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A synthetic radioisotope is a radionuclide that is not found in nature: no natural process or mechanism exists which produces it, or it is so unstable that it decays away in a very short period of time. Examples include technetium-99 and promethium-146. Many of these are found in, and harvested from, spent nuclear fuel assemblies. Some must be manufactured in particle accelerators. [1]
Some synthetic radioisotopes are extracted from spent nuclear reactor fuel rods, which contain various fission products. For example, it is estimated that up to 1994, about 49,000 terabecquerels (78 metric tons) of technetium were produced in nuclear reactors; as such, anthropogenic technetium is far more abundant than technetium from natural radioactivity. [2]
Some synthetic isotopes are produced in significant quantities by fission but are not yet being reclaimed. Other isotopes are manufactured by neutron irradiation of parent isotopes in a nuclear reactor (for example, technetium-97 can be made by neutron irradiation of ruthenium-96) or by bombarding parent isotopes with high energy particles from a particle accelerator. [3] [4]
Many isotopes, including radiopharmaceuticals, are produced in cyclotrons. For example, the synthetic fluorine-18 and oxygen-15 are widely used in positron emission tomography. [5]
Most synthetic radioisotopes have a short half-life. Though a health hazard, radioactive materials have many medical and industrial uses.
The field of nuclear medicine covers use of radioisotopes for diagnosis or treatment.
Radioactive tracer compounds, radiopharmaceuticals, are used to observe the function of various organs and body systems. These compounds use a chemical tracer which is attracted to or concentrated by the activity which is being studied. That chemical tracer incorporates a short lived radioactive isotope, usually one which emits a gamma ray which is energetic enough to travel through the body and be captured outside by a gamma camera to map the concentrations. Gamma cameras and other similar detectors are highly efficient, and the tracer compounds are generally very effective at concentrating at the areas of interest, so the total amounts of radioactive material needed are very small.
The metastable nuclear isomer technetium-99m is a gamma-ray emitter widely used for medical diagnostics because it has a short half-life of 6 hours, but can be easily made in the hospital using a technetium-99m generator. Weekly global demand for the parent isotope molybdenum-99 was 440 TBq (12,000 Ci ) in 2010, overwhelmingly provided by fission of uranium-235. [6]
Several radioisotopes and compounds are used for medical treatment, usually by bringing the radioactive isotope to a high concentration in the body near a particular organ. For example, iodine-131 is used for treating some disorders and tumors of the thyroid gland.
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Alpha particle, beta particle, and gamma ray radioactive emissions are industrially useful. Most sources of these are synthetic radioisotopes. Areas of use include the petroleum industry, industrial radiography, homeland security, process control, food irradiation and underground detection. [7] [8] [9]
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Neutron activation analysis (NAA) is a nuclear process used for determining the concentrations of elements in many materials. NAA allows discrete sampling of elements as it disregards the chemical form of a sample, and focuses solely on atomic nuclei. The method is based on neutron activation and thus requires a neutron source. The sample is bombarded with neutrons, causing its constituent elements to form radioactive isotopes. The radioactive emissions and radioactive decay paths for each element have long been studied and determined. Using this information, it is possible to study spectra of the emissions of the radioactive sample, and determine the concentrations of the various elements within it. A particular advantage of this technique is that it does not destroy the sample, and thus has been used for the analysis of works of art and historical artifacts. NAA can also be used to determine the activity of a radioactive sample.
Technetium is a chemical element; it has symbol Tc and atomic number 43. It is the lightest element whose isotopes are all radioactive. Technetium and promethium are the only radioactive elements whose neighbours in the sense of atomic number are both stable. All available technetium is produced as a synthetic element. Naturally occurring technetium is a spontaneous fission product in uranium ore and thorium ore, or the product of neutron capture in molybdenum ores. This silvery gray, crystalline transition metal lies between manganese and rhenium in group 7 of the periodic table, and its chemical properties are intermediate between those of both adjacent elements. The most common naturally occurring isotope is 99Tc, in traces only.
A radionuclide (radioactive nuclide, radioisotope or radioactive isotope) is a nuclide that has excess numbers of either neutrons or protons, giving it excess nuclear energy, and making it unstable. This excess energy can be used in one of three ways: emitted from the nucleus as gamma radiation; transferred to one of its electrons to release it as a conversion electron; or used to create and emit a new particle (alpha particle or beta particle) from the nucleus. During those processes, the radionuclide is said to undergo radioactive decay. These emissions are considered ionizing radiation because they are energetic enough to liberate an electron from another atom. The radioactive decay can produce a stable nuclide or will sometimes produce a new unstable radionuclide which may undergo further decay. Radioactive decay is a random process at the level of single atoms: it is impossible to predict when one particular atom will decay. However, for a collection of atoms of a single nuclide the decay rate, and thus the half-life (t1/2) for that collection, can be calculated from their measured decay constants. The range of the half-lives of radioactive atoms has no known limits and spans a time range of over 55 orders of magnitude.
Nuclear chemistry is the sub-field of chemistry dealing with radioactivity, nuclear processes, and transformations in the nuclei of atoms, such as nuclear transmutation and nuclear properties.
Single-photon emission computed tomography is a nuclear medicine tomographic imaging technique using gamma rays. It is very similar to conventional nuclear medicine planar imaging using a gamma camera, but is able to provide true 3D information. This information is typically presented as cross-sectional slices through the patient, but can be freely reformatted or manipulated as required.
Nuclear medicine or nucleology is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease. Nuclear imaging, in a sense, is "radiology done inside out" because it records radiation emitted from within the body rather than radiation that is transmitted through the body from external sources like X-ray generators. In addition, nuclear medicine scans differ from radiology, as the emphasis is not on imaging anatomy, but on the function. For such reason, it is called a physiological imaging modality. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) scans are the two most common imaging modalities in nuclear medicine.
A radioactive tracer, radiotracer, or radioactive label is a synthetic derivative of a natural compound in which one or more atoms have been replaced by a radionuclide. By virtue of its radioactive decay, it can be used to explore the mechanism of chemical reactions by tracing the path that the radioisotope follows from reactants to products. Radiolabeling or radiotracing is thus the radioactive form of isotopic labeling. In biological contexts, experiments that use radioisotope tracers are sometimes called radioisotope feeding experiments.
Radiopharmacology is radiochemistry applied to medicine and thus the pharmacology of radiopharmaceuticals. Radiopharmaceuticals are used in the field of nuclear medicine as radioactive tracers in medical imaging and in therapy for many diseases. Many radiopharmaceuticals use technetium-99m (Tc-99m) which has many useful properties as a gamma-emitting tracer nuclide. In the book Technetium a total of 31 different radiopharmaceuticals based on Tc-99m are listed for imaging and functional studies of the brain, myocardium, thyroid, lungs, liver, gallbladder, kidneys, skeleton, blood and tumors.
Neutron activation is the process in which neutron radiation induces radioactivity in materials, and occurs when atomic nuclei capture free neutrons, becoming heavier and entering excited states. The excited nucleus decays immediately by emitting gamma rays, or particles such as beta particles, alpha particles, fission products, and neutrons. Thus, the process of neutron capture, even after any intermediate decay, often results in the formation of an unstable activation product. Such radioactive nuclei can exhibit half-lives ranging from small fractions of a second to many years.
A technetium-99m generator, or colloquially a technetium cow or moly cow, is a device used to extract the metastable isotope 99mTc of technetium from a decaying sample of molybdenum-99. 99Mo has a half-life of 66 hours and can be easily transported over long distances to hospitals where its decay product technetium-99m is extracted and used for a variety of nuclear medicine diagnostic procedures, where its short half-life is very useful.
The pertechnetate ion is an oxyanion with the chemical formula TcO−
4. It is often used as a convenient water-soluble source of isotopes of the radioactive element technetium (Tc). In particular it is used to carry the 99mTc isotope which is commonly used in nuclear medicine in several nuclear scanning procedures.
There are 37 known isotopes of iodine (53I) from 108I to 144I; all undergo radioactive decay except 127I, which is stable. Iodine is thus a monoisotopic element.
Technetium (43Tc) is one of the two elements with Z < 83 that have no stable isotopes; the other such element is promethium. It is primarily artificial, with only trace quantities existing in nature produced by spontaneous fission or neutron capture by molybdenum. The first isotopes to be synthesized were 97Tc and 99Tc in 1936, the first artificial element to be produced. The most stable radioisotopes are 97Tc, 98Tc, and 99Tc.
Molybdenum (42Mo) has 39 known isotopes, ranging in atomic mass from 81 to 119, as well as four metastable nuclear isomers. Seven isotopes occur naturally, with atomic masses of 92, 94, 95, 96, 97, 98, and 100. All unstable isotopes of molybdenum decay into isotopes of zirconium, niobium, technetium, and ruthenium.
Naturally occurring zirconium (40Zr) is composed of four stable isotopes (of which one may in the future be found radioactive), and one very long-lived radioisotope (96Zr), a primordial nuclide that decays via double beta decay with an observed half-life of 2.0×1019 years; it can also undergo single beta decay, which is not yet observed, but the theoretically predicted value of t1/2 is 2.4×1020 years. The second most stable radioisotope is 93Zr, which has a half-life of 1.53 million years. Thirty other radioisotopes have been observed. All have half-lives less than a day except for 95Zr (64.02 days), 88Zr (83.4 days), and 89Zr (78.41 hours). The primary decay mode is electron capture for isotopes lighter than 92Zr, and the primary mode for heavier isotopes is beta decay.
Radionuclides which emit gamma radiation are valuable in a range of different industrial, scientific and medical technologies. This article lists some common gamma-emitting radionuclides of technological importance, and their properties.
This page discusses each of the main elements in the mixture of fission products produced by nuclear fission of the common nuclear fuels uranium and plutonium. The isotopes are listed by element, in order by atomic number.
Technetium-99m (99mTc) is a metastable nuclear isomer of technetium-99, symbolized as 99mTc, that is used in tens of millions of medical diagnostic procedures annually, making it the most commonly used medical radioisotope in the world.
Radiopharmaceuticals, or medicinal radiocompounds, are a group of pharmaceutical drugs containing radioactive isotopes. Radiopharmaceuticals can be used as diagnostic and therapeutic agents. Radiopharmaceuticals emit radiation themselves, which is different from contrast media which absorb or alter external electromagnetism or ultrasound. Radiopharmacology is the branch of pharmacology that specializes in these agents.
Radioisotopes Production Facility (RPF), is a facility for the production of radioisotopes from irradiation of Low enriched uranium (LEU) in the Egyptian Second Research Reactor (ETRR-2) Complex. The RPF was supplied by the Argentine company Investigacion Aplicada (INVAP) and was commissioned during October and November 2011. The produced radioisotopes are used in medicine, industry and research activities for domestic market.