TGM4

TGM4
Identifiers
Aliases	TGM4 , TGP, hTGP, TGASE–4, transglutaminase 4
External IDs	OMIM: 600585 MGI: 3027002 HomoloGene: 20689 GeneCards: TGM4
Gene location (Human)
Chr.	Chromosome 3 (human)
End	44,914,990 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	122,896,626 bp
RNA expression pattern
	Top expressed in
	prostate; ; bone marrow; ; monocyte; ; appendix; ; right coronary artery; ; right adrenal gland; ; canal of the cervix; ; gastrocnemius muscle; ; skeletal muscle tissue; ; thymus;
	Top expressed in
	spinal ganglia; ; prostate; ; morula; ; secondary oocyte; ; blastocyst; ; blood; ; esophagus; ; cumulus cell; ; proximal tubule; ; muscle tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; acyltransferase activity ; protein-glutamine gamma-glutamyltransferase activity ; metal ion binding ;
Cellular component	cytoplasm ; extracellular matrix ; Golgi apparatus ; extracellular exosome ; collagen-containing extracellular matrix ;
Biological process	peptide cross-linking ;
	Sources:Amigo / QuickGO
Orthologs
	7047
	331046
	ENSG00000163810 ; ENSG00000281886
	ENSMUSG00000025787
	P49221
	Q8BZH1
	NM_003241
	NM_177911
	NP_003232
	NP_808579
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 08, 2023

Protein-glutamine gamma-glutamyltransferase 4 is an enzyme that in humans is encoded by the TGM4 gene.^[5]^[6]^[7]

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References

1 2 3 ENSG00000281886 GRCh38: Ensembl release 89: ENSG00000163810, ENSG00000281886 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025787 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gentile V, Grant FJ, Porta R, Baldini A (Oct 1995). "Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization". Genomics. 27 (1): 219–20. doi:10.1006/geno.1995.1032. PMID 7665178.
↑ Grant FJ, Taylor DA, Sheppard PO, Mathewes SL, Lint W, Vanaja E, Bishop PD, O'Hara PJ (Oct 1994). "Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library". Biochem Biophys Res Commun. 203 (2): 1117–23. doi:10.1006/bbrc.1994.2298. PMID 7916568.
↑ "Entrez Gene: TGM4 transglutaminase 4 (prostate)".

Davies G, Ablin RJ, Mason MD, Jiang WG (2007). "Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer". J. Exp. Ther. Oncol. 6 (3): 257–64. PMID 17552366.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Dubbink HJ, de Waal L, van Haperen R, et al. (1998). "The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization". Genomics. 51 (3): 434–44. doi:10.1006/geno.1998.5393. PMID 9721214.
Dubbink HJ, Verkaik NS, Faber PW, et al. (1996). "Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase". Biochem. J. 315 ( Pt 3) (Pt 3): 901–8. doi:10.1042/bj3150901. PMC 1217292 . PMID 8645175.
Amendola A, Lombardi G, Oliverio S, et al. (1994). "HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A". FEBS Lett. 339 (3): 258–64. doi: 10.1016/0014-5793(94)80427-3 . PMID 7906657. S2CID 39872629.
Mariniello L, Esposito C, Di Pierro P, et al. (1993). "Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro". Eur. J. Biochem. 215 (1): 99–104. doi: 10.1111/j.1432-1033.1993.tb18011.x . PMID 7688299.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000281886 GRCh38: Ensembl release 89: ENSG00000163810, ENSG00000281886 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025787 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7665178-5] Gentile V, Grant FJ, Porta R, Baldini A (Oct 1995). "Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization". Genomics. 27 (1): 219–20. doi:10.1006/geno.1995.1032. PMID 7665178.

[pmid7916568-6] Grant FJ, Taylor DA, Sheppard PO, Mathewes SL, Lint W, Vanaja E, Bishop PD, O'Hara PJ (Oct 1994). "Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library". Biochem Biophys Res Commun. 203 (2): 1117–23. doi:10.1006/bbrc.1994.2298. PMID 7916568.

[entrez-7] "Entrez Gene: TGM4 transglutaminase 4 (prostate)".

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TGM4

Related Research Articles

References

Further reading