TXNRD1

Last updated
TXNRD1
Protein TXNRD1 PDB 1h6v.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TXNRD1 , GRIM-12, TR, TR1, TRXR1, TXNR, thioredoxin reductase 1
External IDs OMIM: 601112; MGI: 1354175; HomoloGene: 55733; GeneCards: TXNRD1; OMA:TXNRD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042513
NM_001042514
NM_001042523
NM_015762

RefSeq (protein)

NP_001035978
NP_001035979
NP_001035988
NP_056577

Location (UCSC) Chr 12: 104.22 – 104.35 Mb Chr 10: 82.67 – 82.73 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene. [5]

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198431 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020250 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gasdaska PY, Gasdaska JR, Cochran S, Powis G (Nov 1995). "Cloning and sequencing of a human thioredoxin reductase". FEBS Lett. 373 (1): 5–9. doi: 10.1016/0014-5793(95)01003-W . PMID   7589432. S2CID   735874.
  6. "Entrez Gene: TXNRD1 thioredoxin reductase 1".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.