TAOK3

TAOK3
Identifiers
Aliases	TAOK3 , DPK, JIK, MAP3K18, TAO kinase 3, hKFC-A
External IDs	OMIM: 616711 MGI: 3041177 HomoloGene: 83279 GeneCards: TAOK3
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.23 Start 118,149,801 bp [1] End 118,372,907 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 117,258,194 bp [2] End 117,413,284 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte jejunal mucosa bone marrow cells superior vestibular nucleus middle temporal gyrus external globus pallidus internal globus pallidus corpus callosum inferior ganglion of vagus nerve Top expressed in crypt of lieberkuhn of small intestine ventromedial nucleus supraoptic nucleus conjunctival fornix epithelium of stomach mammillary body retinal pigment epithelium lateral hypothalamus left lung lobe right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein kinase inhibitor activity kinase activity protein serine/threonine kinase activity protein binding ATP binding MAP kinase kinase kinase activity Cellular component cytoplasm membrane plasma membrane nucleus Biological process phosphorylation positive regulation of JUN kinase activity positive regulation of JNK cascade MAPK cascade cellular response to DNA damage stimulus negative regulation of JNK cascade protein phosphorylation protein autophosphorylation mitotic G2 DNA damage checkpoint signaling DNA repair positive regulation of stress-activated MAPK cascade negative regulation of protein kinase activity nervous system development regulation of apoptotic process signal transduction stress-activated protein kinase signaling cascade activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51347 330177 Ensembl ENSG00000135090 ENSMUSG00000061288 UniProt Q9H2K8 Q8BYC6 RefSeq (mRNA) NM_001346487 NM_001346488 NM_001346489 NM_001346490 NM_001346491 NM_001346492 NM_001346493 NM_001346494 NM_001346495 NM_001346496 NM_001346497 NM_016281 NM_001081308 NM_001199685 NM_183306 RefSeq (protein) NP_001333416 NP_001333417 NP_001333418 NP_001333419 NP_001333420 NP_001333421 NP_001333422 NP_001333423 NP_001333424 NP_001333425 NP_001333426 NP_057365 NP_001074777 NP_001186614 NP_899129 Location (UCSC) Chr 12: 118.15 – 118.37 Mb Chr 5: 117.26 – 117.41 Mb PubMed search [3] [4]
Wikidata
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Serine/threonine-protein kinase TAO3 is an enzyme that in humans is encoded by the TAOK3 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000135090 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061288 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tassi E, Biesova Z, Di Fiore PP, Gutkind JS, Wong WT (Dec 1999). "Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor". J Biol Chem. 274 (47): 33287–95. doi: 10.1074/jbc.274.47.33287 . PMID   10559204.
6. Zhang W, Chen T, Wan T, He L, Li N, Yuan Z, Cao X (Sep 2000). "Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways". Biochem Biophys Res Commun. 274 (3): 872–9. doi:10.1006/bbrc.2000.3244. PMID   10924369.
7. "Entrez Gene: TAOK3 TAO kinase 3".

Further reading

• Yoneda T, Imaizumi K, Oono K, et al. (2001). "Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress". J. Biol. Chem. 276 (17): 13935–40. doi: 10.1074/jbc.M010677200 . PMID   11278723.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Yustein JT, Xia L, Kahlenburg JM, et al. (2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38". Oncogene. 22 (40): 6129–41. doi:10.1038/sj.onc.1206605. PMID   13679851.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Hartmann TB, Thiel D, Dummer R, et al. (2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". Br. J. Dermatol. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID   14996095. S2CID   42495130.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.