Interstate 40 (I-40) is a major east–west transcontinental Interstate Highway in the southeastern and southwestern portions of the United States. At a length of 2,556.61 miles (4,114.46 km), it is the third-longest Interstate Highway in the country, after I-90 and I-80. From west to east, it passes through California, Arizona, New Mexico, Texas, Oklahoma, Arkansas, Tennessee, and North Carolina. Its western terminus is at I-15 in Barstow, California, while its eastern terminus is at a concurrency with U.S. Route 117 (US 117) and North Carolina Highway 132 (NC 132) in Wilmington, North Carolina. Major cities served by the interstate include Flagstaff, Arizona; Albuquerque, New Mexico; Amarillo, Texas; Oklahoma City, Oklahoma; Little Rock, Arkansas; Memphis, Nashville, and Knoxville in Tennessee; and Asheville, Winston-Salem, Greensboro, Durham, Raleigh, and Wilmington in North Carolina.
U.S. Route 79 is a United States highway in the Southern United States. The route is officially considered and labeled as a north–south highway, but its path is actually more of a diagonal northeast–southwest highway. The highway's northern/eastern terminus is in Russellville, Kentucky, at an intersection with U.S. Route 68 and KY 80. Its southern/western terminus is in Round Rock, Texas, at an interchange with Interstate 35, ten miles (16 km) north of Austin. US 79, US 68, and Interstate 24/US 62 are the primary east–west access points for the Land Between the Lakes recreation area straddling the Kentucky/Tennessee border.
U.S. Route 70 or U.S. Highway 70 is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central Arizona. It is a major east–west highway of the Southeastern, Southern and Southwestern United States. Established as one of the original highways of 1926, it originally ran only to Holbrook, Arizona, then was extended in 1934 as a coast to coast route, with the current eastern terminus near the Atlantic Ocean in Atlantic, North Carolina, and the former western terminus near the Pacific Ocean in Los Angeles, California. The current western terminus was then truncated to US 60 / SR 77 in Globe, Arizona. Before the completion of the Interstate system, U.S. Highway 70 was sometimes referred to as the "Broadway of America", due to its status as one of the main east–west thoroughfares in the nation. It was also promoted as the "Treasure Trail" by the U.S. Highway 70 Association as of 1951.
State Route 1, known as the Memphis to Bristol Highway, is a 538.8-mile-long (867.1 km) mostly-unsigned state highway in the U.S. state of Tennessee. It stretches from the Arkansas state line at Memphis in the southwest corner of the state to Bristol in the northeast part. Most of the route travels concurrently with U.S. Route 70 and US 11W. It is the longest highway of any kind in the state of Tennessee. The route is signed as both in the state of Tennessee, a Primary and Secondary Highway
U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.3 miles (1,357.2 km) from Cash, Arkansas to Charleston, South Carolina. From Byhalia, Mississippi to Birmingham, Alabama, US 78 runs concurrently with Interstate 22 (I-22). The highway’s western terminus is at US 67 /Arkansas Highway 226 (AR 226) near Cash and its eastern terminus is on Line Street, in Charleston. Prior to November 2023, before the western extension, the highway's former western terminus is at US 64/US 70/US 79 in Memphis, Tennessee.
State Route 374 is an east west state highway in Montgomery County, Tennessee, that acts as a cross-town arterial road for motorists in Clarksville. The route serves as a northern bypass around downtown Clarksville, and also provides access to Fort Campbell, a United States Army installation that is the headquarters for the 101st Airborne Division and the 160th Special Operations Aviation Regiment (Airborne). It currently runs from U.S. Route 79 to US 41 Alternate. The route is planned to be extended southward to SR 149 from its western terminus, replacing a short section of that route to SR 13.
State Route 14 is a south–north route from the Mississippi border in Memphis, Tennessee to an intersection with State Route 54 in Tipton County.
State Route 12 is a highway from Davidson County, Tennessee to Montgomery County, Tennessee.
U.S. Route 70 Alternate is a 61.7-mile-long (99.3 km) alternate route to US 70 between Brownsville, and Huntingdon in West Tennessee. Signage along this route, and on most maps, show it as US 70A and not US 70 Alternate.
State Route 13, in the United States, is a south–north route from the Alabama border in Wayne County to the Kentucky border in Montgomery County. The entire route is located in western Middle Tennessee.
State Route 76 (SR 76) is a state highway in Tennessee, traversing the state in a northeast-southwest axis from east of Memphis to north of Nashville. SR 76 is unique in that it actually changes its cardinal directions in Clarksville at the junction with US 41A and US 41A Bypass.
U.S. Route 70 enters the state of Tennessee from Arkansas via the Memphis & Arkansas Bridge in Memphis, and runs west to east across 21 counties in all three Grand Divisions of Tennessee, with a total length of 478.48 miles (770.04 km), to end at the North Carolina state line in eastern Cocke County. Along the route, US 70 is accompanied with various U.S. and state highways, including those in three of the state's four major cities.
In Tennessee, U.S. Route 64 stretches 404.1 miles (650.3 km) from the Mississippi River in Memphis to the North Carolina state line near Ducktown. The highway, along with US 72, is a major route for travel between Memphis and Chattanooga.
U.S. Route 431 in Tennessee totals an estimated 116 miles (187 km) through Lincoln, Marshall, Maury, Williamson, Davidson, and Robertson counties in Middle Tennessee.
Several special routes of U.S. Route 70 exist. In order from west to east, these special routes are as follows.
Several special routes of U.S. Route 41 exist, including three in Wisconsin. In order from south to north they are as follows.
State Route 48 (SR 48) is a long north–south state highway in Middle Tennessee. It traverses six counties, and it is 103.86 miles (167.15 km) long.
U.S. Route 31 (US 31) is a part of the United States Numbered Highway System that runs from Spanish Fort, Alabama, to Mackinaw City, Michigan. In the U.S. state of Tennessee, it runs concurrently with Interstate 65 (I-65) for the first mile northward from the Tennessee state line. There US 31 parallels I-65 to downtown Nashville. At Pulaski US 31 meets the southern terminus of US 31A in Tennessee. US 31 continues due north through Lynnville, Columbia, Spring Hill, Franklin and Brentwood to Nashville. The route splits into US 31E and US 31W in Nashville and go into Kentucky.
U.S. Route 41 Alternate, also signed U.S. Route 41A in Tennessee (US 41A), connects the town of Monteagle, Tennessee, with Hopkinsville, Kentucky, 10 miles (16 km) north of the Tennessee line. It serves the city of Clarksville, Tennessee, on its way to Nashville, where it briefly runs concurrently with US 41. It then separates again to serve Shelbyville, Winchester, and Tullahoma before rejoining the main route atop Monteagle Mountain. US 41A runs west of US 41 for its entire length, aside from one mile in downtown Nashville where they are concurrent. US 41A is also concurrent with U.S. Route 31A from Nashville to Triune, Tennessee, for a distance of approximately 25 miles (40 km).
State Route 77 (SR 77), is an east–west state highway in the U.S. state of Tennessee. The 84.86-mile-long (136.57 km) route traverses the flat farmland of West Tennessee.
I-55 / US 61 / US 64 / US 70 / US 78 / US 79 at the Arkansas state line/Mississippi River in Memphis 
US 79 at the Kentucky state line northeast of Clarksville 
