U.S. Route 79 is a United States highway in the Southern United States. The route is officially considered and labeled as a north–south highway, but its path is actually more of a diagonal northeast–southwest highway. The highway's northern/eastern terminus is in Crawfordsville, Kentucky, where it turns into Bing's Store Road just north of IH-40. Its southern/western terminus is in Round Rock, Texas, at an interchange with Interstate 35, ten miles (16 km) north of Austin. US 79, US 68, and Interstate 24/US 62 are the primary east–west access points for the Land Between the Lakes recreation area straddling the Kentucky/Tennessee border.
U.S. Route 31 or U.S. Highway 31 (US 31) is a major north–south U.S. highway connecting southern Alabama to northern Michigan. Its southern terminus is at an intersection with US 90/US 98 in Spanish Fort, Alabama. Its northern terminus is at an interchange with Interstate 75 (I-75) south of Mackinaw City, Michigan.
U.S. Route 43 (US 43) is a 410-mile-long (660 km) north–south United States Highway in the Southern states of Alabama and Tennessee. It travels from Prichard, Alabama, to Columbia, Tennessee. The highway's southern terminus is in Prichard, at an intersection with US 90, and its northern terminus is in Columbia at an intersection with US 31/US 412/US 412 Bus.
U.S. Route 411 (US 411) is an alternate parallel-highway associated with US 11. It extends for about 309.7 miles (498.4 km) from US 78 in Leeds, Alabama, to US 25W/US 70 in Newport, Tennessee. US 411 travels through northeastern Alabama, northwestern Georgia, and southeastern Tennessee. It is signed north-south, as with most highways that have odd numbers, but the route runs primarily in a northeast-southwest direction, and covers a more east-west mileage than it does north-south. Notable towns and cities along its route include Gadsden, Alabama; Rome, Georgia; Cartersville, Georgia; Maryville, Tennessee; Sevierville, Tennessee, and Newport, Tennessee.
U.S. Route 641 (US 641) is a U.S. Route in Tennessee and Kentucky. It runs for 165.45 miles (266.27 km) from US 64 south of Clifton, Tennessee to an intersection with US 60 in Marion, Kentucky. While it is considered a spur route of U.S. Route 41, the two routes no longer connect.
State Route 79 (SR 79) is a 117-mile-long (188 km) state highway that extends northeastward from Birmingham to the Tennessee state line. Prior to the completion of Interstate 65 (I-65), SR 79 was the southern part of the route that connected Birmingham and Huntsville.
State Route 22 is a 172.8-mile long (278.1 km) south-to-north state highway in the western part of Tennessee, United States. It begins at the Mississippi state line in McNairy County, where the roadway continues as Mississippi Highway 2. It ends at the Kentucky state line in Lake County, when it crosses into the Kentucky Bend, a detached portion of Fulton County, Kentucky. The monument for the 1862 Battle of Island Number Ten in the American Civil War is located on SR 22, about 3 mi (4.8 km) north of Tiptonville.
State Route 100 is a west–east state highway in both West Tennessee and Middle Tennessee that connects Whiteville with Nashville. It is 158.31 mi (254.8 km) long.
State Route 15 is a west–east route from Memphis to Monteagle. For much of its route it has an unsigned concurrency with U.S. Route 64. SR 15 does travel through the southern part of all three Grand Divisions of the state: West Tennessee, Middle Tennessee, and East Tennessee.
State Route 76 (SR 76) is a state highway in Tennessee, traversing the state in a northeast-southwest axis from east of Memphis to north of Nashville. SR 76 is unique in that it actually changes its cardinal directions in Clarksville at the junction with US 41A and US 41A Bypass.
State Road 69 is a road running through Calhoun and Jackson counties in northwest Florida. The road is almost entirely two-lanes wide.
State Route 21 (SR 21) is a two lane highway that runs from the Mississippi River west of Tiptonville, Tennessee to the Kentucky state line north of Union City. This road provides access to Reelfoot Lake State Park.
State Route 54 is a west–east rural highway in West Tennessee, which runs from Covington to just north of Paris.
State Route 16 is a state highway in the U.S. state of Tennessee. Its southern terminus is at the Alabama state line, where it continues as State Route 79 in Alabama. From there, it continues to Winchester, where it becomes unsigned in a concurrency with U.S. Route 41A. This concurrency lasts until its northern terminus in Williamson County, at a junction with U.S. Route 31A.
State Route 218 is a state highway and bypass around the city of Paris, in the western portion of the U.S. state of Tennessee.
State Route 69A is a 27.1-mile-long (43.6 km) state highway and alternate route of SR 69 in the western portion of the U.S. state of Tennessee. It travels through a mostly rural area of western Tennessee. It is one of three remaining alternate state routes in Tennessee.
State Route 128 (SR 128) is a state highway in western and western Middle Tennessee.
State Route 192 is a secondary state highway that runs through Benton County in western Tennessee in the United States. The route serves as a loop to the west of U.S. Route 641 in the southern part of the county, serving the community of Holladay. SR 192 is a two-lane undivided road its entire length, passing through rural areas.
State Route 114 is a north–south state highway that traverses six counties in the western grand division of Tennessee. The 96.49-mile-long (155.29 km) route travels from Clifton Junction to an area south of Paris via Scotts Hill, Lexington, and the Natchez Trace State Park.
State Route 202 is a 20.5-mile-long (33.0 km) north–south state highway in Decatur County, Tennessee, connecting Saltillo with Beacon via Decaturville.
SR 20 at the Alabama state line near Florence, AL 
KY 97 at the Kentucky state line near Puryear 
