Scott A. Small

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Scott A. Small
Scott A. Small.png
Alma mater New York University (BA)
Columbia University (MD)
Scientific career
FieldsNeurobiology of Disease
InstitutionsColumbia University
Doctoral advisor Eric Kandel

Scott A. Small is an American neurologist and neuroscientist known for his work in Alzheimer's disease and normal cognitive aging. [1] His research focuses on the hippocampus, a circuit in the brain targeted by Alzheimer's disease, aging, and schizophrenia. Small is the Director of the Alzheimer's Disease Research Center at Columbia University, where he is the Boris and Rose Katz Professor of Neurology. He is also appointed in Radiology and in Psychiatry.

Work

Small has developed high-resolution functional MRI applications that can pinpoint the areas of the hippocampus most affected by aging and disease. [2] His lab uses this ‘anatomical biology’ approach of isolating pathogenic mechanisms to identify potential causes of these disorders and inform on drug discovery and development. [3] [4] [5] [6] To date, these mechanistic insights have led to the testing of therapeutic interventions for three hippocampal-based conditions: retromer-enhancers for Alzheimer's disease; [7] [8] dietary flavanols for cognitive aging; [9] and glutamate-reducers for schizophrenia. [6]

Small has authored more than 140 papers and is an inventor of 10 patents. [1]  He is the author of the 2021 book, Forgetting: The Benefits of Not Remembering, published by Crown/Penguin Random House ( ISBN   978-0-593-13619-5).

References

  1. 1 2 "Scott A. Small". scholar.google.com. Retrieved 2021-03-05.
  2. ↑ Small, Scott A.; Schobel, Scott A.; Buxton, Richard B.; Witter, Menno P.; Barnes, Carol A. (October 2011). "A pathophysiological framework of hippocampal dysfunction in ageing and disease". Nature Reviews Neuroscience. 12 (10): 585–601. doi:10.1038/nrn3085. ISSN   1471-0048. PMC   3312472 . PMID   21897434.
  3. ↑ Small, Scott A. (2014-10-01). "Isolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability". Neuron. 84 (1): 32–39. doi:10.1016/j.neuron.2014.08.030. ISSN   1097-4199. PMC   4185396 . PMID   25277453.
  4. ↑ Small, Scott A.; Petsko, Gregory A. (March 2015). "Retromer in Alzheimer disease, Parkinson disease and other neurological disorders". Nature Reviews. Neuroscience. 16 (3): 126–132. doi:10.1038/nrn3896. ISSN   1471-0048. PMID   25669742. S2CID   5166260.
  5. ↑ Brickman, Adam M.; Khan, Usman A.; Provenzano, Frank A.; Yeung, Lok-Kin; Suzuki, Wendy; Schroeter, Hagen; Wall, Melanie; Sloan, Richard P.; Small, Scott A. (December 2014). "Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults". Nature Neuroscience. 17 (12): 1798–1803. doi:10.1038/nn.3850. ISSN   1546-1726. PMC   4940121 . PMID   25344629.
  6. 1 2 Schobel, Scott A.; Chaudhury, Nashid H.; Khan, Usman A.; Paniagua, Beatriz; Styner, Martin A.; Asllani, Iris; Inbar, Benjamin P.; Corcoran, Cheryl M.; Lieberman, Jeffrey A.; Moore, Holly; Small, Scott A. (2013-04-10). "Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver". Neuron. 78 (1): 81–93. doi:10.1016/j.neuron.2013.02.011. ISSN   1097-4199. PMC   3966570 . PMID   23583108.
  7. ↑ Mecozzi, Vincent J.; Berman, Diego E.; Simoes, Sabrina; Vetanovetz, Chris; Awal, Mehraj R.; Patel, Vivek M.; Schneider, Remy T.; Petsko, Gregory A.; Ringe, Dagmar; Small, Scott A. (June 2014). "Pharmacological chaperones stabilize retromer to limit APP processing". Nature Chemical Biology. 10 (6): 443–449. doi:10.1038/nchembio.1508. ISSN   1552-4469. PMC   4076047 . PMID   24747528.
  8. ↑ Small, Scott A.; Petsko, Gregory A. (2020-12-02). "Endosomal recycling reconciles the Alzheimer's disease paradox". Science Translational Medicine. 12 (572): eabb1717. doi:10.1126/scitranslmed.abb1717. ISSN   1946-6234. PMC   8025181 . PMID   33268506. S2CID   227249225.
  9. ↑ Sloan, Richard P.; Wall, Melanie; Yeung, Lok-Kin; Feng, Tianshu; Feng, Xinyang; Provenzano, Frank; Schroeter, Hagen; Lauriola, Vincenzo; Brickman, Adam M.; Small, Scott A. (2021-02-15). "Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial". Scientific Reports. 11 (1): 3837. doi: 10.1038/s41598-021-83370-2 . ISSN   2045-2322. PMC   7884710 . PMID   33589674.
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