SULT4A1

SULT4A1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZD1
Identifiers
Aliases	SULT4A1 , BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1, sulfotransferase family 4A member 1
External IDs	OMIM: 608359 MGI: 1888971 HomoloGene: 49378 GeneCards: SULT4A1
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q13.31 Start 43,824,509 bp [1] End 43,862,513 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 E2 Start 83,960,298 bp [2] End 83,989,955 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex Brodmann area 9 middle temporal gyrus Brodmann area 10 cingulate gyrus frontal pole Brodmann area 23 orbitofrontal cortex Brodmann area 46 superior frontal gyrus Top expressed in medial dorsal nucleus medial vestibular nucleus superior frontal gyrus medial geniculate nucleus lateral geniculate nucleus pontine nuclei primary motor cortex lateral hypothalamus globus pallidus mammillary body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity sulfotransferase activity protein binding aryl sulfotransferase activity identical protein binding Cellular component cytoplasm cytosol Biological process sulfur compound metabolic process steroid metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process lipid metabolism biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25830 29859 Ensembl ENSG00000130540 ENSMUSG00000018865 UniProt Q9BR01 P63046 RefSeq (mRNA) NM_014351 NM_176874 NM_013873 NM_001356515 RefSeq (protein) NP_055166 NP_038901 NP_001343444 Location (UCSC) Chr 22: 43.82 – 43.86 Mb Chr 15: 83.96 – 83.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene. ^{[5] [6]}

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000130540 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000018865 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Falany CN, Xie X, Wang J, Ferrer J, Falany JL (May 2000). "Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain". Biochem J. 346. Pt 3 (3): 857–64. doi:10.1042/bj3460857. PMC   1220923 . PMID   10698717.
6. "Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1".

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes". FASEB J. 11 (1): 3–14. doi: 10.1096/fasebj.11.1.9034160 . PMID   9034160. S2CID   3977677.
• Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology". Toxicol. Lett. 112–113 (1–3): 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID   10720750.
• Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics". Chem. Biol. Interact. 129 (1–2): 141–70. Bibcode:2000CBI...129..141G. doi:10.1016/S0009-2797(00)00202-7. PMID   11154739.
• Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects". Mutat. Res. 482 (1–2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID   11535246.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi: 10.1038/990031 . PMID   10591208.
• Sakakibara Y, Suiko M, Pai TG, et al. (2002). "Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization". Gene. 285 (1–2): 39–47. doi:10.1016/S0378-1119(02)00431-6. PMID   12039030.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC   430954 . PMID   12529303.
• Liyou NE, Buller KM, Tresillian MJ, et al. (2004). "Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study". J. Histochem. Cytochem. 51 (12): 1655–64. doi: 10.1177/002215540305101209 . PMID   14623933.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi: 10.1186/gb-2004-5-10-r84 . PMC   545604 . PMID   15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Brennan MD, Condra J (2006). "Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 139 (1): 69–72. doi:10.1002/ajmg.b.30222. PMID   16152568. S2CID   8927459.
• Allali-Hassani A, Pan PW, Dombrovski L, et al. (2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLOS Biol. 5 (5): e97. doi: 10.1371/journal.pbio.0050097 . PMC   1847840 . PMID   17425406.