SYTL2

Last updated
SYTL2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SYTL2 , CHR11SYT, EXO4, PPP1R151, SGA72M, SLP2, SLP2A, synaptotagmin like 2
External IDs OMIM: 612880 MGI: 1933366 HomoloGene: 131343 GeneCards: SYTL2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 11: 85.69 – 85.81 Mb Chr 7: 89.95 – 90.06 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Synaptotagmin-like 2, also known as SYTL2, is a human gene. [5]

Function

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A), which suggests a role in vesicle trafficking. Multiple alternatively spiced transcript variants encoding distinct isoforms have been observed. [5]

Interactions

SYTL2 has been shown to interact with RAB27A. [6] [7] [8]

Related Research Articles

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<span class="mw-page-title-main">SYNCRIP</span> Protein-coding gene in the species Homo sapiens

Synaptotagmin-binding, cytoplasmic RNA-interacting protein (SYNCRIP), also known as heterogeneous nuclear ribonucleoprotein (hnRNP) Q or NS1-associated protein-1 (NSAP-1), is a protein that in humans is encoded by the SYNCRIP gene. As the name implies, SYNCRIP is localized predominantly in the cytoplasm. It is evolutionarily conserved across eukaryotes and participates in several cellular and disease pathways, especially in neuronal and muscular development. In humans, there are three isoforms, all of which are associated in vitro with pre-mRNAs, mRNA splicing intermediates, and mature mRNA-protein complexes, including mRNA turnover.

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<span class="mw-page-title-main">SYTL4</span> Protein-coding gene in the species Homo sapiens

Synaptotagmin-like protein 4 is a protein that in humans is encoded by the SYTL4 gene.

<span class="mw-page-title-main">SYT2</span> Protein-coding gene in the species Homo sapiens

Synaptotagmin-2 is a protein that in humans is encoded by the SYT2 gene.

<span class="mw-page-title-main">SYT3</span> Protein-coding gene in the species Homo sapiens

Synaptotagmin-3 is a protein that in humans is encoded by the SYT3 gene.

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<span class="mw-page-title-main">SYT11</span> Protein-coding gene in the species Homo sapiens

Synaptotagmin-11 is a protein that in humans is encoded by the SYT11 gene.

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Synaptotagmin-5 is a protein that in humans is encoded by the SYT5 gene.

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Synaptotagmin-like protein 1 is a protein that in humans is encoded by the SYTL1 gene.

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<span class="mw-page-title-main">SYT4</span> Protein-coding gene in the species Homo sapiens

Synaptotagmin-4 is a protein that in humans is encoded by the SYT4 gene.

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Synaptotagmin-7 is a protein that in humans is encoded by the SYT7 gene.

<span class="mw-page-title-main">RAB27A</span> Protein-coding gene in the species Homo sapiens

Ras-related protein Rab-27A is a protein that in humans is encoded by the RAB27A gene.

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Exophilin 5, also known as EXPH5, is a human gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137501 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030616 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: SYTL2 synaptotagmin-like 2".
  6. Fukuda M (April 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". The Journal of Biological Chemistry. 278 (17): 15390–6. doi: 10.1074/jbc.M213090200 . PMID   12590134.
  7. Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". The Journal of Biological Chemistry. 277 (28): 25423–30. doi: 10.1074/jbc.M202574200 . PMID   11980908.
  8. Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (March 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". The Journal of Biological Chemistry. 277 (11): 9212–8. doi: 10.1074/jbc.M112414200 . PMID   11773082.

Further reading