Semenogelin I

SEMG1
Identifiers
Aliases	SEMG1 , CT103, SEMG, SGI, dJ172H20.2, Semenogelin I, semenogelin 1
External IDs	OMIM: 182140 HomoloGene: 130511 GeneCards: SEMG1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,209,768 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; sperm; ; prostate; ; gallbladder; ; thymus; ; synovial joint; ; blood; ; islet of Langerhans; ; urinary bladder; ; pharynx;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding ; metal ion binding ; zinc ion binding ;
Cellular component	extracellular region ; extracellular exosome ; nucleus ; extracellular space ; protein-containing complex ;
Biological process	negative regulation of calcium ion import ; insemination ; antibacterial humoral response ; positive regulation of serine-type endopeptidase activity ; protein heterooligomerization ; negative regulation of flagellated sperm motility ; antimicrobial humoral response ; coagulation ; sperm capacitation ;
	Sources:Amigo / QuickGO
Orthologs
	6406
	n/a
	ENSG00000124233
	n/a
	P04279
	n/a
	NM_198139 ; NM_003007
	n/a
	NP_002998
	n/a
	Wikidata
View/Edit Human

Last updated December 24, 2023

Semenogelin-1 is a protein that in humans is encoded by the SEMG1 gene.^[3]^[4]^[5] The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.^[5]

Related Research Articles

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.

<span class="mw-page-title-main">Acrosin</span> Mammalian protein found in Homo sapiens

Acrosin is a digestive enzyme that acts as a protease. In humans, acrosin is encoded by the ACR gene. Acrosin is released from the acrosome of spermatozoa as a consequence of the acrosome reaction. It aids in the penetration of the Zona Pellucida.

Semenogelase is an enzyme. This enzyme catalyses the following chemical reaction

Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. These genes are localised to chromosome 19q13, forming the largest contiguous cluster of proteases within the human genome. Kallikreins are responsible for the coordination of various physiological functions including blood pressure, semen liquefaction and skin desquamation.

Leucyl/cystinyl aminopeptidase, also known as cystinyl aminopeptidase (CAP), insulin-regulated aminopeptidase (IRAP), human placental leucine aminopeptidase (PLAP), oxytocinase, and vasopressinase, is an enzyme of the aminopeptidase group that in humans is encoded by the LNPEP gene.

Protein C inhibitor is a serine protease inhibitor (serpin) that limits the activity of protein C.

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family.

Kallikrein-2 is a protein that in humans is encoded by the KLK2 gene, and is particularly associated with prostatic tissue.

Inhibin, alpha, also known as INHA, is a protein which in humans is encoded by the INHA gene.

Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma carboxypeptidase B (pCPB) or thrombin-activatable fibrinolysis inhibitor (TAFI), is an enzyme that, in humans, is encoded by the gene CPB2.

Beta-microseminoprotein is a protein that in humans is encoded by the MSMB gene. For historical reasons, the scientific literature may also refer to this protein as Prostate secretory protein 94 (PSP94), microseminoprotein (MSP), microseminoprotein-beta (MSMB), beta-inhibitin, prostatic inhibin peptide (PIP), and inhibitin like material (ILM).

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene.

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene.

Semenogelin-2 is a protein that in humans is encoded by the SEMG2 gene.

Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene.

Cysteine-rich secretory protein 3 is a cysteine-rich secretory protein that in humans is encoded by the CRISP3 gene.

<span class="mw-page-title-main">KLK8</span> Protein-coding gene in the species Homo sapiens

Kallikrein-8 is a protein that in humans is encoded by the KLK8 gene.

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene.

T-cell surface glycoprotein CD3 delta chain is a protein that in humans is encoded by the CD3D gene.

Semenogelin is a protein that is involved in the formation of a gel matrix that encases ejaculated spermatozoa, preventing capacitation. It blocks capacitation mainly via inhibition of reactive oxygen species (ROS) generation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124233 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lilja H, Abrahamsson PA, Lundwall A (Mar 1989). "Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa". J Biol Chem. 264 (3): 1894–900. doi: 10.1016/S0021-9258(18)94272-9 . PMID 2912989.
↑ Jonsson M, Linse S, Frohm B, Lundwall A, Malm J (Apr 2005). "Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen". Biochem J. 387 (Pt 2): 447–53. doi:10.1042/BJ20041424. PMC 1134973 . PMID 15563730.
1 2 "Entrez Gene: SEMG1 semenogelin I".

Robert M, Gagnon C (1999). "Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein". Cell. Mol. Life Sci. 55 (6–7): 944–60. doi:10.1007/s000180050346. PMID 10412373. S2CID 31516685.
Ulvsbäck M, Lazure C, Lilja H, et al. (1992). "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20". J. Biol. Chem. 267 (25): 18080–4. doi: 10.1016/S0021-9258(19)37155-8 . PMID 1517240.
Schneider K, Kausler W, Tripier D, et al. (1989). "[Isolation and structure determination of two peptides occurring in human seminal plasma]". Biol. Chem. Hoppe-Seyler. 370 (4): 353–6. doi:10.1515/bchm3.1989.370.1.353. PMID 2757795.
Li CH, Hammonds RG, Ramasharma K, Chung D (1985). "Human seminal alpha inhibins: isolation, characterization, and structure". Proc. Natl. Acad. Sci. U.S.A. 82 (12): 4041–4. Bibcode:1985PNAS...82.4041L. doi: 10.1073/pnas.82.12.4041 . PMC 397930 . PMID 3889920.
Lilja H, Jeppsson JO (1985). "Amino acid sequence of the predominant basic protein in human seminal plasma". FEBS Lett. 182 (1): 181–4. doi: 10.1016/0014-5793(85)81179-0 . PMID 3972122. S2CID 31277428.
Ramasharma K, Sairam MR, Seidah NG, et al. (1984). "Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity". Science. 223 (4641): 1199–202. Bibcode:1984Sci...223.1199R. doi:10.1126/science.6422553. PMID 6422553.
Lilja H, Laurell CB, Jeppsson JO (1984). "Characterization of the predominant basic protein in human seminal plasma, one cleavage product of the major seminal vesicle protein". Scand. J. Clin. Lab. Invest. 44 (5): 439–46. doi:10.3109/00365518409083835. PMID 6484484.
Seidah NG, Ramasharma K, Sairam MR, Chrétien M (1984). "Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity". FEBS Lett. 167 (1): 98–102. doi: 10.1016/0014-5793(84)80840-6 . PMID 6698208. S2CID 27647296.
Khan Z, Smyth DG (1993). "Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen". Eur. J. Biochem. 212 (1): 35–40. doi: 10.1111/j.1432-1033.1993.tb17629.x . PMID 8444163.
Lundwall A (1996). "The structure of the semenogelin gene locus--nucleotide sequence of the intergenic and the flanking DNA". Eur. J. Biochem. 235 (3): 466–70. doi: 10.1111/j.1432-1033.1996.00466.x . PMID 8654389.
Malm J, Hellman J, Magnusson H, et al. (1996). "Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II". Eur. J. Biochem. 238 (1): 48–53. doi: 10.1111/j.1432-1033.1996.0048q.x . PMID 8665951.
Bjartell A, Malm J, Moller C, et al. (1997). "Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry". J. Androl. 17 (1): 17–26. doi:10.1002/j.1939-4640.1996.tb00582.x. PMID 8833737. S2CID 20337870.
Robert M, Gibbs BF, Jacobson E, Gagnon C (1997). "Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor/semenogelin I.". Biochemistry. 36 (13): 3811–9. doi:10.1021/bi9626158. PMID 9092810.
Peter A, Lilja H, Lundwall A, Malm J (1998). "Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase". Eur. J. Biochem. 252 (2): 216–21. doi: 10.1046/j.1432-1327.1998.2520216.x . PMID 9523691.
Lövgren J, Airas K, Lilja H (1999). "Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors". Eur. J. Biochem. 262 (3): 781–9. doi: 10.1046/j.1432-1327.1999.00433.x . PMID 10411640.
Malm J, Hellman J, Hogg P, Lilja H (2000). "Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor". Prostate. 45 (2): 132–9. doi:10.1002/1097-0045(20001001)45:2<132::AID-PROS7>3.0.CO;2-3. PMID 11027412. S2CID 35309283.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Brillard-Bourdet M, Réhault S, Juliano L, et al. (2002). "Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates". Eur. J. Biochem. 269 (1): 390–5. doi: 10.1046/j.0014-2956.2001.02667.x . PMID 11784334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124233 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2912989-3] Lilja H, Abrahamsson PA, Lundwall A (Mar 1989). "Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa". J Biol Chem. 264 (3): 1894–900. doi: 10.1016/S0021-9258(18)94272-9 . PMID 2912989.

[pmid15563730-4] Jonsson M, Linse S, Frohm B, Lundwall A, Malm J (Apr 2005). "Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen". Biochem J. 387 (Pt 2): 447–53. doi:10.1042/BJ20041424. PMC 1134973 . PMID 15563730.

[entrez-5] 1 2 "Entrez Gene: SEMG1 semenogelin I".

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Semenogelin I

Contents

See also

Related Research Articles

References

Further reading