182 kDa tankyrase-1-binding protein is an enzyme that in humans is encoded by the TNKS1BP1 gene. [5] [6]
182 kDa tankyrase-1-binding protein is an enzyme that in humans is encoded by the TNKS1BP1 gene. [5] [6]
Telomeric repeat-binding factor 1 is a protein that in humans is encoded by the TERF1 gene.
Tankyrase, also known as tankyrase 1, is an enzyme that in humans is encoded by the TNKS gene. It inhibits the binding of TERF1 to telomeric DNA. Tankyrase attracts substantial interest in cancer research through its interaction with AXIN1 and AXIN2, which are negative regulators of pro-oncogenic β-catenin signaling. Importantly, activity in the β-catenin destruction complex can be increased by tankyrase inhibitors and thus such inhibitors are a potential therapeutic option to reduce the growth of β-catenin-dependent cancers.
Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.
Serine/arginine repetitive matrix protein 2 is a protein that in humans is encoded by the SRRM2 gene.
Pumilio homolog 2 is an RNA-binding protein that in humans is encoded by the PUM2 gene.
Probable E3 ubiquitin-protein ligase MYCBP2 also known as myc-binding protein 2 or protein associates with myc (PAM) is an enzyme that in humans is encoded by the MYCBP2 gene.
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1), or DCC-interacting protein 13-alpha (DIP13alpha), is a protein that in humans is encoded by the APPL1 gene. APPL1 contains several key interactory domains: pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain and Bin–Amphiphysin–Rvs (BAR) domain.
Glutamate receptor-interacting protein 2 is a protein that in humans is encoded by the GRIP2 gene.
Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.
Sentrin-specific protease 2 is an enzyme that in humans is encoded by the SENP2 gene.
Protein transport protein Sec16A is a protein that in humans is encoded by the SEC16A gene.
Signal-induced proliferation-associated 1-like protein 1 is a protein that in humans is encoded by the SIPA1L1 gene.
CTTNBP2 N-terminal-like protein is a protein that in humans is encoded by the CTTNBP2NL gene. It is a substrate for phosphorylation.
Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.
Transcriptional repressor p66-beta is a protein that in humans is encoded by the GATAD2B gene.
Scaffold attachment factor B2 is a protein that in humans is encoded by the SAFB2 gene.
Brain-enriched guanylate kinase-associated protein is an enzyme that in humans is encoded by the BEGAIN gene.
Interferon regulatory factor 2 binding protein like is a protein that in humans is encoded by the IRF2BPL gene. Mutations are associated with neurological problems. More specifically, mutations of the gene cause the NEDAMSS syndrome, whose abbreviation stands for NEurodevelopmental Disorder with regression, Abnormal Movements, loss of Speech, and Seizures, first described in 2018.
Chromosome alignment-maintaining phosphoprotein 1 (CHAMP1) also known as zinc finger protein 828 (ZNF828) is a protein that in humans is encoded by the CHAMP1 gene.
Ribonucleoprotein, PTB-binding 1, is a human gene.
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