 |
Samuel Krimm | |
|---|---|
| Born | October 19, 1925 [1] |
| Alma mater |
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| Awards |
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| Scientific career | |
| Fields | Biophysics |
| Institutions | University of Michigan |
| Doctoral students | Willie Hobbs Moore [2] |
Samuel Krimm (born October 19, 1925) is an American physicist with a research focus in biophysics (spectroscopy, macromolecules, protein folding). He is professor emeritus and research scientist emeritus at University of Michigan. [3] [4]
Krimm earned a BS in chemistry, from Polytechnic Institute of Brooklyn (1947), and MS and PhD in physical chemistry from Princeton University (1949, 1950). [5]
Krimm was elected fellow of the American Physical Society in 1959. [6]
In 1977, Krimm received the American Physical Society's Polymer Physics Prize "For his outstanding experimental studies and theoretical developments in infrared and Ra-man spectroscopy and X-ray scattering from natural and synthetic polymers". [6]
In 1983, he was awarded the Humboldt Prize. [7]
From 1967-1972 he was doctoral advisor for Willie Hobbs Moore, who earned the first PhD in physics for an African-American woman at an American university. [2]
He was the first Director of the University of Michigan Program in Protein Structure and Design, created in 1985. [8]
He has published over 300 peer-reviewed articles, on the infrared and Raman spectroscopy of synthetic polymers and proteins, and in the field of theoretical and computational studies of the structures of such macromolecules. [9]
In his most recent work, he and colleague/collaborator Noemi Mirkin have proposed a new paradigm in the field of protein folding they term "milieu folding" demonstrating that the presence of particular molecules in the surrounding aqueous environment of a protein molecule ("milieu") can alter the propensities for the folded structure of the protein. They suggest that this is a more appropriate framework than "misfolding" to explore and understand protein-folding diseases. [10] [11]
Structural biology, as defined by the Journal of Structural Biology, deals with structural analysis of living material at every level of organization.
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Martin Karplus is an Austrian and American theoretical chemist. He is the Director of the Biophysical Chemistry Laboratory, a joint laboratory between the French National Center for Scientific Research and the University of Strasbourg, France. He is also the Theodore William Richards Professor of Chemistry, emeritus at Harvard University. Karplus received the 2013 Nobel Prize in Chemistry, together with Michael Levitt and Arieh Warshel, for "the development of multiscale models for complex chemical systems".
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The following outline is provided as an overview of and topical guide to biophysics:
Martin Gruebele is a German-born American physical chemist and biophysicist who is currently emeritus James R. Eiszner Chair in Chemistry, Professor of Physics, Professor of Biophysics and Computational Biology at the University of Illinois Urbana-Champaign.
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Joachim Heinrich Seelig was a German physical chemist and specialist in NMR Spectroscopy. He was one of the founding fathers of the Biozentrum of the University of Basel. He reached emeritus status in 2012.
Duncan G. Steel is an American experimental physicist, researcher and professor in quantum optics in condensed matter physics. He is the Robert J. Hiller Professor of Electrical Engineering, Professor of Physics, Professor of Biophysics, and Research Professor in the Institute of Gerontology at the University of Michigan. Steel is also a Guggenheim Scholar and a Fellow of American Physical Society, the Optical Society of America, and the Institute of Electrical and Electronics Engineers. He coedited the five-volume series on the Encyclopedia of Modern Optics.
Sheena Elizabeth Radford FRS FMedSci is a British biophysicist, and Astbury Professor of Biophysics in the Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology at the University of Leeds. Radford is the Associate Editor of the Journal of Molecular Biology.
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G. Marius Clore MAE, FRSC, FMedSci, FRS is a British-born, Anglo-American molecular biophysicist and structural biologist. He was born in London, U.K. and is a dual U.S./U.K. Citizen. He is a Member of the National Academy of Sciences, a Fellow of the Royal Society, a Fellow of the Academy of Medical Sciences, a Fellow of the American Academy of Arts and Sciences, a NIH Distinguished Investigator, and the Chief of the Molecular and Structural Biophysics Section in the Laboratory of Chemical Physics of the National Institute of Diabetes and Digestive and Kidney Diseases at the U.S. National Institutes of Health. He is known for his foundational work in three-dimensional protein and nucleic acid structure determination by biomolecular NMR spectroscopy, for advancing experimental approaches to the study of large macromolecules and their complexes by NMR, and for developing NMR-based methods to study rare conformational states in protein-nucleic acid and protein-protein recognition. Clore's discovery of previously undetectable, functionally significant, rare transient states of macromolecules has yielded fundamental new insights into the mechanisms of important biological processes, and in particular the significance of weak interactions and the mechanisms whereby the opposing constraints of speed and specificity are optimized. Further, Clore's work opens up a new era of pharmacology and drug design as it is now possible to target structures and conformations that have been heretofore unseen.
William Allen Eaton is a biophysical chemist who is a NIH Distinguished Investigator, Chief of the Section on Biophysical Chemistry, and Chief of the Laboratory of Chemical Physics at the National Institute of Diabetes and Digestive and Kidney Diseases, one of the 20 Institutes of the United States National Institutes of Health.
Karl Frederick Freed is an American theoretical chemist recognized for his research in polymer physics. Freed has spent his academic career in the department of chemistry and the James Frank Institute at the University of Chicago, where he is the Henry G. Gale Distinguished Service Professor emeritus. He is a member of the American Academy of Arts and Sciences, a Fellow of the American Physical Society, and was awarded the Polymer Physics Prize of the American Physical Society in 2014 and the Award in Pure Chemistry by the American Chemical Society in 1976.
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