TGM4

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TGM4
Identifiers
Aliases	TGM4 , TGP, hTGP, TGASE–4, transglutaminase 4
External IDs	OMIM: 600585; MGI: 3027002; HomoloGene: 20689; GeneCards: TGM4; OMA:TGM4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p21.31 Start 44,874,608 bp [1] End 44,914,990 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 F4 Start 122,863,791 bp [2] End 122,896,626 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle prostate bone marrow monocyte appendix granulocyte gonad right testis left testis right coronary artery Top expressed in neural layer of retina spinal ganglia granulocyte prostate primary oocyte embryo morula secondary oocyte muscle of thigh embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acyltransferase activity protein-glutamine gamma-glutamyltransferase activity metal ion binding Cellular component cytoplasm extracellular matrix Golgi apparatus extracellular exosome collagen-containing extracellular matrix Biological process peptide cross-linking Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7047 331046 Ensembl ENSG00000163810 ENSG00000281886 ENSMUSG00000025787 UniProt P49221 Q8BZH1 RefSeq (mRNA) NM_003241 NM_177911 RefSeq (protein) NP_003232 NP_808579 Location (UCSC) Chr 3: 44.87 – 44.91 Mb Chr 9: 122.86 – 122.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein-glutamine gamma-glutamyltransferase 4 is an enzyme that in humans is encoded by the TGM4 gene. ^{[5] [6] [7]}

References

1. ENSG00000281886 GRCh38: Ensembl release 89: ENSG00000163810, ENSG00000281886 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025787 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gentile V, Grant FJ, Porta R, Baldini A (Oct 1995). "Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization". Genomics. 27 (1): 219–20. doi:10.1006/geno.1995.1032. PMID   7665178.
6. Grant FJ, Taylor DA, Sheppard PO, Mathewes SL, Lint W, Vanaja E, Bishop PD, O'Hara PJ (Oct 1994). "Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library". Biochem Biophys Res Commun. 203 (2): 1117–23. doi:10.1006/bbrc.1994.2298. PMID   7916568.
7. "Entrez Gene: TGM4 transglutaminase 4 (prostate)".

Further reading

• Davies G, Ablin RJ, Mason MD, Jiang WG (2007). "Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer". J. Exp. Ther. Oncol. 6 (3): 257–64. PMID   17552366.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Dubbink HJ, de Waal L, van Haperen R, et al. (1998). "The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization". Genomics. 51 (3): 434–44. doi:10.1006/geno.1998.5393. PMID   9721214.
• Dubbink HJ, Verkaik NS, Faber PW, et al. (1996). "Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase". Biochem. J. 315 ( Pt 3) (Pt 3): 901–8. doi:10.1042/bj3150901. PMC   1217292 . PMID   8645175.
• Amendola A, Lombardi G, Oliverio S, et al. (1994). "HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A". FEBS Lett. 339 (3): 258–64. doi: 10.1016/0014-5793(94)80427-3 . PMID   7906657. S2CID   39872629.
• Mariniello L, Esposito C, Di Pierro P, et al. (1993). "Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro". Eur. J. Biochem. 215 (1): 99–104. doi: 10.1111/j.1432-1033.1993.tb18011.x . PMID   7688299.