Study of Transition, Outcomes, and Gender

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The Study of Transition, Outcomes, and Gender (STRONG) is a cohort study of health in transgender people before and during or after gender-affirming treatments such as gender-affirming hormone therapy and gender-affirming surgery. [1] It is being conducted at Kaiser Permanente sites in Northern California, Southern California, and Georgia and includes over 6,000 transgender people. [1] The study was underway by 2015 [2] and the first paper for the study was published in 2017. [1] The STRONG cohort represents the largest cohort of transgender people studied to date and the first such large-scale study conducted in the United States. [2]

STRONG has published papers assessing transgender population size and demographics, [3] agreement between electronic medical records and self-reported gender identity, [4] gender dysphoria and mental health, [5] [6] suicidality, [7] "passing" and mental health, [8] progression of gender dysphoria in transgender youth, [9] hematological parameters, [10] liver parameters, [11] acne risk, [12] [13] psoriasis risk, [14] cardiovascular health, [15] [16] diabetes risk, [17] [18] and cancer risk. [19]

See also

References

  1. 1 2 3 Quinn VP, Nash R, Hunkeler E, Contreras R, Cromwell L, Becerra-Culqui TA, Getahun D, Giammattei S, Lash TL, Millman A, Robinson B, Roblin D, Silverberg MJ, Slovis J, Tangpricha V, Tolsma D, Valentine C, Ward K, Winter S, Goodman M (December 2017). "Cohort profile: Study of Transition, Outcomes and Gender (STRONG) to assess health status of transgender people". BMJ Open. 7 (12): e018121. doi:10.1136/bmjopen-2017-018121. PMC   5770907 . PMID   29284718.
  2. 1 2 Quinn VP, Becerra TA, Gillespie T, Hunkeler E, Baird T, Baisch NM, Owen-Smith A, Roblin D, Stephenson R, Tangpricha V, Valentine C, Goodman M. Embedding Patients, Providers, and Community Stakeholders in Research to Improve Transgender Health. J Patient Cent Res Rev 2015;2:114–115. http://dx.doi.org/10.17294/2330-0698.1137
  3. ↑ Zhang Q, Rechler W, Bradlyn A, Flanders WD, Getahun D, Lash TL, McCracken C, Nash R, Panagiotakopoulos L, Roblin D, Sandberg DE, Silverberg MJ, Tangpricha V, Vupputuri S, Goodman M (May 2021). "Changes in Size and Demographic Composition of Transgender and Gender Non-Binary Population Receiving Care at Integrated Health Systems". Endocr Pract. 27 (5): 390–395. doi:10.1016/j.eprac.2020.11.016. PMID   33678315. S2CID   232140899.
  4. ↑ Gerth J, Becerra-Culqui T, Bradlyn A, Getahun D, Hunkeler EM, Lash TL, Millman A, Nash R, Quinn VP, Robinson B, Roblin D, Silverberg MJ, Tangpricha V, Vupputuri S, Goodman M (September 2018). "Agreement between medical records and self-reports: Implications for transgender health research". Rev Endocr Metab Disord. 19 (3): 263–269. doi:10.1007/s11154-018-9461-4. PMC   6438197 . PMID   30219985.
  5. ↑ Owen-Smith AA, Gerth J, Sineath RC, Barzilay J, Becerra-Culqui TA, Getahun D, Giammattei S, Hunkeler E, Lash TL, Millman A, Nash R, Quinn VP, Robinson B, Roblin D, Sanchez T, Silverberg MJ, Tangpricha V, Valentine C, Winter S, Woodyatt C, Song Y, Goodman M (April 2018). "Association Between Gender Confirmation Treatments and Perceived Gender Congruence, Body Image Satisfaction, and Mental Health in a Cohort of Transgender Individuals". J Sex Med. 15 (4): 591–600. doi:10.1016/j.jsxm.2018.01.017. PMC   5882508 . PMID   29463478.
  6. ↑ Becerra-Culqui TA, Liu Y, Nash R, Cromwell L, Flanders WD, Getahun D, Giammattei SV, Hunkeler EM, Lash TL, Millman A, Quinn VP, Robinson B, Roblin D, Sandberg DE, Silverberg MJ, Tangpricha V, Goodman M (May 2018). "Mental Health of Transgender and Gender Nonconforming Youth Compared With Their Peers". Pediatrics. 141 (5). doi:10.1542/peds.2017-3845. PMC   5914494 . PMID   29661941.
  7. ↑ Mak J, Shires DA, Zhang Q, Prieto LR, Ahmedani BK, Kattari L, Becerra-Culqui TA, Bradlyn A, Flanders WD, Getahun D, Giammattei SV, Hunkeler EM, Lash TL, Nash R, Quinn VP, Robinson B, Roblin D, Silverberg MJ, Slovis J, Tangpricha V, Vupputuri S, Goodman M (October 2020). "Suicide Attempts Among a Cohort of Transgender and Gender Diverse People". Am J Prev Med. 59 (4): 570–577. doi:10.1016/j.amepre.2020.03.026. PMC   7508867 . PMID   32798005.
  8. ↑ To M, Zhang Q, Bradlyn A, Getahun D, Giammattei S, Nash R, Owen-Smith AA, Roblin D, Silverberg MJ, Tangpricha V, Vupputuri S, Goodman M (October 2020). "Visual Conformity With Affirmed Gender or "Passing": Its Distribution and Association With Depression and Anxiety in a Cohort of Transgender People". J Sex Med. 17 (10): 2084–2092. doi:10.1016/j.jsxm.2020.07.019. PMC   7529975 . PMID   32807706.
  9. ↑ Wagner S, Panagiotakopoulos L, Nash R, Bradlyn A, Getahun D, Lash TL, Roblin D, Silverberg MJ, Tangpricha V, Vupputuri S, Goodman M (July 2021). "Progression of Gender Dysphoria in Children and Adolescents: A Longitudinal Study". Pediatrics. 148 (1). doi:10.1542/peds.2020-027722. PMC   8276590 . PMID   34099504.
  10. ↑ Antun A, Zhang Q, Bhasin S, Bradlyn A, Flanders WD, Getahun D, Lash TL, Nash R, Roblin D, Silverberg MJ, Tangpricha V, Vupputuri S, Goodman M (November 2020). "Longitudinal Changes in Hematologic Parameters Among Transgender People Receiving Hormone Therapy". J Endocr Soc. 4 (11): bvaa119. doi: 10.1210/jendso/bvaa119 . PMC   8011434 . PMID   33834151.
  11. ↑ Hashemi L, Zhang Q, Getahun D, Jasuja GK, McCracken C, Pisegna J, Roblin D, Silverberg MJ, Tangpricha V, Vupputuri S, Goodman M (September 2021). "Longitudinal Changes in Liver Enzyme Levels Among Transgender People Receiving Gender Affirming Hormone Therapy". J Sex Med. 18 (9): 1662–1675. doi:10.1016/j.jsxm.2021.06.011. PMC   8444147 . PMID   34366264.
  12. ↑ Yeung H, Ragmanauskaite L, Zhang Q, Kim J, Tangpricha V, Getahun D, Silverberg MJ, Goodman M (November 2020). "Prevalence of moderate to severe acne in transgender adults: A cross-sectional survey". J Am Acad Dermatol. 83 (5): 1450–1452. doi:10.1016/j.jaad.2020.02.053. PMC   7483412 . PMID   32109538.
  13. ↑ Braun H, Zhang Q, Getahun D, Silverberg MJ, Tangpricha V, Goodman M, Yeung H (March 2021). "Moderate-to-Severe Acne and Mental Health Symptoms in Transmasculine Persons Who Have Received Testosterone". JAMA Dermatol. 157 (3): 344–346. doi:10.1001/jamadermatol.2020.5353. PMC   7970332 . PMID   33471032.
  14. ↑ Braun H, Thompson EC, Zhang Q, Tangpricha V, Goodman M, Yeung H (28 March 2022). "Prevalence of Psoriasis and Perceived Association with Hormone Therapy in Transgender Adults". Transgender Health. 8 (4): 396–399. doi:10.1089/trgh.2021.0104. eISSN   2380-193X. ISSN   2688-4887. PMC   10387154 . PMID   37525834. S2CID   247823888.
  15. ↑ Getahun D, Nash R, Flanders WD, Baird TC, Becerra-Culqui TA, Cromwell L, Hunkeler E, Lash TL, Millman A, Quinn VP, Robinson B, Roblin D, Silverberg MJ, Safer J, Slovis J, Tangpricha V, Goodman M (August 2018). "Cross-sex Hormones and Acute Cardiovascular Events in Transgender Persons: A Cohort Study". Ann Intern Med. 169 (4): 205–213. doi:10.7326/M17-2785. PMC   6636681 . PMID   29987313.
  16. ↑ Goodman M, Getahun D, Silverberg MJ, Safer J, Tangpricha V (January 2019). "Cross-Sex Hormones and Acute Cardiovascular Events in Transgender Persons". Ann Intern Med. 170 (2): 143. doi:10.7326/L18-0564. PMID   30641565. S2CID   58004787.
  17. ↑ Islam N, Nash R, Zhang Q, Panagiotakopoulos L, Daley T, Bhasin S, Getahun D, Sonya Haw J, McCracken C, Silverberg MJ, Tangpricha V, Vupputuri S, Goodman M (March 2022). "Is There a Link Between Hormone Use and Diabetes Incidence in Transgender People? Data From the STRONG Cohort". J Clin Endocrinol Metab. 107 (4): e1549 –e1557. doi:10.1210/clinem/dgab832. PMC   8947226 . PMID   34850912.
  18. ↑ Tangpricha V (May 2022). "Gender-affirming Hormone Therapy and Risk of Diabetes in Transgender Persons". J Clin Endocrinol Metab. 107 (6): e2632 –e2633. doi:10.1210/clinem/dgac060. PMC   9113784 . PMID   35106582.
  19. ↑ Silverberg MJ, Nash R, Becerra-Culqui TA, Cromwell L, Getahun D, Hunkeler E, Lash TL, Millman A, Quinn VP, Robinson B, Roblin D, Slovis J, Tangpricha V, Goodman M (August 2017). "Cohort study of cancer risk among insured transgender people". Ann Epidemiol. 27 (8): 499–501. doi:10.1016/j.annepidem.2017.07.007. PMID   28780974.
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