Sebaceous filament

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Sebaceous filament
Other namesBlackhead (mistakenly)
Blackheads.JPG
A 14-year-old with characteristic black kind of sebaceous filaments on the nose
Specialty Dermatology
Treatment Retinol topical cream

A sebaceous filament is a tiny collection of sebum and dead skin cells around a hair follicle, which usually takes the form of a small, yellow to off-white hair-like strand when expressed from the skin. [1] [2]

These filaments are naturally occurring, and are especially prominent on the nose. [3] [4] They are typical among those with naturally oily skin and large pores, even if those individuals have ceased to produce acne. [4] They are not a sign of infection or any other ailment including acne, [5] and are commonly mistaken for, though cannot form, [6] blackheads. Expression, or squeezing, is discouraged as sebaceous filaments are a natural part of healthy human skin. As such, squeezing can lead to unintentional unnecessary harm, such as scarring or inflammation. They help to channel the flow of sebum within a given pore, allowing it to seep gradually to the surface. In 1979, David A. Whiting described them in a review in the Western Journal of Medicine as "a loose, porous mass of horned detritus". [1]

Sebocytes actively participate in innate immunity by releasing cytokines like IL-1α, IL-6, and TNF-α. [7]

References

  1. 1 2 Whiting, D. A. (1979). "Acne". The Western Journal of Medicine. 131 (6): 551–557. PMC   1271924 . PMID   161830.
  2. Plewig, Gerd; Melnik, Bodo; WenChieh, Chen (2019). Plewig and Kligman's Acne and Rosacea (4th ed.). Basel: Springer Nature Switzerland. p. 2.
  3. Plewig, Gerd; Wolff, H. H. (1976). "Sebaceous filaments". Archiv für Dermatologische Forschung. 255 (1): 9–21. doi:10.1007/BF00581673. PMID   130839.
  4. 1 2 Plewig, Melnik & WenChieh (2019), p. 64.
  5. Plewig, Melnik & WenChieh (2019), p. 16.
  6. Plewig, Melnik & WenChieh (2019), p. 26.
  7. Zouboulis, Christos C.; Coenye, Tom; He, Li; Kabashima, Kenji; Kobayashi, Tetsuro; Niemann, Catherin; Nomura, Takashi; Oláh, Attila; Picardo, Mauro; Quist, Sven R.; Sasano, Hironobu; Schneider, Marlon R.; Törőcsik, Daniel; Wong, Sunny Y. (November 10, 2022). "Sebaceous immunobiology - skin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations". Frontiers in Immunology. 13. doi: 10.3389/fimmu.2022.1029818 . PMC   9686445 .