U.S. Route 79 is a United States highway in the Southern United States. The route is officially considered and labeled as a north–south highway, but its path is actually more of a diagonal northeast–southwest highway. The highway's northern/eastern terminus is in Russellville, Kentucky, at an intersection with U.S. Route 68 and KY 80. Its southern/western terminus is in Round Rock, Texas, at an interchange with Interstate 35, ten miles (16 km) north of Austin. US 79, US 68, and Interstate 24/US 62 are the primary east–west access points for the Land Between the Lakes recreation area straddling the Kentucky/Tennessee border.
U.S. Route 43 (US 43) is a 410-mile-long (660 km) north–south United States Highway in the Southern states of Alabama and Tennessee. It travels from Prichard, Alabama, to Columbia, Tennessee. The highway's southern terminus is in Prichard, at an intersection with US 90, and its northern terminus is in Columbia at an intersection with US 31/US 412/US 412 Bus.
U.S. Route 411 (US 411) is an alternate parallel-highway associated with US 11. It extends for about 309.7 miles (498.4 km) from US 78 in Leeds, Alabama, to US 25W/US 70 in Newport, Tennessee. US 411 travels through northeastern Alabama, northwestern Georgia, and southeastern Tennessee. It is signed north-south, as with most highways that have odd numbers, but the route runs primarily in a northeast-southwest direction, and covers a more east-west mileage than it does north-south. Notable towns and cities along its route include Gadsden, Alabama; Rome, Georgia; Cartersville, Georgia; Maryville, Tennessee; Sevierville, Tennessee, and Newport, Tennessee.
U.S. Route 51 (US 51), mostly overlapped by the unsigned State Route 3 (SR 3), is a north–south state highway in the U.S. state of Tennessee, that is 135.9 miles (218.71 km) long, completely within West Tennessee. It begins in Shelby County and ends in Obion County. The SR 3 designation is seen largely on mileposts.
Mississippi Highway 16 is a state highway in central Mississippi. It runs east–west for 186.4 miles (300.0 km), from the Mississippi Delta region to the Alabama state line. MS 16 serves 8 counties: Issaquena, Sharkey, Yazoo, Humphreys, Madison, Leake, Neshoba, and Kemper.
State Route 14 is a south–north route from the Mississippi border in Memphis, Tennessee to an intersection with State Route 54 in Tipton County.
State Route 15 is a west–east route from Memphis to Monteagle. For much of its route it has an unsigned concurrency with U.S. Route 64. SR 15 does travel through the southern part of all three Grand Divisions of the state: West Tennessee, Middle Tennessee, and East Tennessee.
State Route 76 (SR 76) is a state highway in Tennessee, traversing the state in a northeast-southwest axis from east of Memphis to north of Nashville. SR 76 is unique in that it actually changes its cardinal directions in Clarksville at the junction with US 41A and US 41A Bypass.
U.S. Route 127 in Tennessee is a 129.5-mile-long (208.4 km) United States Numbered Highway from Chattanooga to the Kentucky state line at Static. The highways connects through Dunlap, Pikeville, Crossville, and Jamestown. Throughout its length, US 127 straddles the line between East Tennessee and Middle Tennessee.
U.S. Route 31A is a 76.94-mile-long (123.82 km) alternate route of U.S. Route 31 that exists between Nashville and Pulaski, Tennessee. It is located entirely in Middle Tennessee and except for the Lewisburg bypass, where it is concurrent with SR 106, it is entirely concurrent with unsigned State Route 11.
U.S. Route 421 is a north–south United States highway that runs for 43.4 miles (69.8 km) in East Tennessee, connecting the cities of Mountain City and Bristol.
State Route 186 is a state highway in the U.S. state of Tennessee. It runs from Trenton southward to Jackson, passing through the towns of Gibson and Three Way along the way. The southern portion serves as a western bypass for the city of Jackson, which is signed as U.S. Route 45 Bypass.
State Route 50 (SR 50) is a west–to–east highway in Middle Tennessee. The road begins near Only and ends in Altamont. The current length is 161.3 miles (259.6 km).
State Route 35 is a north–south state highway in East Tennessee. The 81.35 miles (130.92 km) long state highway traverses Blount, Sevier, a small portion of Jefferson, Cocke, and Greene Counties. Most of the route is a secret, or hidden designation, as it runs concurrently with U.S. Highways in the area.
State Route 130 is a 51.3-mile-long (82.6 km) east–west state highway in Middle Tennessee.
State Route 179 is a 43.4-mile-long (69.8 km) east–west state highway in West Tennessee, connecting Covington with Whiteville via Stanton and Dancyville.
State Route 194 is a 23.5-mile-long (37.8 km) north–south state highway in Fayette County, Tennessee, connecting Rossville with Braden via Macon and Oakland.
State Route 222 is a 12.9 miles (20.8 km) long north-south state highway in southern West Tennessee. It connects the towns of Somerville and Stanton with Interstate 40.
State Route 273 is a 36.9-mile-long (59.4 km) east–west state highway traversing the hills of southern Middle Tennessee.
State Route 384 is a 11.3-mile-long (18.2 km) north-south state highway in Tipton County, Tennessee.
SR 76 north of Somerville 
