Serine hydroxymethyltransferase 2

SHMT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OU5, 4PVF
Identifiers
Aliases	SHMT2 , GLYA, HEL-S-51e, SHMT, serine hydroxymethyltransferase 2, NEDCASB
External IDs	OMIM: 138450 MGI: 1277989 HomoloGene: 133984 GeneCards: SHMT2
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,234,935 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,358,313 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; oocyte; ; stromal cell of endometrium; ; secondary oocyte; ; embryo; ; body of pancreas; ; tibia; ; ganglionic eminence; ; parotid gland; ; lymph node;
	Top expressed in
	left lobe of liver; ; condyle; ; kidney; ; yolk sac; ; proximal tubule; ; internal carotid artery; ; somite; ; calvaria; ; fossa; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity ; amino acid binding ; chromatin binding ; L-allo-threonine aldolase activity ; protein binding ; catalytic activity ; identical protein binding ; glycine hydroxymethyltransferase activity ; pyridoxal phosphate binding ; zinc ion binding ; cobalt ion binding ; serine binding ;
Cellular component	membrane ; BRISC complex ; microtubule cytoskeleton ; mitochondrial intermembrane space ; extracellular exosome ; mitochondrial inner membrane ; cytoplasm ; mitochondrion ; mitochondrial matrix ; mitochondrial nucleoid ; nucleus ;
Biological process	L-serine biosynthetic process ; tetrahydrofolate interconversion ; protein tetramerization ; tetrahydrofolate metabolic process ; protein K63-linked deubiquitination ; folic acid metabolic process ; glycine biosynthetic process from serine ; response to type I interferon ; positive regulation of cell population proliferation ; glycine biosynthetic process ; protein homotetramerization ; one-carbon metabolic process ; glycine metabolic process ; L-serine metabolic process ; regulation of oxidative phosphorylation ; L-serine catabolic process ; regulation of mitochondrial translation ; regulation of aerobic respiration ; cellular response to tetrahydrofolate ;
	Sources:Amigo / QuickGO
Orthologs
	6472
	108037
	ENSG00000182199
	ENSMUSG00000025403
	P34897
	Q9CZN7
	NM_001166356 ; NM_001166357 ; NM_001166358 ; NM_001166359 ; NM_005412
	NM_001252316 ; NM_028230
	NP_001159828 ; NP_001159829 ; NP_001159830 ; NP_001159831 ; NP_005403
	NP_001239245 ; NP_082506
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 15, 2022

Serine hydroxymethyltransferase 2 is an enzyme that in humans is encoded by the SHMT2 gene.^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182199 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025403 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Anderson DD, Stover PJ (June 2009). "SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis". PLOS ONE. 4 (6): e5839. Bibcode:2009PLoSO...4.5839A. doi: 10.1371/journal.pone.0005839 . PMC 2688753 . PMID 19513116.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182199 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025403 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid19513116-5] Anderson DD, Stover PJ (June 2009). "SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis". PLOS ONE. 4 (6): e5839. Bibcode:2009PLoSO...4.5839A. doi: 10.1371/journal.pone.0005839 . PMC 2688753 . PMID 19513116.

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