TIMM10B

TIMM10B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BSK
Identifiers
Aliases	TIMM10B , FXC1, TIM10B, Tim9b, translocase of inner mitochondrial membrane 10 homolog B (yeast), translocase of inner mitochondrial membrane 10B
External IDs	OMIM: 607388; MGI: 1315196; HomoloGene: 8142; GeneCards: TIMM10B; OMA:TIMM10B - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 6,481,501 bp [1] End 6,484,681 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 105,640,056 bp [2] End 105,643,637 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tibia sperm gonad saphenous vein epithelium of colon superior vestibular nucleus spinal ganglia ventral tegmental area amniotic fluid Top expressed in granulocyte right kidney embryo embryo muscle of thigh lip ventricular zone superior frontal gyrus yolk sac cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding Cellular component mitochondrial inner membrane mitochondrial intermembrane space mitochondrial intermembrane space protein transporter complex mitochondrion membrane TIM22 mitochondrial import inner membrane insertion complex Biological process protein transport protein targeting to mitochondrion cell-matrix adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26515 14356 Ensembl ENSG00000132286 ENSMUSG00000089847 UniProt Q9Y5J6 Q9WV96 RefSeq (mRNA) NM_012192 NM_019502 RefSeq (protein) NP_036324 NP_062375 NP_001346981 NP_001346982 NP_001346983 NP_001346984 NP_001346985 NP_001346987 NP_001346988 NP_001346989 NP_001346990 Location (UCSC) Chr 11: 6.48 – 6.48 Mb Chr 7: 105.64 – 105.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial import inner membrane translocase subunit Tim9 B is an enzyme that in humans is encoded by the FXC1 gene. ^{[5] [6]}

FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000132286 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000089847 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Feb 2000). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID   10552927.
6. "Entrez Gene: FXC1 fracture callus 1 homolog (rat)".

Further reading

• Hadjiargyrou M, Halsey MF, Ahrens W, et al. (1998). "Cloning of a novel cDNA expressed during the early stages of fracture healing". Biochem. Biophys. Res. Commun. 249 (3): 879–84. doi:10.1006/bbrc.1998.9167. PMID   9731230.
• Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Lett. 464 (1–2): 41–7. doi: 10.1016/S0014-5793(99)01665-8 . PMID   10611480. S2CID   27484018.
• Rothbauer U, Hofmann S, Mühlenbein N, et al. (2001). "Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria". J. Biol. Chem. 276 (40): 37327–34. doi: 10.1074/jbc.M105313200 . PMID   11489896.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J. Biol. Chem. 279 (14): 13540–6. doi: 10.1074/jbc.M312485200 . PMID   14726512.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.