Sara Imari Walker

Last updated
Sara Walker
NationalityAmerican
Alma mater Dartmouth College
Florida Institute of Technology
Cape Cod Community College
Scientific career
FieldsPhysics of life, astrobiology, abiogenesis
Institutions Georgia Institute of Technology
NASA Astrobiology Institute
Santa Fe Institute
Arizona State University
Thesis Theoretical Models for the Emergence of Biomolecular Homochirality
Doctoral advisor Marcelo Gleiser
Other academic advisors Paul Davies
Website http://emergence.asu.edu/

Sara Imari Walker is an American theoretical physicist and astrobiologist with research interests in the origins of life, astrobiology, physics of life, emergence, complex and dynamical systems, and artificial life. [1] [2] Walker is deputy director of the Beyond Center for Fundamental Concepts in Science at Arizona State University (ASU), associate director of the ASU-SFI Center for Biosocial Complex Systems and an associate professor at ASU. [3] [4] She is a co-founder of the astrobiology social network SAGANet, and on the board of directors for Blue Marble Space, a nonprofit education and science organization. [1] As a science communicator, she is a frequent guest on podcasts and series, such as Through the Wormhole with Morgan Freeman. [5]

Contents

Education and background

Walker was born and raised in Connecticut. She attended Cape Cod Community College and studied at the Florida Institute of Technology, where she graduated cum laude earning a B.S. in physics in 2005. She earned her Ph.D. in physics and astronomy in 2010 from Dartmouth College. [4] Her thesis was Theoretical Models for the Emergence of Biomolecular Homochirality and her doctoral advisor was Marcelo Gleiser. [6]

Career

After graduating from Dartmouth, Walker began a postdoctoral fellowship at the Georgia Institute of Technology working at the NSF/NASA Center for Chemical Evolution. [4] In 2011 she accepted a NASA Postdoctoral Program Fellowship with the NASA Astrobiology Institute and began working at Arizona State University (ASU). In 2013, Walker became an assistant professor at the School of Earth and Space Exploration as well as the Beyond Center for Fundamental Concepts in Science at ASU. [1] [7] She became a faculty member for the Center for Social Dynamics and Complexity, as well as a graduate faculty member for the Department of Physics and Complex Systems Initiative at ASU in 2014. [3] In 2015, Walker began a fellowship at the ASU-SFI Center for Biosocial Complex Systems as part of a joint educational and research program between Santa Fe Institute and Arizona State University.

Research

Walker is a theoretical physicist and astrobiologist with research interests in the origin of life. [1] [2] She seeks to develop new theories of physics to explain what life is, how it emerged, and what signs of life might look like on other planets. She uses mathematical models to investigate chemical evolution and the development of networks on Prebiotic Earth. [8] She looks at information flow in biotic and abiotic systems to further define life and its emergence. [9] Some of the highlights of her work in this field so far are:

The origin of homochirality

Walker has studied the possible mechanisms of the origin of homochirality, which is a key problem in the origin of life. [10] [11] [12] In her research she has used several models such as the Sandars polymerization model, the Langevin equation, and the activation-polymerization-epimerization-depolymerization (APED) model to imitate potential prebiotic conditions for autocatalytic polymerization networks. Walker et al. discovered that only networks with long polymers show potential to produce significant spontaneous asymmetrical chirality in speculative early Earth conditions. [12] Walker and her colleagues, have also shown that the violent environment of prebiotic Earth would have continuously changed the chirality of reaction networks by a mechanism they termed punctuated chirality. [11] This suggests that the origin of homochirality was not a singular event, and that chiral selection occurred at the same time as the origin of life. Walker and Gleiser also revealed that homochiral proto-domains can form in the middle of racemic networks, and that the slowdown of these networks through processes such as tidal motion or evaporating pools could have led to the stabilization of these structures on early Earth. [10] The results of these simulations have helped to reveal what possibly occurred during the origin of homochiralty, and its effect on the origin of life.

Information flow in biological systems

One of the major challenges in studying the origin of life has been the inability to clearly define what life is. [9] In her investigations, Walker has used the flow of information in systems as a means to distinguish life from non-life. She used the Boolean network model, information theory, and other models to discern feasible universal traits for life. [9] [13] [14] It was shown that in biological systems the components are subordinate to the whole, in what is called top-down causation. [9] Furthermore, a logistical model of Walker et al. suggested that major evolutionary transitions, such as the origin of life, could be characterized by a reverse of information flow in a system from bottom-up to top-down. [15] They also determined that living systems have a separation of data from machinery, and non-trivial replication. Walker has shown theoretically how the occurrence of these biotic traits in an abiotic system present a possible framework for the origin of life. [9]

Public engagement

Walker is an advocate for the communication of science to the public, and has participated in many interviews, panels, and lectures to discuss her research and topics related to her fields of study. [1] She has had press coverage in dozens of news sources, and been active on multiple media platforms. [5] She appeared on the Discover Channel's Through the Wormhole with Morgan Freeman in the episode "Are We Here for a Reason?". She has made two appearances on National Public Radio's Science Friday . [16] She is a co-founder of the astrobiology social network SAGANet, and was a guest scientist on the educational website I'm a Scientist: Get Me Out of Here!. [1] [17]

Organizations

Walker is a member of multiple scientific organizations, including the Blue Marble Space Institute of Science, the NASA Astrobiology Institute, the Foundational Questions Institute (FQXI), and the International Society for Artificial Life, serving on its board of directors. [18] She is also a member of the Complex Systems Society and is on the board of directors for Blue Marble Space. [1] She is a member of the LifeBoat Foundation and serves on its Astrobiology/SETI Advisory Board. [4]

Selected publications

Awards and honors

Walker has won multiple awards for her teaching, writing, lectures, and contributions to her community. She had been awarded several fellowships:

Related Research Articles

<span class="mw-page-title-main">Astrobiology</span> Science concerned with life in the universe

Astrobiology is a scientific field within the life and environmental sciences that studies the origins, early evolution, distribution, and future of life in the universe by investigating its deterministic conditions and contingent events. As a discipline, astrobiology is founded on the premise that life may exist beyond Earth.

<span class="mw-page-title-main">Hypothetical types of biochemistry</span> Possible alternative biochemicals used by life forms

Hypothetical types of biochemistry are forms of biochemistry agreed to be scientifically viable but not proven to exist at this time. The kinds of living organisms currently known on Earth all use carbon compounds for basic structural and metabolic functions, water as a solvent, and DNA or RNA to define and control their form. If life exists on other planets or moons it may be chemically similar, though it is also possible that there are organisms with quite different chemistries – for instance, involving other classes of carbon compounds, compounds of another element, or another solvent in place of water.

Homochirality is a uniformity of chirality, or handedness. Objects are chiral when they cannot be superposed on their mirror images. For example, the left and right hands of a human are approximately mirror images of each other but are not their own mirror images, so they are chiral. In biology, 19 of the 20 natural amino acids are homochiral, being L-chiral (left-handed), while sugars are D-chiral (right-handed). Homochirality can also refer to enantiopure substances in which all the constituents are the same enantiomer, but some sources discourage this use of the term.

<span class="mw-page-title-main">Antonio Lazcano</span> Mexican biology researcher and professor

Antonio Eusebio Lazcano Araujo Reyes is a Mexican biology researcher and professor of the School of Sciences at the National Autonomous University of Mexico in Mexico City. He has studied the origin and early evolution of life for more than 35 years.

<span class="mw-page-title-main">Ronald Breslow</span> American chemist

Ronald Charles David Breslow was an American chemist from Rahway, New Jersey. He was University Professor at Columbia University, where he was based in the Department of Chemistry and affiliated with the Departments of Biological Sciences and Pharmacology; he had also been on the faculty of its Department of Chemical Engineering. He had taught at Columbia since 1956 and was a former chair of the university's chemistry department.

Thermosynthesis is a theoretical mechanism proposed by Anthonie Muller for biological use of the free energy in a temperature gradient to drive energetically uphill anabolic reactions. It makes use of this thermal gradient, or the dissipative structure of convection in this gradient, to drive a microscopic heat engine that performs condensation reactions. Thus negative entropy is generated. The components of the biological thermosynthesis machinery concern progenitors of today's ATP synthase, which functions according to the binding change mechanism, driven by chemiosmosis. Resembling primitive free energy generating physico-chemical processes based on temperature-dependent adsorption to inorganic materials such as clay, this simple type of energy conversion is proposed to have sustained the origin of life, including the emergence of the RNA World. For this RNA World it gives a model that describes the stepwise acquisition of the set of transfer RNAs that sustains the Genetic code. The phylogenetic tree of extant transfer RNAs is consistent with the idea.

<span class="mw-page-title-main">Life on Titan</span> Scientific assessments on the microbial habitability of Titan

Whether there is life on Titan, the largest moon of Saturn, is currently an open question and a topic of scientific assessment and research. Titan is far colder than Earth, but of all the places in the Solar System, Titan is the only place besides Earth known to have liquids in the form of rivers, lakes, and seas on its surface. Its thick atmosphere is chemically active and rich in carbon compounds. On the surface there are small and large bodies of both liquid methane and ethane, and it is likely that there is a layer of liquid water under its ice shell. Some scientists speculate that these liquid mixes may provide prebiotic chemistry for living cells different from those on Earth.

A protocell is a self-organized, endogenously ordered, spherical collection of lipids proposed as a stepping stone toward the origin of life. A central question in evolution is how simple protocells first arose and how they could differ in reproductive output, thus enabling the accumulation of novel biological emergences over time, i.e. biological evolution. Although a functional protocell has not yet been achieved in a laboratory setting, the goal to understand the process appears well within reach.

<span class="mw-page-title-main">Abiogenesis</span> Natural process by which life arises from non-living matter

In biology, abiogenesis or the origin of life is the natural process by which life has arisen from non-living matter, such as simple organic compounds. The prevailing scientific hypothesis is that the transition from non-living to living entities on Earth was not a single event, but a process of increasing complexity involving the formation of a habitable planet, the prebiotic synthesis of organic molecules, molecular self-replication, self-assembly, autocatalysis, and the emergence of cell membranes. Many proposals have been made for different stages of the process.

<span class="mw-page-title-main">Felisa Wolfe-Simon</span> American geomicrobiologist

Felisa Wolfe-Simon is an American microbial geobiologist and biogeochemist. In 2010, Wolfe-Simon led a team that discovered GFAJ-1, an extremophile bacterium that they claimed was capable of substituting arsenic for a small percentage of its phosphorus to sustain its growth, thus advancing the remarkable possibility of non-RNA/DNA-based genetics. However, these conclusions were immediately debated and criticized in correspondence to the original journal of publication, and have since come to be widely disbelieved. In 2012, two reports refuting the most significant aspects of the original results were published in the same journal in which the original findings had been previously published.

SAGANet is a social and collaborative web platform created to connect scientists and science enthusiasts who share interests in the research and culture of astrobiology.

GADV-protein world is a hypothetical stage of abiogenesis. GADV stands for the one letter codes of four amino acids, namely, glycine (G), alanine (A), aspartic acid (D) and valine (V), the main components of GADV proteins. In the GADV-protein world hypothesis, it is argued that the prebiotic chemistry before the emergence of genes involved a stage where GADV-proteins were able to pseudo-replicate. This hypothesis is contrary to the RNA world hypothesis.

<span class="mw-page-title-main">Sandra Pizzarello</span> Italian biochemist

Sandra Pizzarello, D.Bi.Sc. was a Venetian biochemist known for her co-discovery of amino acid enantiomeric excess in carbonaceous chondrite meteorites. Her research interests concerned the characterization of meteoritic organic compounds in elucidating the evolution of planetary homochirality. Pizzarello was a project collaborator and co-investigator for the NASA Astrobiology Institute (NAI), the president of the International Society for the Study of the Origin of Life (2014-2017), and an emerita professor at Arizona State University (ASU).

James "Jim" P. Ferris was an American chemist. He is known for his contributions to the understanding of the origins of life on Earth, specifically by demonstrating a successful mechanism of clay-catalyzed polymerization of RNA, providing further evidence for the RNA World Hypothesis. Additionally, his work in atmospheric photochemistry has illuminated many of the chemical processes which occur in the atmospheres of Jupiter and Saturn's moon, Titan.

Formamide-based prebiotic chemistry is a reconstruction of the beginnings of life on Earth, assuming that formamide could accumulate in sufficiently high amounts to serve as the building block and reaction medium for the synthesis of the first biogenic molecules.

<span class="mw-page-title-main">Betül Kaçar</span> Turkish academic

Betül Kacar is a Turkish-American astrobiologist and an Assistant Professor at the University of Wisconsin. She directs a NASA Astrobiology Research Center exploring the essential attributes of life, its origins and how they should shape our notions of habitability and the search for life on other worlds.

Viedma ripening or attrition-enhanced deracemization is a chiral symmetry breaking phenomenon observed in solid/liquid mixtures of enantiomorphous crystals that are subjected to comminution. It can be classified in the wider area of spontaneous symmetry breaking phenomena observed in chemistry and physics.

<span class="mw-page-title-main">Assembly theory</span> Hypothesis that characterizes object complexity

Assembly theory is a hypothesis that characterizes object complexity. When applied to molecule complexity, its authors claim it to be the first technique that is experimentally verifiable, unlike other molecular complexity algorithms that lack experimental measure. The theory was developed as a means to detect evidence of extraterrestrial life from data gathered by astronomical observations or probes.

A scenario is a set of related concepts pertinent to the origin of life (abiogenesis), such as the iron-sulfur world. Many alternative abiogenesis scenarios have been proposed by scientists in a variety of fields from the 1950s onwards in an attempt to explain how the complex mechanisms of life could have come into existence. These include hypothesized ancient environments that might have been favourable for the origin of life, and possible biochemical mechanisms.

<span class="mw-page-title-main">Prebiotic atmosphere</span>

The prebiotic atmosphere is the second atmosphere present on Earth before today's biotic, oxygen-rich third atmosphere, and after the first atmosphere of Earth's formation. The formation of the Earth, roughly 4.5 billion years ago, involved multiple collisions and coalescence of planetary embryos. This was followed by a <100 million year period on Earth where a magma ocean was present, the atmosphere was mainly steam, and surface temperatures reached up to 8,000 K (14,000 °F). Earth's surface then cooled and the atmosphere stabilized, establishing the prebiotic atmosphere. The environmental conditions during this time period were quite different from today: the Sun was ~30% dimmer overall yet brighter at ultraviolet and x-ray wavelengths, there was a liquid ocean, it is unknown if there were continents but oceanic islands were likely, Earth's interior chemistry was different, and there was a larger flux of impactors hitting Earth's surface.

References

  1. 1 2 3 4 5 6 7 "saraimariwalker". Sara Imari Walker [website appears hacked on 2023-05-03]. Retrieved 2016-11-06.
  2. 1 2 "Emergence@ASU". Emergence@ASU. Retrieved 2016-11-06.
  3. 1 2 "Sara Walker | iSearch". isearch.asu.edu. Retrieved 2016-11-15.
  4. 1 2 3 4 "Lifeboat Foundation Bios: Dr. Sara Imari Walker". lifeboat.com. Retrieved 2016-11-15.
  5. 1 2 "Media". Emergence@ASU. Retrieved 2016-11-15.
  6. "Recent PhD Graduates | Department of Physics and Astronomy". physics.dartmouth.edu. 18 June 2014. Retrieved 2016-11-15.
  7. "Sara Walker". Emergence@ASU. Retrieved 2016-11-15.
  8. Cronin, Leroy; Walker, Sara Imari (2016-06-03). "Beyond prebiotic chemistry" (PDF). Science . 352 (6290): 1174–1175. Bibcode:2016Sci...352.1174C. doi:10.1126/science.aaf6310. PMID   27257242. S2CID   206649123.
  9. 1 2 3 4 5 Walker, Sara Imari; Davies, Paul C. W. (2013-02-06). "The algorithmic origins of life". Journal of the Royal Society Interface . 10 (79): 20120869. arXiv: 1207.4803 . doi:10.1098/rsif.2012.0869. PMC   3565706 . PMID   23235265.
  10. 1 2 Gleiser, Marcelo; Walker, Sara Imari (2009-04-16). "Toward Homochiral Protocells in Noncatalytic Peptide Systems". Origins of Life and Evolution of Biospheres . 39 (5): 479–493. arXiv: 0810.5398 . Bibcode:2009OLEB...39..479G. doi:10.1007/s11084-009-9166-5. PMID   19370399. S2CID   14040409.
  11. 1 2 Gleiser, Marcelo; Thorarinson, Joel; Walker, Sara Imari (2008-10-08). "Punctuated Chirality". Origins of Life and Evolution of Biospheres. 38 (6): 499–508. arXiv: 0802.1446 . Bibcode:2008OLEB...38..499G. doi:10.1007/s11084-008-9147-0. PMID   18841492. S2CID   7005075.
  12. 1 2 Gleiser, Marcelo; Walker, Sara Imari (2008-05-09). "An Extended Model for the Evolution of Prebiotic Homochirality: A Bottom-Up Approach to the Origin of Life". Origins of Life and Evolution of Biospheres. 38 (4): 293–315. arXiv: 0802.2884 . Bibcode:2008OLEB...38..293G. doi:10.1007/s11084-008-9134-5. PMID   18465201. S2CID   18929297.
  13. Walker, Sara Imari; Kim, Hyunju; Davies, Paul C. W. (2016-03-13). "The informational architecture of the cell". Philosophical Transactions of the Royal Society A . 374 (2063): 20150057. arXiv: 1507.03877 . Bibcode:2016RSPTA.37450057W. doi:10.1098/rsta.2015.0057. PMID   26857675. S2CID   683771.
  14. Davies, Paul C. W.; Walker, Sara Imari (2016-01-01). "The hidden simplicity of biology". Reports on Progress in Physics . 79 (10): 102601. Bibcode:2016RPPh...79j2601D. doi:10.1088/0034-4885/79/10/102601. PMID   27608530. S2CID   4374728.
  15. Walker, Sara Imari; Cisneros, Luis; Davies, Paul C. W. (2012-07-19). "Evolutionary Transitions and Top-Down Causation". Proceedings of Artificial Life XIII () P. 2012: 283–290. arXiv: 1207.4808 . Bibcode:2012arXiv1207.4808I. doi:10.7551/978-0-262-31050-5-ch038. ISBN   9780262310505. S2CID   11189805.
  16. Minoff, Annie (August 5, 2014). "Meet the 'Dune' Readers: Kim Stanley Robinson and Sara Imari Walker". Science Friday.
  17. "Profile – Calcium Zone". calciumj11.imascientist.org.uk. Retrieved 2016-11-15.
  18. "List of International Society for Artificial Life Board Members". International Society for Artificial Life. Retrieved 22 May 2021.
  19. "FQXi Essay Contest 2015". FQXi Community. Retrieved 10 July 2021.
  20. "FQXi Essay Contest 2012". FQXi Community. Retrieved 10 July 2021.