TBC1D3

TBC1D3F
Identifiers
Aliases	TBC1D3F , TBC1D3, TBC1D3G, TBC1 domain family member 3F
External IDs	OMIM: 610809; HomoloGene: 74280; GeneCards: TBC1D3F; OMA:TBC1D3F - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q12 Start 36,428,618 bp [1] End 36,439,566 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle right testis left testis right uterine tube left uterine tube bone marrow duodenum skeletal muscle tissue gallbladder blood n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity Cellular component membrane plasma membrane intracellular anatomical structure endomembrane system Biological process intracellular protein transport regulation of vesicle fusion activation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84218 n/a Ensembl ENSG00000275954 n/a UniProt A6NER0 n/a RefSeq (mRNA) NM_032258 n/a RefSeq (protein) NP_115634 n/a Location (UCSC) Chr 17: 36.43 – 36.44 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

TBC1 domain family member 3E/3F is a protein that in humans is encoded by the TBC1D3F gene. ^{[3] [4]}

This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in Rab GTPase signaling and vesicle trafficking. There are two copies of this gene located within a cluster of chemokine genes on chromosome 17q; this record represents the more centromeric copy. ^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000275954 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Hodzic D, Kong C, Wainszelbaum MJ, Charron AJ, Su X, Stahl PD (Nov 2006). "TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12". Genomics. 88 (6): 731–6. doi:10.1016/j.ygeno.2006.05.009. PMID   16863688.
4. "Entrez Gene: TBC1D3 TBC1 domain family, member 3".

Further reading

• Onno M, Nakamura T, Hillova J, Hill M (1993). "Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes". Gene. 131 (2): 209–15. doi:10.1016/0378-1119(93)90295-E. PMID   8406013.
• Onno M, Nakamura T, Mariage-Samson R, et al. (1993). "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes". DNA Cell Biol. 12 (2): 107–18. doi:10.1089/dna.1993.12.107. PMID   8471161.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Paulding CA, Ruvolo M, Haber DA (2003). "The Tre2 (USP6) oncogene is a hominoid-specific gene". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2507–11. Bibcode:2003PNAS..100.2507P. doi: 10.1073/pnas.0437015100 . PMC   151371 . PMID   12604796.
• Masuda-Robens JM, Kutney SN, Qi H, Chou MM (2003). "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling". Mol. Cell. Biol. 23 (6): 2151–61. doi:10.1128/MCB.23.6.2151-2161.2003. PMC   149457 . PMID   12612085.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.