TP53I3

TP53I3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2J8Z, 2OBY
Identifiers
Aliases	TP53I3 , PIG3, tumor protein p53 inducible protein 3
External IDs	OMIM: 605171 HomoloGene: 36617 GeneCards: TP53I3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	24,085,861 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; duodenum; ; rectum; ; body of pancreas; ; vagina; ; gallbladder; ; upper lobe of left lung; ; tibial nerve; ; jejunal mucosa; ; kidney;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity ; protein homodimerization activity ; NADPH binding ; quinone binding ; NADPH:quinone reductase activity ;
Cellular component	cytosol ;
Biological process	NADP metabolic process ; regulation of apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	9540
	n/a
	ENSG00000115129
	n/a
	Q53FA7
	n/a
	NM_001206802 ; NM_004881 ; NM_147184
	n/a
	NP_001193731 ; NP_004872 ; NP_671713
	n/a
	Wikidata
View/Edit Human

Last updated March 04, 2023

Putative quinone oxidoreductase is an enzyme that in humans is encoded by the TP53I3 gene.^[3]^[4]^[5]^[6]

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene.^[6]

Related Research Articles

A microsatellite is a tract of repetitive DNA in which certain DNA motifs are repeated, typically 5–50 times. Microsatellites occur at thousands of locations within an organism's genome. They have a higher mutation rate than other areas of DNA leading to high genetic diversity. Microsatellites are often referred to as short tandem repeats (STRs) by forensic geneticists and in genetic genealogy, or as simple sequence repeats (SSRs) by plant geneticists.

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.

Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene. ELGN2 is an alpha-ketoglutarate-dependent hydroxylase, a superfamily of non-haem iron-containing proteins.

40S ribosomal protein S3a is a protein that in humans is encoded by the RPS3A gene.

NAD(P)H dehydrogenase, quinone 2, also known as QR2, is a protein that in humans is encoded by the NQO2 gene. It is a phase II detoxification enzyme which can carry out two or four electron reductions of quinones. Its mechanism of reduction is through a ping-pong mechanism involving its FAD cofactor. Initially in a reductive phase NQO2 binds to reduced dihydronicotinamide riboside (NRH) electron donor, and mediates a hydride transfer from NRH to FAD. Then, in an oxidative phase, NQO2 binds to its quinone substrate and reduces the quinone to a dihydroquinone. Besides the two catalytic FAD, NQO2 also has two zinc ions. It is not clear whether the metal has a catalytic role. NQO2 is a paralog of NQO1

NQO2 is a homodimer. NQO2 can be inhibited by resveratrol. One of QR2's binding sites responds to 2-iodomelatonin, and has been referred to as MT₃.

Lipopolysaccharide-induced tumor necrosis factor-alpha factor is a protein that in humans is encoded by the LITAF gene.

Large proline-rich protein BAT2 is a protein that in humans is encoded by the BAT2 gene.

Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene.

Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene.

DnaJ homolog subfamily B member 9 is a protein that in humans is encoded by the DNAJB9 gene.

G2 and S phase-expressed protein 1 is an enzyme that in humans is encoded by the GTSE1 gene.

60S ribosomal protein L23 is a protein that in humans is encoded by the RPL23 gene.

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a protein which in humans is encoded by the LRDD gene.

Galectin-7 is a protein that in humans is encoded by the LGALS7 gene.

NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial is an enzyme that in humans is encoded by the NDUFV3 gene.

39S ribosomal protein L41, mitochondrial is a protein that in humans is encoded by the MRPL41 gene.

Tumor protein p53-inducible protein 11 is a protein that in humans is encoded by the TP53I11 gene.

Dual serine/threonine and tyrosine protein kinase is an enzyme that in humans is encoded by the DSTYK gene.

Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115129 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Contente A, Dittmer A, Koch MC, Roth J, Dobbelstein M (Mar 2002). "A polymorphic microsatellite that mediates induction of PIG3 by p53". Nat Genet. 30 (3): 315–20. doi:10.1038/ng836. PMID 11919562. S2CID 19112465.
↑ Flatt PM, Polyak K, Tang LJ, Scatena CD, Westfall MD, Rubinstein LA, Yu J, Kinzler KW, Vogelstein B, Hill DE, Pietenpol JA (Jul 2000). "p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest". Cancer Lett. 156 (1): 63–72. doi:10.1016/S0304-3835(00)00441-9. PMID 10840161.
↑ Porte S, Valencia E, Yakovtseva EA, Borras E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farres J, Fita I, Pares X (Jun 2009). "Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3". J Biol Chem. 284 (25): 17194–205. doi: 10.1074/jbc.M109.001800 . PMC 2719357 . PMID 19349281.
1 2 "Entrez Gene: TP53I3 tumor protein p53 inducible protein 3".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Polyak K, Xia Y, Zweier JL, et al. (1997). "A model for p53-induced apoptosis". Nature. 389 (6648): 300–5. Bibcode:1997Natur.389..300P. doi:10.1038/38525. PMID 9305847. S2CID 4429638.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Nicholls CD, Shields MA, Lee PW, et al. (2004). "UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation". J. Biol. Chem. 279 (23): 24171–8. doi: 10.1074/jbc.M401049200 . PMID 15067011.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID 15815621.
Rohaly G, Chemnitz J, Dehde S, et al. (2005). "A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint". Cell. 122 (1): 21–32. doi: 10.1016/j.cell.2005.04.032 . PMID 16009130. S2CID 2350226.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115129 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11919562-3] Contente A, Dittmer A, Koch MC, Roth J, Dobbelstein M (Mar 2002). "A polymorphic microsatellite that mediates induction of PIG3 by p53". Nat Genet. 30 (3): 315–20. doi:10.1038/ng836. PMID 11919562. S2CID 19112465.

[pmid10840161-4] Flatt PM, Polyak K, Tang LJ, Scatena CD, Westfall MD, Rubinstein LA, Yu J, Kinzler KW, Vogelstein B, Hill DE, Pietenpol JA (Jul 2000). "p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest". Cancer Lett. 156 (1): 63–72. doi:10.1016/S0304-3835(00)00441-9. PMID 10840161.

[pmid19349281-5] Porte S, Valencia E, Yakovtseva EA, Borras E, Shafqat N, Debreczeny JE, Pike AC, Oppermann U, Farres J, Fita I, Pares X (Jun 2009). "Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3". J Biol Chem. 284 (25): 17194–205. doi: 10.1074/jbc.M109.001800 . PMC 2719357 . PMID 19349281.

[entrez-6] 1 2 "Entrez Gene: TP53I3 tumor protein p53 inducible protein 3".

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TP53I3

Related Research Articles

References

Further reading