Stereoelectronic effect

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In chemistry, primarily organic and computational chemistry, a stereoelectronic effect [1] is an effect on molecular geometry, reactivity, or physical properties due to spatial relationships in the molecules' electronic structure, in particular the interaction between atomic and/or molecular orbitals. [2] Phrased differently, stereoelectronic effects can also be defined as the geometric constraints placed on the ground and/or transition states of molecules that arise from considerations of orbital overlap. [3] Thus, a stereoelectronic effect explains a particular molecular property or reactivity by invoking stabilizing or destabilizing interactions that depend on the relative orientations of electrons (bonding or non-bonding) in space. [4]

Contents

Stereoelectronic effects present themselves in other well-known interactions. These include important phenomena such as the anomeric effect and hyperconjugation. It is important to note that stereoelectronic effects should not be misunderstood as a simple combination of steric effects and electronic effects.

Founded on a few general principles that govern how orbitals interact, the stereoelectronic effect, along with the steric effect, inductive effect, solvent effect, mesomeric effect, and aromaticity, is an important type of explanation for observed patterns of selectivity, reactivity, and stability in organic chemistry. In spite of the relatively straightforward premises, stereoelectronic effects often provide explanations for counterintuitive or surprising observations. As a result, stereoelectronic factors are now commonly considered and exploited in the development of new organic methodology and in the synthesis of complex targets. The scrutiny of stereoelectronic effects has also entered the realms of biochemistry and pharmaceutical chemistry in recent years.

A stereoelectronic effect generally involves a stabilizing donor-acceptor (i.e., filled bonding-empty antibonding, 2-electron 2-orbital) interaction. The donor is usually a higher bonding or nonbonding orbital and the acceptor is often a low-lying antibonding orbital as shown in the scheme below. Whenever possible, if this stereoelectronic effect is to be favored, the donor-acceptor orbitals should have (1) a small energy gap and (2) be geometrically well disposed for interaction. In particular, this means that the shapes of the donor and acceptor orbitals (including π or σ symmetry and size of the interacting lobes) must be well-matched for interaction; an antiperiplanar orientation is especially favorable. Some authors require stereoelectronic effects to be stabilizing. [1] However, destabilizing donor-donor (i.e., filled bonding-filled antibonding, 4-electron 2-orbital) interactions are occasionally invoked and are also sometimes referred to as stereoelectronic effects, although such effects are difficult to distinguish from generic steric repulsion. [3] [5]

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Trend of different orbitals

Take the simplest CH2X–CH3 system as an example; the donor orbital is σ(C–H) orbital and the acceptor is σ*(C–X). When moving from fluorine to chlorine, then to bromine, the electronegativity of the halogen and the energy level of the σ*(C–X) orbitals decreases. [6] Consequently, the general trend of acceptors can be summarized as: π*(C=O)>σ*(C–Hal)>σ*(C–O)>σ*(C–N)>σ*(C–C), σ*(C–H). For donating orbitals, the nonbonding orbitals, or the lone pairs, are generally more effective than bonding orbitals due to the high energy levels. Also, different from acceptors, donor orbitals require less polarized bonds. Thus, the general trends for donor orbitals would be: n(N)>n(O)>σ(C–C), σ(C–H)>σ(C–N)>σ(C–O)>σ(C–S)>σ(C–Hal). [5]

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Stereoelectronic effect can be directional in specific cases. The radius of sulfur is much larger than the radius of carbon and oxygen. Thus the differences in C–S bond distances generate a much-amplified difference in the two stereoelectronic effects in 1,3-dithiane (σ(C–H) → σ*(C–S)) than in 1,3-dioxane(σ(C–H) → σ*(C–O)). [6] The differences between C–C and C–S bonds shown below causes a significant difference in the distances between C–S and two C–H bonds. The shorter the difference is, the better the interaction and the stronger the stereoelectronic effect. [6]

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Influence on stability

If there is an electropositive substituent (e.g. –SiR3, –SnR3, –HgR, etc.) at the β-position of carbocation, the positive charge could be stabilized which is also due largely to the stereoelectronic effect (illustrated below using –SiR3 as an example). The orientation of the two interacting orbitals can have a significant effect on the stabilization effect (σ(C–Si) → empty p orbital), where antiperiplanar (180°) > perpendicular (90°) > syn (0°). [7]

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Influence on conformation

Gauche effect

One structural consequence of acyclic systems due to the stereoelectronic effect is the gauche effect. [8] In 1,2-difluoroethane, despite the steric clash, the preferred conformation is the gauche one because σ(C–H) is a good donor and σ*(C–F) is a good acceptor and the stereoelectronic effect (σ(C–H) → σ*(C–F)) requires the energy minimum to be gauche instead of anti. [9]

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This gauche effect and its impact on conformation are important in biochemistry. For example, in HIF-α subunit fragments containing (2S,4R)-4-hydroxyproline, the gauche interaction favors the conformer that can bind to the active site of pVHL. [10] pVHL mediates the proteasomal degradation of HIF1A and with that the physiological response to hypoxia.

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Special effects of fluorine substituent

Stereoelectronic effects can have a significant influence in pharmaceutical research. Generally, the substitution of hydrogen by fluorine could be regarded as a way to tune both the hydrophobicity and the metabolic stability of a drug candidate. Moreover, it can have a profound influence on conformations, often due to stereoelectronic effects, in addition to normal steric effects resulting from the larger size of the fluorine atom. For instance, the ground state geometries of anisole (methoxybenzene) and (trifluoromethoxy)benzene differ dramatically. In anisole, the methyl group prefers to be coplanar with the phenyl group, while (trifluoromethoxy)benzene favors a geometry in which the [C(aryl)–C(aryl)–O–C(F3)] dihedral angle is around 90°. In other words, the O–CF3 bond is perpendicular to the plane of the phenyl group. [11]

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Further studies illustrate that even for only one or two hydrogen atoms in a methyl group being replaced by a fluorine atom, the distortion in the structure can also be significant, with the [C(aryl)–C(aryl)–O–C(H2F)] dihedral angle in the energy minimized structure being around 24° and the [C(aryl)–C(aryl)–O–C(HF2)] dihedral angle 33°. [11]

Influence on reaction selectivity

Reductive cyclizations

Although the energy difference between coplanar anisole and its isomer is quite large, the rotation between the O–CH3 bond becomes favorable when the electronic properties of methoxy group on aromatic rings need to be altered to stabilize an unusual intermediate or a transition state. In the following reaction, the regioselectivity could be rationalized as the out-of-plane rotation of the O–C bond which changes the methoxy group from an in-plane donor group to an out-of-plane acceptor group. [12]

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The intermediate of the above reaction is the di-anion and the stereoelectronic effect that stabilizes this intermediate over the other one is the fact that the anionic charge at the para position could delocalize to the oxygen atom via orbital interaction: π(benzene) → σ*(O–CH3). [12]

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Hydrogenation

Even remote substituents on the benzene ring can affect the electron density on the aromatic ring and in turn influence the selectivity. In the hydrogenation of ketones using CBS catalysts, the ketone coordinates to the boron atom with the lone pair on the oxygen atom. In the following example, the inductive influence of the substituents can lead to differentiation of the two sp2 lone pairs on the oxygen atom. [13]

The relevant stereoelectronic interaction in the starting material is the nO → σ*(Ccarbonyl–Caryl) interaction. The electron-withdrawing substituent on the benzene ring depletes the electron density on the aromatic ring and thus makes the σ*(Ccarbonyl–Caryl(nitro)) orbital a better acceptor than σ*(Ccarbonyl–Caryl(methoxy)). These two stereoelectronic interactions use different lone pairs on the oxygen atom (the one antiperiplanar to the σ* in question for each), leading to lone pairs with different electron densities. In particular, the enhanced depletion of electron density from the lone pair antiperiplanar to the 4-nitrophenyl group leads to weakened ability for that lone pair to coordinate to boron. This in turn results in the lone pair antiperiplanar to the 4-methoxyphenyl binding preferentially to the catalyst, leading to well-defined facial selectivity. Under optimized conditions, the product is formed with excellent levels of enantioselectivity (95% ee). [13]

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Influence on thermodynamics

Influence on equilibrium

The stereoelectronic effect influences the thermodynamics of equilibrium. For example, the following equilibrium could be achieved via a cascade of pericyclic reactions.

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Despite very similar structures, one of the two isomers is strongly favored over the other because of a stereoelectronic effect. Since the σ*C-C orbital adjacent to the electron-withdrawing carbonyl group is lower in energy and is therefore a better acceptor than the σ*C-C orbital adjacent to the methoxy, the isomer in which the nO(σ) lone pair is able to donate into this lower-energy antibonding orbital will be stabilized (orbital interaction illustrated). [14]

Another example of the preference in the equilibrium within the area of pericyclic reaction is shown below. The stereoelectronic effect that affect the equilibrium is the interaction between the delocalized “banana bonds” and the empty p orbital on the boron atom. [15]

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Influence on resonance structures

In another case, the stereoelectronic effect can result in an increased contribution of one resonance structure over another, which leads to further consequences in reactivity. For 1,4-benzoquinone monoxime, there are significant differences in the physical properties and reactivities between C2-C3 double bond and C5-C6 double bond. For instance, in the 1H NMR, 3J23 higher than 3J56. [16] The C2-C3 double bond also selectively undergoes Diels–Alder reaction with cyclopentadiene, despite the increased steric hindrance on that side of the molecule. [17] These data illustrate an increased contribution of resonance structure B over structure A. The authors argue that the donation from nN to σ*C4-C3 orbital lengthens the C4–C3 bond (C4 is the carbon bearing the nitrogen substituent), which reduces the p-p overlap between these two atoms. This in turn decreasing the relative importance of structure A which has a double bond between C4 and C3. [18]

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Application in asymmetric Diels–Alder reactions

In the asymmetric Diels–Alder reactions, instead of using chiral ligands or chiral auxiliaries to differentiate the side selectivity of the dienolphiles, the differentiation of face selectivity of the dienes (especially for cyclopentadiene derivatives) using stereoelectronic effects have been reported by Woodward since 1955. [19] A systematic research of facial selectivity using substituted cyclopentadiene or permethylcyclopentadiene derivatives have been conducted and the results can be listed as below. [20]

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The stereoelectronic effect affecting the outcome of the facial selectivity of the diene in the Diels–Alder reaction is the interaction between the σ(C(sp2)–CH3) (when σ(C(sp2)–X) is a better acceptor than a donor) or σ(C(sp2)–X) (when σ(C(sp2)–X) is a better donor than an acceptor) and the σ* orbital of the forming bond between the diene and the dienophile. [20]

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If the two geminal substituents are both aromatic rings with different substituents tuning the electron density, the differentiation of the facial selectivity is also facile where the dienophile approaches the diene anti to the more electron-rich C–C bond where the stereoelectronic effect, in this case, is similar to the previous one. [21]

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The ring opening of cyclobutene under heating conditions can have two products: inward and outward rotation.

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The inward rotation transition state of the structure shown below is relatively favored for acceptor R substituents (e.g. NO2) but is especially disfavored by donor R substituents (e.g. NMe2). [22]

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Stereoelectronic effect versus steric clash

Sometimes, stereoelectronic effects can win over extreme steric clash. In a similar cyclobutene ring-opening reaction, the trimethylsilyl group, which is very bulky, still favors the inward rotation. The stereoelectronic effect, which is the interaction shown above when the acceptor orbital is the σ*(Si–CH3), appears to be a more predominant factor in determining the reaction selectivity against the steric hindrance and even wins over the penalty of the disrupted conjugation system of the product due to steric clash. [23]

Furthermore, the acceptor orbitals are not limited to the antibonding orbitals of carbon-heteroatom bonds or the empty orbitals; in the following case, the acceptor orbital is the σ*(B–O) orbital. In the six-membered ring transition state, the stereoelectronic interaction is σ(C–X) → σ*(B–O). [24]

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Stereoelectronic effects in biomolecules

Molecular recognition events mediated through orbital interactions are critical in a number of biological processes such as enzyme catalysis. [25] Stabilizing interactions between proteins and carbohydrates in glycosylated proteins also exemplify the role of stereoelectronic effects in biomolecules. [26]

Related Research Articles

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In theoretical chemistry, a conjugated system is a system of connected p-orbitals with delocalized electrons in a molecule, which in general lowers the overall energy of the molecule and increases stability. It is conventionally represented as having alternating single and multiple bonds. Lone pairs, radicals or carbenium ions may be part of the system, which may be cyclic, acyclic, linear or mixed. The term "conjugated" was coined in 1899 by the German chemist Johannes Thiele.

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The 1,3-dipolar cycloaddition is a chemical reaction between a 1,3-dipole and a dipolarophile to form a five-membered ring. The earliest 1,3-dipolar cycloadditions were described in the late 19th century to the early 20th century, following the discovery of 1,3-dipoles. Mechanistic investigation and synthetic application were established in the 1960s, primarily through the work of Rolf Huisgen. Hence, the reaction is sometimes referred to as the Huisgen cycloaddition. 1,3-dipolar cycloaddition is an important route to the regio- and stereoselective synthesis of five-membered heterocycles and their ring-opened acyclic derivatives. The dipolarophile is typically an alkene or alkyne, but can be other pi systems. When the dipolarophile is an alkyne, aromatic rings are generally produced.

The Baeyer–Villiger oxidation is an organic reaction that forms an ester from a ketone or a lactone from a cyclic ketone, using peroxyacids or peroxides as the oxidant. The reaction is named after Adolf von Baeyer and Victor Villiger who first reported the reaction in 1899.

<span class="mw-page-title-main">Hyperconjugation</span> Concept in organic chemistry

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<span class="mw-page-title-main">Bent's rule</span> Rule in geometry of individual molecules

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<span class="mw-page-title-main">Oxocarbenium</span>

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<span class="mw-page-title-main">Digermyne</span> Class of chemical compounds

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Bismuthinidenes are a class of organobismuth compounds, analogous to carbenes. These compounds have the general form R-Bi, with two lone pairs of electrons on the central bismuth(I) atom. Due to the unusually low valency and oxidation state of +1, most bismuthinidenes are reactive and unstable, though in recent decades, both transition metals and polydentate chelating Lewis base ligands have been employed to stabilize the low-valent bismuth(I) center through steric protection and π donation either in solution or in crystal structures. Lewis base-stabilized bismuthinidenes adopt a singlet ground state with an inert lone pair of electrons in the 6s orbital. A second lone pair in a 6p orbital and a single empty 6p orbital make Lewis base-stabilized bismuthinidenes ambiphilic.

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References

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  2. ↑ Cramer, Christopher J. (1996). "Hyperconjugation as it affects conformational analysis". Journal of Molecular Structure: THEOCHEM. 370 (2–3): 135–146. doi:10.1016/S0166-1280(96)04567-8. ISSN   0166-1280.
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  21. ↑ Halterman, R. L.; McCarthy, B. A.; McEvoy, M. A. (1992). "Stereoelectronic control of facial selectivity in the Diels-Alder cycloaddition of sterically unbiased 5,5-diarylcyclopentadienes". J. Org. Chem. 57 (21): 5585–5589. doi:10.1021/jo00047a009.
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  23. ↑ Murakami, M.; Hasegawa, M. (2004). "Synthesis and Thermal Ring Opening oftrans-3,4-Disilylcyclobutene". Angew. Chem. Int. Ed. 43 (37): 4874–4876. doi:10.1002/anie.200460144. PMID   15372640.
  24. ↑ Schlapbach, A.; Hoffmann, R. W. (2001). "(E)-α-Sulfonamidocrotylboronates as Reagents for the Stereoselective Homoaldol Synthesis". J. Org. Chem. 66 (2): 323–328. doi:10.1002/1099-0690(200101)2001:2<323::aid-ejoc323>3.0.co;2-a.
  25. ↑ Gorenstein, David G. (1987-10-01). "Stereoelectronic effects in biomolecules". Chemical Reviews. 87 (5): 1047–1077. doi:10.1021/cr00081a009. ISSN   0009-2665.
  26. ↑ Ardejani, Maziar S.; Noodleman, Louis; Powers, Evan T.; Kelly, Jeffery W. (2021-03-15). "Stereoelectronic effects in stabilizing protein– N -glycan interactions revealed by experiment and machine learning". Nature Chemistry. 13 (5): 480–487. Bibcode:2021NatCh..13..480A. doi:10.1038/s41557-021-00646-w. ISSN   1755-4349. PMC   8102341 . PMID   33723379.
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