TCF7L1

TCF7L1
Identifiers
Aliases	TCF7L1 , TCF-3, TCF3, transcription factor 7 like 1
External IDs	OMIM: 604652 MGI: 1202876 HomoloGene: 7563 GeneCards: TCF7L1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,310,387 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,766,237 bp
RNA expression pattern
	Top expressed in
	popliteal artery; ; gastric mucosa; ; ascending aorta; ; subcutaneous adipose tissue; ; left lobe of thyroid gland; ; canal of the cervix; ; right lobe of thyroid gland; ; right coronary artery; ; left coronary artery; ; sural nerve;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; vas deferens; ; left colon; ; ankle joint; ; abdominal wall; ; ciliary body; ; dermis; ; molar; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding ; beta-catenin binding ; DNA binding ; DNA-binding transcription factor activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ; chromatin binding ;
Cellular component	transcription regulator complex ; nucleus ; nucleoplasm ; cytosol ;
Biological process	regulation of Wnt signaling pathway ; chromatin organization ; Wnt signaling pathway ; transcription, DNA-templated ; canonical Wnt signaling pathway ; regulation of transcription by RNA polymerase II ; regulation of transcription, DNA-templated ; beta-catenin-TCF complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	83439
	21415
	ENSG00000152284
	ENSMUSG00000055799
	Q9HCS4
	Q9Z1J1
	NM_031283
	NM_001079822 ; NM_009332
	NP_112573
	NP_001073290 ; NP_033358
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Transcription factor 7-like 1, also known as TCF7L1, is a human gene.^[5]

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.^[5]

Model organisms

*Tcf7l1* knockout mouse phenotype
Characteristic	Phenotype
Homozygote viability	Abnormal
Recessive lethal study	Abnormal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Skin Histopathology	Normal
Salmonella infection	Normal^[6]
Citrobacter infection	Normal^[7]
All tests and analysis from^[8]^[9]

Model organisms have been used in the study of TCF7L1 function. A conditional knockout mouse line, called Tcf7l1^{tm1a(EUCOMM)Wtsi}^[10]^[11] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[12]^[13]^[14]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[8]^[15] Twenty four tests were carried out on mutant mice and two significant abnormalities were observed.^[8] Few homozygous mutant embryos were identified during gestation, and those that did survive had a severe craniofacial defect. None survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.^[8]

Related Research Articles

The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt is a portmanteau created from the names Wingless and Int-1. Wnt signaling pathways use either nearby cell-cell communication (paracrine) or same-cell communication (autocrine). They are highly evolutionarily conserved in animals, which means they are similar across animal species from fruit flies to humans.

Catenin beta-1, also known as beta-catenin (β-catenin), is a protein that in humans is encoded by the CTNNB1 gene.

BMP and activin membrane-bound inhibitor homolog , also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.

Transcription factor 7-like 2 , also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. The TCF7L2 gene is located on chromosome 10q25.2–q25.3, contains 19 exons. As a member of the TCF family, TCF7L2 can form a bipartite transcription factor and influence several biological pathways, including the Wnt signalling pathway.

Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene.

Axin-1 is a protein that in humans is encoded by the AXIN1 gene.

Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene. It's a member of T cell factor/lymphoid enhancer factor (TCF/LEF) family.

Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 gene.

Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene.

Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene.

Protein Wnt-3a is a protein that in humans is encoded by the WNT3A gene.

Axin-2 also known as axin-like protein (Axil) or axis inhibition protein 2 (AXIN2) or conductin is a protein that in humans is encoded by the AXIN2 gene.

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.

Pygopus homolog 2 is a protein that in humans is encoded by the PYGO2 gene.

B-cell CLL/lymphoma 9 protein is a protein that in humans is encoded by the BCL9 gene.

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.

The TCF/LEF family is a group of genes that encode transcription factors which bind to DNA through a SOX-like high mobility group domain. They are involved in the Wnt signaling pathway, particularly during embryonic and stem-cell development, but also had been found to play a role in cancer and diabetes. TCF/LEF factors recruit the coactivator beta-catenin to enhancer elements of genes they target. They can also recruit members of the Groucho family of corepressors.

SRY-box 7 is a protein that in humans is encoded by the SOX7 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152284 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055799 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "TCF7L1 transcription factor 7 like 1 [ Homo sapiens (human) ]" . Retrieved 2021-05-29.
↑ "Salmonella infection data for Tcf7l1". Wellcome Trust Sanger Institute.
↑ "Citrobacter infection data for Tcf7l1". Wellcome Trust Sanger Institute.
1 2 3 4 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
↑ "International Knockout Mouse Consortium".
↑ "Mouse Genome Informatics".
↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410 . PMID 21677750.
↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi: 10.1038/474262a . PMID 21677718.
↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018 . PMID 17218247. S2CID 18872015.
↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837 . PMID 21722353.

Castrop J, van Norren K, Clevers H (Feb 1992). "A gene family of HMG-box transcription factors with homology to TCF-1". Nucleic Acids Research. 20 (3): 611. doi:10.1093/nar/20.3.611. PMC 310434 . PMID 1741298.
Sagara N, Katoh M (Nov 2000). "Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation". Cancer Research. 60 (21): 5959–62. PMID 11085512.
Kim TW, Kim HJ, Lee C, Kim HY, Baek SH, Kim JH, Kwon KS, Kim JR (Apr 2008). "Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system". Experimental Gerontology. 43 (4): 286–95. doi:10.1016/j.exger.2007.12.010. PMID 18258400. S2CID 37034259.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464 . PMID 20379614.
Katoh M (Jan 2007). "Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis". Stem Cell Reviews. 3 (1): 30–8. doi:10.1007/s12015-007-0006-6. PMID 17873379. S2CID 20861838.
Filleur S, Hirsch J, Wille A, Schön M, Sell C, Shearer MH, Nelius T, Wieland I (2009). "INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling". Cancer Cell International. 9: 28. doi:10.1186/1475-2867-9-28. PMC 2779787 . PMID 19906297.
Balaz P, Plaschke J, Krüger S, Görgens H, Schackert HK (Aug 2010). "TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers". International Journal of Colorectal Disease. 25 (8): 931–9. doi:10.1007/s00384-010-0959-9. PMID 20532534. S2CID 22778766.
Salins P, Shawesh S, He Y, Dibrov A, Kashour T, Arthur G, Amara F (Feb 2007). "Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling". Neuroscience Letters. 412 (3): 211–6. doi:10.1016/j.neulet.2006.07.045. PMID 17234346. S2CID 53251386.
Halatsch ME, Löw S, Mursch K, Hielscher T, Schmidt U, Unterberg A, Vougioukas VI, Feuerhake F (Aug 2009). "Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory investigation". Journal of Neurosurgery. 111 (2): 211–8. doi:10.3171/2008.9.JNS08551. PMID 19301967.
Barker N, Huls G, Korinek V, Clevers H (Jan 1999). "Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium". The American Journal of Pathology. 154 (1): 29–35. doi:10.1016/S0002-9440(10)65247-9. PMC 1853446 . PMID 9916915.
Velasco J, Zarrabeitia MT, Prieto JR, Perez-Castrillon JL, Perez-Aguilar MD, Perez-Nuñez MI, Sañudo C, Hernandez-Elena J, Calvo I, Ortiz F, Gonzalez-Macias J, Riancho JA (Jan 2010). "Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study". Osteoporosis International. 21 (1): 109–18. doi:10.1007/s00198-009-0931-0. PMID 19373426. S2CID 8813712.
Graham TA, Weaver C, Mao F, Kimelman D, Xu W (Dec 2000). "Crystal structure of a beta-catenin/Tcf complex". Cell. 103 (6): 885–96. doi: 10.1016/S0092-8674(00)00192-6 . PMID 11136974. S2CID 16865193.
Lukas J, Mazna P, Valenta T, Doubravska L, Pospichalova V, Vojtechova M, Fafilek B, Ivanek R, Plachy J, Novak J, Korinek V (May 2009). "Dazap2 modulates transcription driven by the Wnt effector TCF-4". Nucleic Acids Research. 37 (9): 3007–20. doi:10.1093/nar/gkp179. PMC 2685103 . PMID 19304756.
Ollila HM, Soronen P, Silander K, Palo OM, Kieseppä T, Kaunisto MA, Lönnqvist J, Peltonen L, Partonen T, Paunio T (Apr 2009). "Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort". Molecular Psychiatry. 14 (4): 351–3. doi:10.1038/mp.2008.122. PMC 2694406 . PMID 19308021.
Pollheimer J, Loregger T, Sonderegger S, Saleh L, Bauer S, Bilban M, Czerwenka K, Husslein P, Knöfler M (Apr 2006). "Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast". The American Journal of Pathology. 168 (4): 1134–47. doi:10.2353/ajpath.2006.050686. PMC 1606554 . PMID 16565489.
Brantjes H, Roose J, van De Wetering M, Clevers H (Apr 2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors". Nucleic Acids Research. 29 (7): 1410–9. doi:10.1093/nar/29.7.1410. PMC 31284 . PMID 11266540.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000152284 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055799 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "TCF7L1 transcription factor 7 like 1 [ Homo sapiens (human) ]" . Retrieved 2021-05-29.

[''Salmonella''_infection-6] "Salmonella infection data for Tcf7l1". Wellcome Trust Sanger Institute.

[''Citrobacter''_infection-7] "Citrobacter infection data for Tcf7l1". Wellcome Trust Sanger Institute.

[mgp_reference-8] 1 2 3 4 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.

[9] Mouse Resources Portal, Wellcome Trust Sanger Institute.

[allele_ref-10] "International Knockout Mouse Consortium".

[mgi_allele_ref-11] "Mouse Genome Informatics".

[pmid21677750-12] Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410 . PMID 21677750.

[mouse_library-13] Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi: 10.1038/474262a . PMID 21677718.

[mouse_for_all_reasons-14] Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi: 10.1016/j.cell.2006.12.018 . PMID 17218247. S2CID 18872015.

[pmid21722353-15] van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837 . PMID 21722353.

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TCF7L1

Contents

Model organisms

Related Research Articles

References

Further reading