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An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the common cold or influenza; drugs which inhibit viruses are termed antiviral drugs or antivirals rather than antibiotics.
Escherichia coli, also known as E. coli, is a Gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms. Most E. coli strains are harmless, but some serotypes (EPEC, ETEC etc.) can cause serious food poisoning in their hosts, and are occasionally responsible for food contamination incidents that prompt product recalls. The harmless strains are part of the normal microbiota of the gut, and can benefit their hosts by producing vitamin K2, and preventing colonisation of the intestine with pathogenic bacteria, having a mutualistic relationship. E. coli is expelled into the environment within fecal matter. The bacterium grows massively in fresh fecal matter under aerobic conditions for 3 days, but its numbers decline slowly afterwards.
Escherichia coli O157:H7 is a serotype of the bacterial species Escherichia coli and is one of the Shiga-like toxin–producing types of E. coli. It is a cause of disease, typically foodborne illness, through consumption of contaminated and raw food, including raw milk and undercooked ground beef. Infection with this type of pathogenic bacteria may lead to hemorrhagic diarrhea, and to kidney failure; these have been reported to cause the deaths of children younger than five years of age, of elderly patients, and of patients whose immune systems are otherwise compromised.
Shigellosis is an infection of the intestines caused by Shigella bacteria. Symptoms generally start one to two days after exposure and include diarrhea, fever, abdominal pain, and feeling the need to pass stools even when the bowels are empty. The diarrhea may be bloody. Symptoms typically last five to seven days and it may take several months before bowel habits return entirely to normal. Complications can include reactive arthritis, sepsis, seizures, and hemolytic uremic syndrome.
Shigella is a genus of bacteria that is Gram-negative, facultative anaerobic, non-spore-forming, nonmotile, rod-shaped, and genetically closely related to E. coli. The genus is named after Kiyoshi Shiga, who first discovered it in 1897.
An antimicrobial is an agent that kills microorganisms or stops their growth. Antimicrobial medicines can be grouped according to the microorganisms they act primarily against. For example, antibiotics are used against bacteria, and antifungals are used against fungi. They can also be classified according to their function. Agents that kill microbes are microbicides, while those that merely inhibit their growth are called bacteriostatic agents. The use of antimicrobial medicines to treat infection is known as antimicrobial chemotherapy, while the use of antimicrobial medicines to prevent infection is known as antimicrobial prophylaxis.
Esther Miriam Zimmer Lederberg was an American microbiologist and a pioneer of bacterial genetics. She discovered the bacterial virus λ and the bacterial fertility factor F, devised the first implementation of replica plating, and furthered the understanding of the transfer of genes between bacteria by specialized transduction.
Thomas Hugh Pennington, CBE, FRCPath, FRCP (Edin), FMedSci, FRSE is emeritus professor of bacteriology at the University of Aberdeen, Scotland. Outside academia, he is best known as the chair of the Pennington Group enquiry into the Scottish Escherichia coli outbreak of 1996 and as Chairman of the Public Inquiry into the 2005 Outbreak of E. coli O157 in South Wales.
Peperomia pellucida is an annual, shallow-rooted herb, usually growing to a height of about 15 to 45 cm, it is characterized by succulent stems, shiny, heart-shaped, fleshy leaves and tiny, dot-like seeds attached to several fruiting spikes. It has a mustard-like odor when crushed. The family Piperaceae comprises about a dozen genera and around 3000 species. The genus Peperomia represents nearly half of the Piperaceae with the genus Piper making the rest.
Copper and its alloys are natural antimicrobial materials. Ancient civilizations exploited the antimicrobial properties of copper long before the concept of microbes became understood in the nineteenth century. In addition to several copper medicinal preparations, it was also observed centuries ago that water contained in copper vessels or transported in copper conveyance systems was of better quality than water contained or transported in other materials.
Ruth Milne Hall, OAM, FAA, FAAM is an Australian microbiologist whose research on mobile genetic elements in bacteria has provided deep insight into the transfer and evolution of antibiotic resistance in bacteria.
Ameyo Adadevoh was a Nigerian physician.
Dipshikha Chakravortty is an Indian microbiologist, molecular pathologist and a professor at the department of Microbiology and Cell Biology at the Indian Institute of Science. Known for her studies on Salmonella and antibacterial resistance, Chakravortty is an elected fellow of the National Academy of Sciences, India, the Indian Academy of Sciences and the Indian National Science Academy. The Department of Biotechnology of the Government of India awarded her the National Bioscience Award for Career Development, one of the highest Indian science awards, for her contributions to biosciences, in 2010.
Folasade Tolulope Ogunsola is a Nigerian professor of medical microbiology. She specializes in disease control, particularly HIV/AIDS. Ogunsola was provost of College of Medicine, University of Lagos and is reputed as being the first woman to occupy the position. She was also the Deputy Vice Chancellor of the institution between 2017 and 2021. She was elected as the acting vice chancellor of University of Lagos on August 24, 2020, by the university's senate.
Colin Hughes PhD ScD FLSW is a British microbiologist who has worked in the areas of bacterial virulence, motility and antibiotic resistance. He is Emeritus Professor of Microbiology at the University of Cambridge, Fellow of Trinity College Cambridge, and Fellow of the Learned Society of Wales.
Cassandra Leah Quave is an American ethnobotanist, herbarium curator, and associate professor at Emory University. Her research focuses on analyzing natural, plant-based medicine of indigenous cultures to help combat infectious disease and antibiotic resistance. In particular, she studies bacterial biofilm inhibition and quorum-sensing inhibition of botanical extracts for inflammatory skin conditions.
Iruka Okeke is a Nigerian microbiologist who studies the genetics of enteric disease-causing bacteria such as E. coli. She also researches ways to improve microbiology laboratory practices in Africa. She is a fellow of the Nigerian Academy of Sciences and the African Academy of Sciences.
A. C. Matin is an Indian-American microbiologist, immunologist, academician and researcher. He is a professor of microbiology and immunology at Stanford University School of Medicine.
Zehneria scabra is a perennial climbing or trailing herb that belong to the family Cucurbitaceae.
Pericopsis laxiflora is a woody deciduous shrub or tree within the Fabaceae family. Sold commercially as satin wood, it is known in some regions as Kulu Kulu, among the Hausa speaking people, it is called Makarfo, the Yorubas call it Ayan and the Igbos call it Abua-Ocha. It is one of three species in the genus Pericopsis genus that occurs in Africa.
References
- ↑ "10 Nigerian Women Pulling Their Weights In The Sciences". Leadership. November 10, 2017.
- ↑ "Stella Ifeanyi Smith". Google Scholar profile.
- ↑ "Stella Ifeanyi Smith" (PDF). NIMR.
- ↑ "Epidemiology of Shigellosis in Lagos, Nigeria: Trends in Antimicrobial Resistance". Center for Health and Population Research.
- ↑ "Antibacterial Effect of Edible Plant Extract on Escherichia coli 0157:H7" (PDF). Pakistan Journal on Nutrition.