U.S. Route 19 or U.S. Highway 19 (US 19) is a north–south United States Numbered Highway in the Eastern United States. Despite encroaching Interstate Highways, the route has remained a long-haul road, connecting the Gulf of Mexico with Lake Erie.
U.S. Route 21 or U.S. Highway 21 (US 21) is a major north–south United States Numbered Highway in the Southeastern United States that travels 394 miles (634 km). The southern terminus is in Hunting Island State Park, South Carolina, 14.4 miles (23.2 km) south of the junction with US 21 Business and South Carolina Highway 802 (SC 802) in Beaufort. The northern terminus is in Wytheville, Virginia at an interchange with Interstate 81 (I-81) and US 52. Despite the "1" indicating that it is a major north-south highway, U.S. 21 only travels through three states, and is no longer a cross-country route as it has been replaced with Interstate 77 in both Ohio and West Virginia. It also has the second-shortest length of all of the major north-south routes, just behind U.S. 91. The route travels through the states of South Carolina, North Carolina, and Virginia. It also connects through major Southeastern cities such as Columbia, South Carolina and Charlotte, North Carolina. The northern portion of the road travels parallel to I-77 in northern South Carolina and North Carolina. The road also has three interchanges with I-26 in Lexington and Calhoun counties in South Carolina.
U.S. Route 501 is a spur of U.S. Route 1. It runs 355 miles (571 km) from Buena Vista, Virginia at U.S. Route 60 to Myrtle Beach, South Carolina at U.S. Route 17 Business. It passes through the states of Virginia, North Carolina and South Carolina. From Durham to Laurinburg, a 108-mile (174 km) section of US 501 overlaps U.S. Route 15. Sections of US 15-501 also share routings with U.S. Route 1 in sections near Sanford, North Carolina and Aberdeen, North Carolina.
U.S. Route 321 (US 321) is a spur of U.S. Route 21. It runs for 516.9 miles (831.9 km) from Hardeeville, South Carolina to Lenoir City, Tennessee; with both serving as southern termini. It reaches its northernmost point at Elizabethton, Tennessee, just northeast of Johnson City. Because of its unusual "north–south–north" routing, U.S. Route 321 intersects both Interstate 40 and U.S. Route 70 three separate times. The highway serves different roles in each state: An alternate route to interstates in South Carolina, a major highway in North Carolina, and a scenic route in Tennessee.
U.S. Route 129 (US 129) is an auxiliary route of US 29, which it intersects in Athens, Georgia. US 129 currently runs for 582 miles (937 km) from an intersection with US 19/US 27 ALT/US 98 in Chiefland, Florida, to an interchange with Interstate 40 (I-40) in Knoxville, Tennessee. It passes through the states of Florida, Georgia, North Carolina, and Tennessee. It goes through the cities of Macon, Athens, Gainesville, and Knoxville.
U.S. Route 258 is a spur of US 58 in the U.S. states of North Carolina and Virginia. The U.S. Highway runs 220.15 miles (354.30 km) from US 17 Business and NC 24 Business in Jacksonville, North Carolina north to Virginia State Route 143 at Fort Monroe in Hampton, Virginia. In North Carolina, US 258 connects Jacksonville with the Inner Banks communities of Kinston, Snow Hill, Farmville, Tarboro, and Murfreesboro. The U.S. Highway continues through the Virginia city of Franklin, where the highway intersects US 58, and the town of Smithfield on its way to the Hampton Roads metropolitan area. US 258 crosses the James River on the James River Bridge and follows Mercury Boulevard through Newport News and Hampton.
U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 715 miles (1,151 km) from Memphis, Tennessee, to Charleston, South Carolina. From Byhalia, Mississippi to Birmingham, Alabama, US 78 runs concurrently with Interstate 22 (I-22). The highway's western terminus is at US 64/US 70/US 79 in Memphis, and its eastern terminus is on Line Street, in Charleston.
U.S. Route 19E (US 19E) is a divided highway of US 19 in the U.S. states of North Carolina and Tennessee. The United States Numbered Highway, which is complemented by US 19W to the west, travels 75.9 miles (122.1 km) from US 19 and US 19W at Cane River, North Carolina, north to US 11E, US 19, and US 19W in Bluff City, Tennessee. US 19E connects Asheville, North Carolina, and Bristol, Tennessee, with Burnsville, Spruce Pine, and Elk Park in North Carolina and Roan Mountain and Elizabethton in Tennessee. US 19E also has an unsigned concurrency with State Route 37 (SR 37) for its entire course in Tennessee.
U.S. Route 11E (US 11E) is a divided highway of US 11 in the U.S. states of Tennessee and Virginia. The United States Numbered Highway, which is complemented by US 11W to the north and west, runs 120.94 miles (194.63 km) from US 11, US 11W, and US 70 in Knoxville, Tennessee, north and east to US 11, US 11W, US 19, and US 421 in Bristol, Virginia. US 11E connects Knoxville and the twin cities of Bristol, Virginia, and Bristol, Tennessee, with the East Tennessee communities of Morristown, Greeneville, and Johnson City. The U.S. Highway runs concurrently with US 70 and US 25W east of Knoxville, US 321 from Greeneville and Johnson City, and both US 19W and US 19 between Johnson City and Bristol. US 11E also has an unsigned concurrency with State Route 34 (SR 34) for almost all of its course in Tennessee.
North Carolina Highway 226 (NC 226) is a primary state highway in the U.S. state of North Carolina. Traveling north–south through Western North Carolina, it connects the cities and towns of Grover, Shelby, Marion, Spruce Pine and Bakersville. It also a scenic byway in the South Mountains area and connects with the summer colony of Little Switzerland, via NC 226A.
North Carolina Highway 16 (NC 16) is a 143.8-mile primary state highway in the U.S. state of North Carolina. Traveling in a north–south direction, it connects the cities and towns of Charlotte, Newton, Conover, Taylorsville, Wilkesboro and Jefferson, linking the Charlotte metropolitan area with the mountainous High Country. NC 16 is part of a three-state route 16 that connects the Charlotte region with northwestern West Virginia.
North Carolina Highway 211 (NC 211) is a 162.5-mile-long (261.5 km) primary state highway in the U.S. state of North Carolina. It traverses mostly through the Sandhills and Coastal Plain regions of the state; connecting the cities of Candor, Aberdeen, Raeford, Lumberton, Bladenboro, and Southport.
State Route 66 is a state-maintained highway in eastern Tennessee, including a six-lane divided highway known as Winfield Dunn Parkway in Sevier County, a four-lane expressway in Hamblen and Jefferson counties and a two-lane rural collector through mountainous terrain continuing to the northeast terminus in Hancock County.
State Route 67 is a state-maintained highway in northeastern Tennessee, including a four-lane divided highway segments in both Washington County and Carter County, and part of a significant two-lane segment passing over the Butler Bridge some 80 feet (24 m) above the TVA Watauga Reservoir near Butler in Johnson County, Tennessee.
U.S. Route 129 (US 129) is a 375-mile-long (604 km) U.S. Highway in the U.S. state of Georgia. It travels south-to-north from the Florida state line, south of Statenville, to the North Carolina state line, northwest of Blairsville.
State Route 70 is a state-maintained highway in East Tennessee, beginning at the border with North Carolina in the midst of the Cherokee National Forest and the Great Smoky Mountains and ending at the Virginia border in the extremely rural and mountainous terrain of Hancock County.
North Carolina Highway 194 (NC 194) is a primary state highway in the U.S. state of North Carolina. Entirely in the High Country, it runs from US 19E, in Ingalls, to the Virginia state line, near Helton.
North Carolina Highway 261 (NC 261) is a short state highway going from Bakersville to the Tennessee state line where the road turns into Tennessee State Route 143 (SR 143). The road is only 12.8 miles (20.6 km) long and is very curvy. The road is close to Roan Mountain State Park in Tennessee.
State Route 173 (SR 173) is a state highway in Unicoi and Carter counties in the U.S. state of Tennessee. It connects the town of Unicoi with the community of Tiger Valley.
State Route 167 is a state highway in Johnson County, Tennessee and a spur route of Tennessee State Route 67.
NC 261 at the North Carolina state line near Roan Mountain State Park 
US 19E in Roan Mountain 
