U.S. Route 411 (US 411) is an alternate parallel-highway associated with US 11. It extends for about 309.7 miles (498.4 km) from US 78 in Leeds, Alabama, to US 25W/US 70 in Newport, Tennessee. US 411 travels through northeastern Alabama, northwestern Georgia, and southeastern Tennessee. It is signed north-south, as with most highways that have odd numbers, but the route runs primarily in a northeast-southwest direction, and covers a more east-west mileage than it does north-south. Notable towns and cities along its route include Gadsden, Alabama; Rome, Georgia; Cartersville, Georgia; Maryville, Tennessee; Sevierville, Tennessee, and Newport, Tennessee.
State Route 56 is a 160.6-mile-long (258.5 km) state highway that runs south to north in Middle Tennessee, from the Alabama state line near Sherwood to the Kentucky state line near Red Boiling Springs.
U.S. Route 25W (US 25W) is the western branch of US 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin.
State Route 22 is a 172.8-mile long (278.1 km) south-to-north state highway in the western part of Tennessee, United States. It begins at the Mississippi state line in McNairy County, where the roadway continues as Mississippi Highway 2. It ends at the Kentucky state line in Lake County, when it crosses into the Kentucky Bend, a detached portion of Fulton County, Kentucky. The monument for the 1862 Battle of Island Number Ten in the American Civil War is located on SR 22, about 3 mi (4.8 km) north of Tiptonville.
State Route 52 is an east–west state highway that crosses eight counties in northern and northeastern Tennessee. The 141.4-mile-long (227.6 km) route originates in Orlinda along SR 49 and ends in Elgin along U.S. Route 27.
State Route 12 is a highway from Davidson County, Tennessee to Montgomery County, Tennessee.
State Route 96 is an east–west and north–south highway in Middle Tennessee. The road begins in Dickson and ends in Granville. The current length is 126.7 mi (203.9 km). Along its path it goes through 10 counties. Locals mostly refer to it as Highway 96.
State Route 10 is a south–north route from the Alabama state line in Lincoln County to the Kentucky state line in Macon County.
State Route 13, in the United States, is a south–north route from the Alabama border in Wayne County to the Kentucky border in Montgomery County. The entire route is located in western Middle Tennessee.
State Route 76 (SR 76) is a state highway in Tennessee, traversing the state in a northeast-southwest axis from east of Memphis to north of Nashville. SR 76 is unique in that it actually changes its cardinal directions in Clarksville at the junction with US 41A and US 41A Bypass.
State Route 70 is a state-maintained highway in East Tennessee, beginning at the border with North Carolina in the midst of the Cherokee National Forest and the Great Smoky Mountains and ending at the Virginia border in the extremely rural and mountainous terrain of Hancock County.
U.S. Route 127 in Tennessee is a 129.5-mile-long (208.4 km) United States Numbered Highway from Chattanooga to the Kentucky state line at Static. The highways connects through Dunlap, Pikeville, Crossville, and Jamestown. Throughout its length, US 127 straddles the line between East Tennessee and Middle Tennessee.
State Route 25 is a 67.6-mile-long (108.8 km) east–west state highway in northern Middle Tennessee.
State Route 32 is a state highway in East Tennessee. For most of its route, it is an unsigned companion route concurrent with U.S. Route 25E. The highway stretches 89 miles from the North Carolina state line to the Tennessee-Kentucky state line near the town of Cumberland Gap.
State Route 50 (SR 50) is a west–to–east highway in Middle Tennessee. The road begins near Only and ends in Altamont. The current length is 161.3 miles (259.6 km).
State Route 53 (SR 53) is a north–south state highway that traverses six counties in Middle Tennessee. It is 113.5 miles (182.7 km) long.
U.S. Route 231 in Tennessee runs north–south for 121.15 miles (194.97 km), entirely in Middle Tennessee, that starts south of Fayetteville at the Alabama state line, and ends north of Westmoreland at the Kentucky state line. For the majority of its length, between the Alabama state line and Trousdale County, it is concurrent with unsigned State Route 10.
State Route 28 is a state highway in the state of Tennessee, traversing the state in a north–south axis from south of Jasper to the Kentucky state line at Static.
U.S. Route 41 Alternate, also signed U.S. Route 41A in Tennessee (US 41A), connects the town of Monteagle, Tennessee, with Hopkinsville, Kentucky, 10 miles (16 km) north of the Tennessee line. It serves the city of Clarksville, Tennessee, on its way to Nashville, where it briefly runs concurrently with US 41. It then separates again to serve Shelbyville, Winchester, and Tullahoma before rejoining the main route atop Monteagle Mountain. US 41A runs west of US 41 for its entire length, aside from one mile in downtown Nashville where they are concurrent. US 41A is also concurrent with U.S. Route 31A from Nashville to Triune, Tennessee, for a distance of approximately 25 miles (40 km).
State Route 235 is a 27.3-mile-long (43.9 km) north–south state highway in Middle Tennessee. It connects Dickson to Cunningham via Sylvia, Vanleer, and Slayden.
US 79 in Dover 
KY 383 at Kentucky state line near Orlinda
