State Route 56 is a 160.6-mile-long (258.5 km) state highway that runs south to north in Middle Tennessee, from the Alabama state line near Sherwood to the Kentucky state line near Red Boiling Springs.
State Route 24 is an unsigned west–east state highway in Tennessee, as it coincides with U.S. Route 70 and U.S. Route 70N for its entire duration from Nashville to Crossville. The road begins in western Nashville and ends in Crossville. It runs alongside Interstate 40 for its entire length.
State Route 1, known as the Memphis to Bristol Highway, is a 538.8-mile-long (867.1 km) mostly-unsigned state highway in the U.S. state of Tennessee. It stretches all the way from the Arkansas state line at Memphis in the southwest corner of the state to Bristol in the northeast part. Most of the route travels concurrently with U.S. Route 70 and US 11W. It is the longest highway of any kind in the state of Tennessee. The route is signed as both in the state of Tennessee, a Primary and Secondary Highway
U.S. Route 11E (US 11E) is a divided highway of US 11 in the U.S. states of Tennessee and Virginia. The United States Numbered Highway, which is complemented by US 11W to the north and west, runs 120.94 miles (194.63 km) from US 11, US 11W, and US 70 in Knoxville, Tennessee, north and east to US 11, US 11W, US 19, and US 421 in Bristol, Virginia. US 11E connects Knoxville and the twin cities of Bristol, Virginia, and Bristol, Tennessee, with the East Tennessee communities of Morristown, Greeneville, and Johnson City. The U.S. Highway runs concurrently with US 70 and US 25W east of Knoxville, US 321 from Greeneville and Johnson City, and both US 19W and US 19 between Johnson City and Bristol. US 11E also has an unsigned concurrency with State Route 34 (SR 34) for almost all of its course in Tennessee.
State Route 22 is a 172.8-mile long (278.1 km) south-to-north state highway in the western part of Tennessee, United States. It begins at the Mississippi state line in McNairy County, where the roadway continues as Mississippi Highway 2. It ends at the Kentucky state line in Lake County, when it crosses into the Kentucky Bend, a detached portion of Fulton County, Kentucky. The monument for the 1862 Battle of Island Number Ten in the American Civil War is located on SR 22, about 3 mi (4.8 km) north of Tiptonville.
State Route 44 is a state highway in the U.S. state of Tennessee. It runs from US 11E/US 19W/SR 34 in Bluff City, just south of the split of US 19W and US 19E, northeast via Hickory Tree and Holston Valley to the Virginia state line, where it becomes Virginia State Route 75. The entire highway is located within Sullivan County.
State Route 96 is an east–west and north–south highway in Middle Tennessee. The road begins in Dickson and ends in Granville. The current length is 126.7 mi (203.9 km). Along its path it goes through 10 counties. Locals mostly refer to it as Highway 96.
State Route 20 (SR 20) is a 143.04-mile (230.20 km) long east–west primary state highway that begins in Dyersburg and ending near Summertown. SR 20 is unsigned and concurrent with U.S. Route 412 (US 412) for its entire length, except for a short section between Hohenwald and Summertown. Along its route, SR 20 traverses parts of both Middle Tennessee and West Tennessee.
U.S. Route 27 in Tennessee runs from the Georgia state line in Chattanooga to the Kentucky state line in Isham. It forms the informal border between the Eastern and Central Time Zones of the state. However, it stays in the Eastern Time Zone.
U.S. Route 70 enters the state of Tennessee from Arkansas via the Memphis & Arkansas Bridge in Memphis, and runs west to east across 21 counties in all three Grand Divisions of Tennessee, with a total length of 478.48 miles (770.04 km), to end at the North Carolina state line in eastern Cocke County. Along the route, US 70 is accompanied with various U.S. and state highways, including those in three of the state's four major cities.
State Route 59 is a state highway in Tennessee. It runs from the Mississippi River to just north of Somerville passing through Tipton and Fayette counties. Excluding the portion where it is concurrent with US 51 in Covington, which is 4-lane highway, it is a two-lane rural highway throughout its length and carries a 55 miles per hour (89 km/h) speed limit except when it passes through towns, in which case this speed limit can be significantly less.
State Route 26 is an east–west highway in Middle Tennessee. The road begins in Lebanon and ends in Sparta. The current length is 59.25 mi (95.4 km).
State Route 49 is a state highway in Tennessee. The route forms a broad southern arc that passes through the rural Middle Tennessee towns of Dover, Erin, Charlotte, Ashland City, Pleasant View, and Springfield.
State Route 32 is a state highway in East Tennessee. For most of its route, it is an unsigned companion route concurrent with U.S. Route 25E. The highway stretches 89 miles from the North Carolina state line to the Tennessee-Kentucky state line near the town of Cumberland Gap.
State Route 198 is a relatively short, secondary north–south state highway located in West Tennessee. Although this road runs in a generally east to west direction, The Tennessee Department of Transportation has designated this as a north to south highway.
State Route 48 (SR 48) is a long north–south state highway in Middle Tennessee. It traverses six counties, and it is 103.86 miles (167.15 km) long.
State Route 46 is a north–south state highway located in Middle Tennessee. It mainly goes on a northwest to southeast course while passing through towns and cities such as Cumberland City, Dickson, Leipers Fork, along with mainly rural areas of Stewart, Houston, Dickson, Hickman and Williamson Counties.
State Route 74 (SR 74) is a north–south state highway located primarily in Bradley County, Tennessee. It runs from the Georgia state line to downtown Cleveland. The route serves as a major shortcut, along with SR 60, for Cleveland citizens to commute to Atlanta, Georgia.
State Route 235 is a 27.3-mile-long (43.9 km) north–south state highway in Middle Tennessee. It connects Dickson to Cunningham via Sylvia, Vanleer, and Slayden.
SR 48 at Dickson 
US 70 at White Bluff 
SR 48 at Charlotte 
