Sonia M. Vallabh | |
|---|---|
| Vallabh in 2025 | |
| Occupation | Researcher |
| Spouse | Eric Vallabh Minikel |
| Academic background | |
| Alma mater | Harvard University |
| Thesis | Antisense Oligonucleotides for the Prevention of Genetic Prion Disease (2019) |
| Doctoral advisor | Stuart L. Schreiber |
| Academic work | |
| Discipline | Biological and Biomedical Sciences |
Sonia Minikel Vallabh is an American scientist focused on prion diseases,particularly fatal familial insomnia. She is noted for being a "patient-scientist" that proactively studies a genetic disorder she is a patient for,aiming to cure it before it kills her. [1] [2] [3]
Before beginning her career as a scientist,Vallabh studied and practiced law,having graduated from Harvard Law School and Swarthmore College. [4] In 2010,her mother,Kanmi,suddenly developed profound and aggressive dementia that killed her six months after symptoms first developed. An autopsy revealed that her mother had died from fatal familial insomnia,an incurable genetic disorder that causes misfolded proteins to destroy the brain. A blood sample from Vallabh herself revealed she had inherited the causal mutation. [5]
The revelation inspired Vallabh and her husband,Eric Vallabh Minikel,to retrain as biomedical scientists with the goal of saving her life. [6] [7] She received a Doctorate of Philosophy from Harvard in 2019 and became a senior leader at the Broad Institute prion lab. [8]
In 2023,she earned the Paper of the Year Award from the Oligonucleotide Therapeutics Society. [9]
As of 2025,prion diseases remain invariably fatal. However,research published by Vallabh and her husband in 2025 may represent the first steps towards treatment,having prolonged the lives of rats with prion disease by 52%. [10] [11]