TCL1B

TCL1B
Identifiers
Aliases	TCL1B , SYN-1, TML1, T-cell leukemia/lymphoma 1B, T cell leukemia/lymphoma 1B, TCL1 family AKT coactivator B
External IDs	OMIM: 603769 HomoloGene: 81735 GeneCards: TCL1B
Gene location (Human)
Chr.	Chromosome 14 (human)
End	95,692,628 bp
RNA expression pattern
	Top expressed in
	lymph node; ; testicle; ; placenta; ; thymus; ; spleen; ; blood; ; bone marrow; ; appendix; ; mucosa of large intestine; ; gallbladder;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase binding ; protein serine/threonine kinase activator activity ;
Cellular component	protein-containing complex ;
Biological process	positive regulation of peptidyl-serine phosphorylation ; positive regulation of protein serine/threonine kinase activity ; positive regulation of cell population proliferation ;
	Sources:Amigo / QuickGO
Orthologs
	9623
	n/a
	ENSG00000213231
	n/a
	O95988
	n/a
	NM_199206 ; NM_004918
	n/a
	NP_004909
	n/a
	Wikidata
View/Edit Human

Last updated October 17, 2022

T-cell leukemia/lymphoma protein 1B is a protein that in humans is encoded by the TCL1B gene.^[3]^[4]

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In molecular biology, TCL-1/MTCP-1 is a protein domain found in proteins encoded for by two related protooncogenes, other words by genes that help promote cancer. They are, T-cell leukemia/lymphoma protein 1A TCL1A encoded by oncogene TCL-1 SWISSPROT and Protein p13 MTCP-1 encoded by MTCP-1 SWISSPROT.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000213231 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM (May 1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes". Proc Natl Acad Sci U S A. 96 (6): 2949–51. Bibcode:1999PNAS...96.2949P. doi: 10.1073/pnas.96.6.2949 . PMC 15875 . PMID 10077617.
↑ "Entrez Gene: TCL1B T-cell leukemia/lymphoma 1B".

Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia". Oncogene. 20 (40): 5638–43. doi: 10.1038/sj.onc.1204596 . PMID 11607815.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi: 10.1074/jbc.M107069200 . PMID 11707444.
Laine J, Künstle G, Obata T, et al. (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi: 10.1016/S1097-2765(00)00039-3 . PMID 10983986.
Saitou M, Sugimoto J, Hatakeyama T, et al. (2000). "Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia". Oncogene. 19 (23): 2796–802. doi: 10.1038/sj.onc.1203604 . PMID 10851082.
Sugimoto J, Hatakeyama T, Narducci MG, et al. (1999). "Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus". Cancer Res. 59 (10): 2313–7. PMID 10344735.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000213231 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10077617-3] Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM (May 1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes". Proc Natl Acad Sci U S A. 96 (6): 2949–51. Bibcode:1999PNAS...96.2949P. doi: 10.1073/pnas.96.6.2949 . PMC 15875 . PMID 10077617.

[entrez-4] "Entrez Gene: TCL1B T-cell leukemia/lymphoma 1B".

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TCL1B

Related Research Articles

References

Further reading