THG1L

THG1L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OTB, 3OTC, 3OTD, 3OTE
Identifiers
Aliases	THG1L , ICF45, IHG-1, hTHG1, tRNA-histidine guanylyltransferase 1 like, SCAR28, IHG1, THG1
External IDs	MGI: 1913878; HomoloGene: 5959; GeneCards: THG1L; OMA:THG1L - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q33.3 Start 157,731,420 bp [1] End 157,741,449 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.1 Start 45,837,670 bp [2] End 45,846,321 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte cartilage tissue stromal cell of endometrium secondary oocyte mucosa of transverse colon rectum sperm ventricular zone testicle gonad Top expressed in spermatocyte embryo spermatid epiblast yolk sac zygote embryo genital tubercle tail of embryo secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding tRNA binding GTP binding protein binding ATP binding magnesium ion binding metal ion binding tRNA guanylyltransferase activity identical protein binding nucleotidyltransferase activity Cellular component cytoplasm cytosol mitochondrion Biological process tRNA modification protein homotetramerization tRNA processing tRNA 5'-end processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54974 66628 Ensembl ENSG00000113272 ENSMUSG00000011254 UniProt Q9NWX6 Q9CY52 RefSeq (mRNA) NM_017872 NM_001317824 NM_001317825 NM_001317826 NM_001080969 NM_001290737 RefSeq (protein) NP_001304753 NP_001304754 NP_001304755 NP_060342 NP_001074438 NP_001277666 Location (UCSC) Chr 5: 157.73 – 157.74 Mb Chr 11: 45.84 – 45.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable tRNA(His) guanylyltransferase is an enzyme that in humans is encoded by the THG1L gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000113272 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000011254 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
6. "Entrez Gene: THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Guo D, Hu K, Lei Y, et al. (2005). "Identification and characterization of a novel cytoplasm protein ICF45 that is involved in cell cycle regulation". J. Biol. Chem. 279 (51): 53498–505. doi: 10.1074/jbc.M406737200 . PMID   15459185.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.