAPK5 gene. The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases, including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately-spliced transcript variants of this gene encoding distinct isoforms have been reported.

Calcium/calmodulin-dependent protein kinase kinase 1 is an enzyme that in humans is encoded by the CAMKK1 gene.

Serine/threonine-protein kinase 24 is an enzyme that in humans is encoded by the STK24 gene located in the chromosome 13, band q32.2. It is also known as Mammalian STE20-like protein kinase 3 (MST-3). The protein is 443 amino acids long and its mass is 49 kDa.

Calcium-binding protein 39 is a protein that in humans is encoded by the CAB39 gene.

Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198648 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027030 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Johnston AM, Naselli G, Gonez LJ, Martin RM, Harrison LC, DeAizpurua HJ (Oct 2000). "SPAK, a STE20/SPS1-related kinase that activates the p38 pathway". Oncogene. 19 (37): 4290–7. doi: 10.1038/sj.onc.1203784 . PMID 10980603.
1 2 "Entrez Gene: STK39 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)".
↑ "Reuters: Key gene linked to high blood pressure identified". 29 December 2008.

Qi H, Labrie Y, Grenier J, et al. (2001). "Androgens induce expression of SPAK, an STE20/SPS1-related kinase, in LNCaP human prostate cancer cells". Mol. Cell. Endocrinol. 182 (2): 181–92. doi:10.1016/S0303-7207(01)00560-3. PMID 11514053. S2CID 26078681.
Dowd BF, Forbush B (2003). "PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1)". J. Biol. Chem. 278 (30): 27347–53. doi: 10.1074/jbc.M301899200 . PMID 12740379.
Piechotta K, Garbarini N, England R, Delpire E (2004). "Characterization of the interaction of the stress kinase SPAK with the Na⁺-K⁺-2Cl⁻ cotransporter in the nervous system: evidence for a scaffolding role of the kinase". J. Biol. Chem. 278 (52): 52848–56. doi: 10.1074/jbc.M309436200 . PMID 14563843.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Moriguchi T, Urushiyama S, Hisamoto N, et al. (2006). "WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1". J. Biol. Chem. 280 (52): 42685–93. doi: 10.1074/jbc.M510042200 . PMID 16263722.
Vitari AC, Thastrup J, Rafiqi FH, et al. (2006). "Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1". Biochem. J. 397 (1): 223–31. doi:10.1042/BJ20060220. PMC 1479760 . PMID 16669787.
Polek TC, Talpaz M, Spivak-Kroizman TR (2006). "TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis". Biochem. Biophys. Res. Commun. 349 (3): 1016–24. doi:10.1016/j.bbrc.2006.08.118. PMID 16950202.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Yan Y, Nguyen H, Dalmasso G, et al. (2007). "Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform". Biochim. Biophys. Acta. 1769 (2): 106–16. doi:10.1016/j.bbaexp.2007.01.003. PMC 1865517 . PMID 17321610.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198648 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027030 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10980603-5] Johnston AM, Naselli G, Gonez LJ, Martin RM, Harrison LC, DeAizpurua HJ (Oct 2000). "SPAK, a STE20/SPS1-related kinase that activates the p38 pathway". Oncogene. 19 (37): 4290–7. doi: 10.1038/sj.onc.1203784 . PMID 10980603.

[entrez-6] 1 2 "Entrez Gene: STK39 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)".

[re-stk39-7] "Reuters: Key gene linked to high blood pressure identified". 29 December 2008.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

STK39

Related Research Articles

References

Further reading