TXNRD1

Last updated
TXNRD1
Protein TXNRD1 PDB 1h6v.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TXNRD1 , GRIM-12, TR, TR1, TRXR1, TXNR, thioredoxin reductase 1
External IDs OMIM: 601112 MGI: 1354175 HomoloGene: 55733 GeneCards: TXNRD1
Gene location (Human)
Ideogram human chromosome 12.svg
Chr. Chromosome 12 (human) [1]
Human chromosome 12 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 12q23.3Start104,215,779 bp [1]
End104,350,307 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042513
NM_001042514
NM_001042523
NM_015762

RefSeq (protein)

NP_001035978
NP_001035979
NP_001035988
NP_056577

Location (UCSC) Chr 12: 104.22 – 104.35 Mb Chr 10: 82.83 – 82.9 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene. [5]

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [6]

See also

Related Research Articles

Selenocysteine

Selenocysteine is the 21st proteinogenic amino acid.

Thyroxine 5-deiodinase Protein-coding gene in the species Homo sapiens

Thyroxine 5-deiodinase also known as type III iodothyronine deiodinase (EC number 1.21.99.3) is an enzyme that in humans is encoded by the DIO3 gene. This enzyme catalyses the following chemical reaction

SEPP1

Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.

SELS (gene)

Selenoprotein S, also known as SELS, is a human gene.

Selenophosphate synthetase 1

Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.

SEPN1

Selenoprotein N is a protein that in humans is encoded by the SEPN1 gene.

SECISBP2

SECIS-binding protein 2 is a protein that in humans is encoded by the SECISBP2 gene.

SEP15

15 kDa selenoprotein is a protein that in humans is encoded by the SEP15 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

SEPW1

Selenoprotein W is a protein that in humans is encoded by the SEPW1 gene.

SEPX1

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.

DIO2

Type II iodothyronine deiodinase is an enzyme that in humans is encoded by the DIO2 gene.

SELT

Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene.

GPX3

Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3 gene.

GPX5

Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene.

GPX6

Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene.

SRD5A3

Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene. It is one of three forms of 5α-reductase.

Inositol monophosphatase 3

Inositol monophosphatase 3 also known as inositol monophosphatase domain-containing protein 1 (IMPAD1) is an enzyme that in humans is encoded by the IMPAD1 gene.

Biliverdin reductase A

Biliverdin reductase A is a protein that in humans is encoded by the BLVRA gene.

Selenoprotein o

Selenoprotein O is a protein that in humans is encoded by the SELENOO gene.

AKR1C2

Aldo-keto reductase family 1 member C2, also known as bile acid binding protein, 3α-hydroxysteroid dehydrogenase type 3, and dihydrodiol dehydrogenase type 2, is an enzyme that in humans is encoded by the AKR1C2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198431 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020250 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gasdaska PY, Gasdaska JR, Cochran S, Powis G (Nov 1995). "Cloning and sequencing of a human thioredoxin reductase". FEBS Lett. 373 (1): 5–9. doi: 10.1016/0014-5793(95)01003-W . PMID   7589432. S2CID   735874.
  6. "Entrez Gene: TXNRD1 thioredoxin reductase 1".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.