SYBU

SYBU
Identifiers
Aliases	SYBU , GOLSYN, OCSYN, SNPHL, syntabulin
External IDs	OMIM: 611568 MGI: 2442392 HomoloGene: 9838 GeneCards: SYBU
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q23.2 Start 109,573,978 bp [1] End 109,691,791 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 B3.2 Start 44,535,252 bp [2] End 44,651,459 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis middle temporal gyrus superior frontal gyrus postcentral gyrus Brodmann area 23 body of pancreas entorhinal cortex cerebellar hemisphere orbitofrontal cortex pons Top expressed in cerebellar vermis ventromedial nucleus piriform cortex dentate gyrus habenula paraventricular nucleus of hypothalamus mammillary body dorsomedial hypothalamic nucleus lateral hypothalamus dermal bone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding protein binding syntaxin-1 binding kinesin binding Cellular component cytoplasm cytoplasmic vesicle integral component of membrane Golgi membrane Golgi apparatus dense body intracellular membrane-bounded organelle cytoskeleton membrane microtubule vesicle axon cytoplasm Biological process regulation of insulin secretion involved in cellular response to glucose stimulus axonal transport of mitochondrion positive regulation of insulin secretion involved in cellular response to glucose stimulus regulation of synaptic activity synapse maturation anterograde neuronal dense core vesicle transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55638 319613 Ensembl ENSG00000147642 ENSMUSG00000022340 UniProt Q9NX95 Q8BHS8 RefSeq (mRNA) NM_001099743 NM_001099744 NM_001099745 NM_001099746 NM_001099747 NM_001099748 NM_001099749 NM_001099750 NM_001099751 NM_001099752 NM_001099753 NM_001099754 NM_001099755 NM_001099756 NM_017786 NM_001330596 NM_001363032 NM_001032727 NM_001285840 NM_001285841 NM_001285842 NM_001285843 NM_001285844 NM_176998 NM_178765 NM_001358582 NM_001358583 NM_001358584 RefSeq (protein) NP_001093213 NP_001093214 NP_001093215 NP_001093216 NP_001093217 NP_001093218 NP_001093219 NP_001093220 NP_001093221 NP_001093222 NP_001093223 NP_001093224 NP_001093225 NP_001093226 NP_001317525 NP_060256 NP_001349961 NP_001027899 NP_001272769 NP_001272770 NP_001272771 NP_001272772 NP_001272773 NP_795972 NP_848880 NP_001345511 NP_001345512 NP_001345513 Location (UCSC) Chr 8: 109.57 – 109.69 Mb Chr 15: 44.54 – 44.65 Mb PubMed search [3] [4]
Wikidata
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Syntabulin, also known as SYBU, is a human gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000147642 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022340 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FLJ20366 hypothetical protein FLJ20366".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID   10819331.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID   12107410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Su Q, Cai Q, Gerwin C, et al. (2004). "Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons". Nat. Cell Biol. 6 (10): 941–53. doi:10.1038/ncb1169. PMID   15459722. S2CID   6875457.
• Funakoshi E, Nakagawa KY, Hamano A, et al. (2005). "Molecular cloning and characterization of gene for Golgi-localized syntaphilin-related protein on human chromosome 8q23". Gene. 344: 259–71. doi:10.1016/j.gene.2004.10.024. PMID   15656992.
• Cai Q, Gerwin C, Sheng ZH (2005). "Syntabulin-mediated anterograde transport of mitochondria along neuronal processes". J. Cell Biol. 170 (6): 959–69. doi:10.1083/jcb.200506042. PMC   1804288 . PMID   16157705.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Funakoshi E, Fukui M, Hamano A, et al. (2006). "Expression of m-Golsyn/Syntabulin gene during mouse brain development". Neurosci. Lett. 403 (3): 244–9. doi:10.1016/j.neulet.2006.04.061. PMID   16750881. S2CID   40236853.
• Cai Q, Pan PY, Sheng ZH (2007). "Syntabulin-kinesin-1 family member 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly". J. Neurosci. 27 (27): 7284–96. doi: 10.1523/JNEUROSCI.0731-07.2007 . PMC   6794594 . PMID   17611281.