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| Products | nQuery Sample Size Software |
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Statsols (formerly known as Statistical Solutions) is the producer and distributor of the proprietary nQuery sample size software.
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| Products | nQuery Sample Size Software |
|---|---|
Statsols (formerly known as Statistical Solutions) is the producer and distributor of the proprietary nQuery sample size software.
In 1984, Statsols (Originally known as Statistical Solutions [1] ) was a distributor for the statistical software BMDP. This was statistical package developed in 1965 by Wilfrid Joseph Dixon at the University of California, Los Angeles, which performed different parametric and nonparametric statistical analyses. [2]
Through a management buy-out in 1995, President & CEO Mary Byrne who led the all-female buy-out, which was not common at the time, to form the independent company Statistical Solutions Ltd, now known as Statsols. The company now only offers its most successful statistical product, nQuery Sample Size Software. [3]
Janet Dixon Elashoff is a now-retired American statistician and daughter of the mathematician and statistician Wilfrid Joseph Dixon, creator of BMDP. Janet is the retired Director of the Division of Biostatistics, Cedars-Sinai Medical Center. While at UCLA and Cedars-Sinai during the 1990s, she wrote the program nQuery Sample Size Software (then known as nQuery Advisor). This quickly became widely used to estimate the sample size requirements for pharmaceutical testing and she joined the company Statistical Solutions LLC to commercialize it. [4]
Through many iterations, nQuery Sample Size Software remains widely used in the pharmaceutical industry for the purpose of calculating sample size and for the determination of power for clinical trials. The US National Institutes of Health Library lists over 895 published studies that used nQuery for sample size calculation that are freely available to the public to view [5] . Other public directories available for further research include Google Scholar where there are over 6,000 scientific studies that feature nQuery available to the public for scientific research. [6]
Biostatistics are the development and application of statistical methods to a wide range of topics in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experiments and the interpretation of the results.
A tolerance interval is a statistical interval within which, with some confidence level, a specified proportion of a sampled population falls. "More specifically, a 100×p%/100×(1−α) tolerance interval provides limits within which at least a certain proportion (p) of the population falls with a given level of confidence (1−α)." "A tolerance interval (TI) based on a sample is constructed so that it would include at least a proportion p of the sampled population with confidence 1−α; such a TI is usually referred to as p-content − (1−α) coverage TI." "A upper tolerance limit (TL) is simply a 1−α upper confidence limit for the 100 p percentile of the population."
The Kruskal–Wallis test by ranks, Kruskal–Wallis H test, or one-way ANOVA on ranks is a non-parametric method for testing whether samples originate from the same distribution. It is used for comparing two or more independent samples of equal or different sample sizes. It extends the Mann–Whitney U test, which is used for comparing only two groups. The parametric equivalent of the Kruskal–Wallis test is the one-way analysis of variance (ANOVA).
In statistics, an exact (significance) test is a test where if the null hypothesis is true then all assumptions, upon which the derivation of the distribution of the test statistic is based, are met. Using an exact test provides a significance test that keeps the Type I error rate of the test at the desired significance level of the test. For example an exact test at significance level of , when repeating the test over many samples where the null hypotheses is true, will reject at most of the time. This is opposed to an approximate test in which the desired type I error rate is only approximately kept, while this approximation may be made as close to as desired by making the sample size big enough.
Sir David John Spiegelhalter is a British statistician and Winton Professor of the Public Understanding of Risk in the Statistical Laboratory at the University of Cambridge and a Fellow of Churchill College, Cambridge. Spiegelhalter is an ISI highly cited researcher.
In statistics, sequential analysis or sequential hypothesis testing is statistical analysis where the sample size is not fixed in advance. Instead data are evaluated as they are collected, and further sampling is stopped.
BMDP was a statistical package developed in 1965 by Wilfrid Dixon at the University of California, Los Angeles. The acronym stands for Bio-Medical Data Package, the word package was added by Dixon as the software consisted of a series of programs (subroutines) which performed different parametric and nonparametric statistical analyses.
In statistics, a generalized estimating equation (GEE) is used to estimate the parameters of a generalized linear model with a possible unknown correlation between outcomes.
Cytel is a multinational statistical software developer and contract research organization, headquartered in Cambridge, Massachusetts, USA. Cytel provides clinical trial design, implementation services, and statistical products primarily for the biotech and pharmaceutical development markets.
Pranab Kumar Sen is a statistician, a professor of statistics and the Cary C. Boshamer Professor of Biostatistics at the University of North Carolina at Chapel Hill.
Wilfrid Joseph Dixon was an American mathematician and statistician. He made notable contributions to nonparametric statistics.
Rafael Irizarry is a professor of biostatistics at the Harvard T.H. Chan School of Public Health and professor of biostatistics and computational biology at the Dana–Farber Cancer Institute. Irizarry is known as one of the founders of the Bioconductor project.
Janet Dixon Elashoff is a retired American statistician, formerly the director of biostatistics for Cedars-Sinai Medical Center and professor of biomathematics at the University of California, Los Angeles.
Kim-Anh Do is an Australian biostatistician of Vietnamese descent. She is the chair of the Department of Biostatistics in the University of Texas MD Anderson Cancer Center, and the holder of the Electa C. Taylor Chair for Cancer Research at the center. She also holds adjunct professorships at Texas A&M University and Rice University.
Lien-Ju Anne Chao is a Taiwanese environmental statistician. She works in the Institute of Statistics at National Tsing Hua University, where she is Tsing Hua Distinguished Chair Professor and a former Taiwan National Chair Professor. Chao has described herself as "60% statistician, 30% mathematician and 10% ecologist". She is known for her work on mark and recapture methods for estimating the size and diversity of populations. She has authored or co-authored a number of software tools for quantifying and estimating biological diversity, and her scholarly works have been cited more than 23,000 times as of November 2019.
nQuery is a clinical trial design platform used for the design and monitoring of adaptive, group sequential and fixed sample size trials. It is most commonly used by Biostatisticians to calculate Sample size and Statistical power for adaptive clinical trial design. nQuery is proprietary software developed and distributed by Statsols. nQuery includes calculations for 1000+ sample size and power scenarios.
Janet Turk Wittes is an American statistician known for her work on clinical trials.
Nicola G. "Nicky" Best is a statistician known for her work on the deviance information criterion in Bayesian inference and as a developer of Bayesian inference using Gibbs sampling. She is a former professor of biostatistics and epidemiology at Imperial College London and is currently a biostatistician for GlaxoSmithKline.