State Route 56 is a 160.6-mile-long (258.5 km) state highway that runs south to north in Middle Tennessee, from the Alabama state line near Sherwood to the Kentucky state line near Red Boiling Springs.
State Route 22 is a 172.8-mile long (278.1 km) south-to-north state highway in the western part of Tennessee, United States. It begins at the Mississippi state line in McNairy County, where the roadway continues as Mississippi Highway 2. It ends at the Kentucky state line in Lake County, when it crosses into the Kentucky Bend, a detached portion of Fulton County, Kentucky. The monument for the 1862 Battle of Island Number Ten in the American Civil War is located on SR 22, about 3 mi (4.8 km) north of Tiptonville.
State Route 14 is a south–north route from the Mississippi border in Memphis, Tennessee to an intersection with State Route 54 in Tipton County.
State Route 5 is a 120-mile-long (190 km) north–south state highway in the western part of the U.S. state of Tennessee. Except for the section northwest of Union City, it is entirely concurrent with U.S. Route 45 and US 45W.
State Route 20 (SR 20) is a 143.04-mile (230.20 km) long east–west primary state highway that begins in Dyersburg and ending near Summertown. SR 20 is unsigned and concurrent with U.S. Route 412 (US 412) for its entire length, except for a short section between Hohenwald and Summertown. Along its route, SR 20 traverses parts of both Middle Tennessee and West Tennessee.
State Route 15 is a west–east route from Memphis to Monteagle. For much of its route it has an unsigned concurrency with U.S. Route 64. SR 15 does travel through the southern part of all three Grand Divisions of the state: West Tennessee, Middle Tennessee, and East Tennessee.
U.S. Route 31A is a 76.94-mile-long (123.82 km) alternate route of U.S. Route 31 that exists between Nashville and Pulaski, Tennessee. It is located entirely in Middle Tennessee and except for the Lewisburg bypass, where it is concurrent with SR 106, it is entirely concurrent with unsigned State Route 11.
State Route 50 (SR 50) is a west–to–east highway in Middle Tennessee. The road begins near Only and ends in Altamont. The current length is 161.3 miles (259.6 km).
U.S. Route 231 in Tennessee runs north–south for 121.15 miles (194.97 km), entirely in Middle Tennessee, that starts south of Fayetteville at the Alabama state line, and ends north of Westmoreland at the Kentucky state line. For the majority of its length, between the Alabama state line and Trousdale County, it is concurrent with unsigned State Route 10.
State Route 82 is a secondary state highway that runs through Moore and Bedford counties in south central Tennessee in the United States. The route runs from an intersection with SR 55 in Lynchburg north and east to SR 64 near Beech Grove.
State Route 142 is a 24.59 mile long east-west state highway in West Tennessee.
State Route 152 is a 36.88-mile-long (59.35 km) east-west state highway traversing the flat farmland of West Tennessee.
State Route 190 is a 55.3-mile-long (89.0 km) north–south state highway that traverses the farmland of West Tennessee. It connects Trezevant and South Fulton via Pillowville, Gleason, Palmersville, and Latham.
State Route 194 is a 23.5-mile-long (37.8 km) north–south state highway in Fayette County, Tennessee, connecting Rossville with Braden via Macon and Oakland.
State Route 224 is a 26.6 miles (42.8 km) north-south state highway that is located almost entirely in McNairy County, Tennessee, connecting Michie with Enville via Stantonville and Adamsville.
State Route 227 is a 32.3-mile-long (52.0 km) east–west state highway in extreme southern Middle Tennessee. It is the only state highway in Tennessee that both begins and ends at the Alabama state line, with one end at Cypress Inn and the other just across the state line from Lexington, Alabama.
State Route 241 is a 12.0-mile-long (19.3 km) north–south state highway that lies mostly in northwestern Lawrence County, Tennessee, with a small portion extending into southern Lewis County.
State Route 242 is a 36.7 miles (59.1 km) north-south state highway that lies mostly in Lawrence County, Tennessee, United States. It connects Iron City with Henryville via Westpoint and Lawrenceburg.
State Route 273 is a 36.9-mile-long (59.4 km) east–west state highway traversing the hills of southern Middle Tennessee.
State Route 287 is a 40.5-mile-long (65.2 km) north-south state highway located entirely in Warren County in Middle Tennessee. It connects Viola with Rock Island via Morrison, Centertown, Midway, and Rock Island State Park. SR 287's routing is somewhat unique in that it forms a nearly C-shaped arch around the southern, western, and northern sides of McMinnville.
US 64 near Deerfield 
US 43 in Summertown 
