TGOLN2

TGOLN2
Identifiers
Aliases	TGOLN2 , TGN38, TGN46, TGN48, TGN51, TTGN2, trans-golgi network protein 2, hTGN46, hTGN48, hTGN51
External IDs	OMIM: 603062 HomoloGene: 136490 GeneCards: TGOLN2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,328,251 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; parotid gland; ; caput epididymis; ; lactiferous duct; ; lower lobe of lung; ; corpus epididymis; ; visceral pleura; ; jejunal mucosa; ; subthalamic nucleus; ; pylorus;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	integral component of membrane ; trans-Golgi network ; Golgi apparatus ; trans-Golgi network transport vesicle ; transport vesicle ; membrane ; nucleoplasm ; cytosol ; plasma membrane ; clathrin-coated vesicle membrane ; endoplasmic reticulum lumen ; endosome ;
Biological process	Golgi to endosome transport ; membrane organization ; post-translational protein modification ;
	Sources:Amigo / QuickGO
Orthologs
	10618
	n/a
	ENSG00000152291
	n/a
	O43493
	n/a
NM_006464 ; NM_001206840 ; NM_001206841 ; NM_001206844 ; NM_001368095 ;
	NM_001368096
	n/a
NP_001193769 ; NP_001193770 ; NP_001193773 ; NP_006455 ; NP_001355024 ;
	NP_001355025
	n/a
	Wikidata
View/Edit Human

Last updated March 04, 2023

Trans-Golgi network integral membrane protein 2 is a protein that in humans is encoded by the TGOLN2 gene.^[3]^[4]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000152291 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kain R, Angata K, Kerjaschki D, Fukuda M (Feb 1998). "Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs". J Biol Chem. 273 (2): 981–8. doi: 10.1074/jbc.273.2.981 . PMID 9422759.
↑ "Entrez Gene: TGOLN2 trans-golgi network protein 2".

Ohno H, Stewart J, Fournier MC, et al. (1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science. 269 (5232): 1872–5. Bibcode:1995Sci...269.1872O. doi:10.1126/science.7569928. PMID 7569928.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Ponnambalam S, Girotti M, Yaspo ML, et al. (1997). "Primate homologues of rat TGN38: primary structure, expression and functional implications". J. Cell Sci. 109 (3): 675–85. doi:10.1242/jcs.109.3.675. PMID 8907712.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Stephens DJ, Banting G (1998). "Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120". Biochem. J. 335 (Pt 3): 567–72. doi:10.1042/bj3350567. PMC 1219817 . PMID 9794796.
Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi: 10.1074/jbc.274.42.30080 . PMID 10514494.
Wang J, Howell KE (2001). "The luminal domain of TGN38 interacts with integrin beta 1 and is involved in its trafficking". Traffic. 1 (9): 713–23. doi:10.1034/j.1600-0854.2000.010904.x. PMID 11208159. S2CID 22784729.
Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Yeaman C, Ayala MI, Wright JR, et al. (2004). "Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network". Nat. Cell Biol. 6 (2): 106–12. doi:10.1038/ncb1090. PMC 3372901 . PMID 14743217.
Höning S, Ricotta D, Krauss M, et al. (2005). "Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2" (PDF). Mol. Cell. 18 (5): 519–31. doi:10.1016/j.molcel.2005.04.019. hdl: 11379/18706 . PMID 15916959.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000152291 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9422759-3] Kain R, Angata K, Kerjaschki D, Fukuda M (Feb 1998). "Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs". J Biol Chem. 273 (2): 981–8. doi: 10.1074/jbc.273.2.981 . PMID 9422759.

[entrez-4] "Entrez Gene: TGOLN2 trans-golgi network protein 2".

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[3]

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TGOLN2

Related Research Articles

References

Further reading